Andrographis paniculata-mediated synthesis of silver nanoparticles: antimicrobial properties and computational studies

Abstract

The present work reports a simple-economical procedure for the formation of silver nanoparticles by using controlled addition of concentration of cetyltrimethylammonium bromide (CTAB) as a capping agent, taking one-factor-at-a-time into consideration during the optimization process. Wet chemical method for silver(I) reduction has been used to synthesize nanoparticles using Andrographis paniculata. During the reaction, antioxidant property of biosystem reduces silver(I) to metallic silver(0) and CTAB encapsulates preventing the agglomeration, acting as barrier for the growth of the particle. The synthesised nanoparticle was characterised by powder X-ray diffraction, Fourier-transform spectroscopy, UV-Vis spectroscopy and SEM. The results showed that the silver nanoparticles doped with CTAB and its high crystallinity can be obtained using simple solvent method. The size of the nanoparticle by XRD, UV-Vis and SEM were found to be 0.897 nm, 45 nm and 18 to 43 nm, respectively. Tauc's plot of optical band gap suggested the movement of size towards quantum confinement for the synthesised nanoparticles was 2.25 eV. An antioxidant activity of A. paniculata and synthesized AgNps was studied by series of antioxidant assays. The nanoparticles were having antibacterial and antifungal activities when it was studied using Streptomycin and Ketoconazole as controls.

Biogenesis of Silver Nanoparticles and Its Multifunctional Anti-Corrosion and Anticancer Studies

“…Recently, nanoscience and technology have developed rapidly all over the world, largely by adopting the quality, advancement, and efficiency of nanoparticles [1,2]. The transition of metal nano-materials grabbed the attention of researchers due to massive applications in the field of environmental sciences, biomedical sciences, and electrochemical sciences [2][3][4][5][6][7][8]. The physical and chemical methods of synthesis of nanoparticles have limited advantages due to high toxicity [9][10][11].…”

Highly Selective Colorimetric Sensor of Mercury(II) Ions by Andrographolide-Stabilized Silver Nanoparticles in Water and Antibacterial Evaluation

“…The results indicate that andro-AgNPs exhibit excellent antibacterial activity, as demonstrated by their low MIC and MBC values in the nM range. This is consistent with previous studies that evaluated the antimicrobial activity of AgNPs synthesized using Andrographis paniculata extract. , Those studies showed that the AgNPs were effective against a variety of bacteria, including S. aureus, E.…”

Fabrication of anti-bacterial cotton bandage using biologically synthesized nanoparticles for medical applications

“…Rajakumar et al synthesized zinc oxide nanoparticles by exploiting the reducing and capping potential of A. paniculata leaf extract (Rajakumar et al 2018 ). Anantharaman et al used leaf extract of A. paniculata for the synthesis of AgNPs and evaluated its anti-microbial properties (Anantharaman et al 2020 ). Biological synthesis of titanium dioxide nanoparticles was carried out with leaves extract of A. paniculata by Rajeshkumar et al ( 2021 ).…”