Andrographolide and 14-deoxy-11,12-didehydroandrographolide from Andrographis paniculata attenuate high glucose-induced fibrosis and apoptosis in murine renal mesangeal cell lines

A bitter plant with a sweet future? A comprehensive review of an oriental medicinal plant: Andrographis paniculata

“…ether, MeOH, CHCl 3 and water Preclinical pharmacology: Anti-malarial (Dua et al 2004) References: Dua et al (2004) Vinayak 2008), antidiabetic (Lee et al 2010a), antiatherosclerotic (Chen et al 2004), cholestatic (Lee et al 2010a), respiratory conditions (Roxas and Jurenka 2007), analgesic, antipyretic and antiulcerogenic (Madav et al 1995) studies. The screening techniques used in the previous decades were primal and involved simple methodologies.…”

Edible plants from traditional Chinese medicine is a promising alternative for the management of diabetic nephropathy

“…For in vitro studies, there are many DN models commonly used in TCM edible plants, such as mouse embryonic fibroblastadipose like cells (3T3-L1), L6 myotubes, human mesangial cells, mouse mesangial cells (MES-13), mouse podocyte cells, murine skeletal myoblasts (C2C12), murine hepatocytes (H4IIE), renal proximal tubular epithelial cells (HK-2), rat insulinoma cells (INS-1), glomerular endothelial cells, and vascular endothelial cells (Eid et al, 2010;Lee et al, 2010;Li et al, 2009Li et al, , 2010 Yu, Gao, & Liu, 2010;Zhang, Liu, Xiong, Gong, & Tan, 2012). All these in vivo and in vitro models enhance our understanding of the mechanisms of the protective effects of TCM edible plants against DN.…”

Andrographolide a New Potential Drug for the Long Term Treatment of Rheumatoid Arthritis Disease

“…The most important among them, characterized by Balmain and Connolly in 1973, are: 14-deoxy-11,12-didehydroandrographolide, withan average content in the leaf of 0.1%, 14-deoxyandrographolide (0.02%), 14-deoxy-11-oxoandrographolide (0.12%) (Figure 2) [3]. In other hand has been described that 14-deoxy-11,12-didehydroandrographolide possess vasorelaxant and antihypertensive [30,31], anti-herpes [7], antioxidant and hepatoprotective [32], antithrombotic [33], antiretroviral [6], and antidiabetic properties [34]. Meanwhile 14-deoxyandrographolide exert hepatoprotective [35], uterine smooth muscle relaxant [36], immunomodulator [37], platelet activating factor antagonist [38], and vasorelaxant and antihypertensive [39] effects.…”