Andrographis paniculata extract attenuates pathological cardiac hypertrophy and apoptosis in high-fat diet fed mice

Hsieh, You Liang; Shibu, Marthandam Asokan; Lii, Chong‐Kuei; Viswanadha, Vijaya Padma; Yao, Lin; Lai, Chao Hung; Chen, Yu Feng; Lin, Kuan Ho; Kuo, Wei Wen; Huang, Chih Yang

doi:10.1016/j.jep.2016.07.018

Cited by 38 publications

(32 citation statements)

References 51 publications

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“…However, anthocyanin treatment proved to be highly effective in regulating the effects of diabetics on cardiac health as seen from the reduced apoptosis levels and the down‐regulation in the expression of pro‐apoptotic proteins. Suppression of caspase activation and reduction of cytochrome c has been evidently correlated as a crucial event in the suppression of cardiac apoptosis associated with cardiac damages induced by DM, obesity and as well as drug overdose . Our present results also correlate with our previous reports on the cardio‐protective effects of other agents such as probiotics, co‐enzyme Q10, deep sea minerals, diallyl trisulfide and extracts of Alpinate oxyphyllae MIQ and Andrographis paniculata …”

Section: Discussionsupporting

confidence: 90%

“…The anti‐apoptotic proteins Bcl‐2, p‐BAD and Bcl‐xL were significantly decreased in STZ‐induced DM hearts but the levels remained comparatively high in the anthocyanin treatment group. Enhancement of IGFI‐R associated survival factors has been viewed as a hallmark for the effect of efficient cardioprotective agents and has been also observed in our previous studies . The enhancement of IGF‐I and its associated proteins including p‐PI3k, p‐Akt, Bcl‐2 and Bcl‐xL in the STZ‐induced DM rat hearts, could be possibly the result of a compensative survival mechanism activated to counter the elevated cardiac apoptosis .…”

Section: Discussionsupporting

confidence: 73%

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Cellular apoptosis and cardiac dysfunction in STZ‐induced diabetic rats attenuated by anthocyanins via activation of IGFI‐R/PI3K/Akt survival signaling

Huang

Wang

Fan

et al. 2017

Environmental Toxicology

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Anthocyanins are known cyto-protective agents against various stress conditions. In this study cardio-protective effect of anthocyanins from black rice against diabetic mellitus (DM) was evaluated using a streptozotocin (STZ)-induced DM rat model. Five-week-old male Wistar rats were administered with STZ (55 mg kg , IP) to induce DM; rats in the treatment group received 250 mg oral anthocyanin/kg/day during the 4-week treatment period. DM and the control rats received normal saline through oral gavage. The results reveal that STZ-induced DM elevates myocardial apoptosis and associated proapoptotic proteins but down-regulates the proteins of IGF1R mediated survival signaling mechanism. Furthermore, the functional parameters such as the ejection-fraction and fraction-shortening in the DM rat hearts declined considerably. However, the rats treated with anthocyanins significantly reduced apoptosis and the associated proapoptotic proteins and further increased the survival signals to restore the cardiac functions in DM rats. Anthocyanin supplementation enhances cardiomyocyte survival and restores cardiac function.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 73%

Cellular apoptosis and cardiac dysfunction in STZ‐induced diabetic rats attenuated by anthocyanins via activation of IGFI‐R/PI3K/Akt survival signaling

Huang

Wang

Fan

et al. 2017

Environmental Toxicology

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“…This shows that at low dose the A. paniculata extract triggers the translocation of NF-kb to produce IL-6. This finding of course is contrary to previous research that A. paniculata can block the activation of NF-kb, which is caused by difference in dose [23,24]. Even previous study have proved that A. paniculata triggers down-regulation of NF-kb.…”

Section: Discussioncontrasting

confidence: 89%

Andrographis paniculata can modulate the ratio of Treg to Th17 cells in atherosclerotic rats

Hendrata

Handono

Kalim

et al. 2018

Clinical Nutrition Experimental

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s u m m a r yThe purpose of this study is to analyze the effect of Andrographis paniculata (Burm F) in the modulation of naive T cell differentiation and its related cytokines in the rat model of atherosclerosis. Twenty-five male rats were assigned to five study groups, consisting of the control group (normal diet), the atherosclerosis rat group (atherogenic diet), and the atherosclerotic rat group receiving A. paniculata (Burm F) extracts in three doses, there were 0.6 mg/kgBBW (Ather þ AP1 group), 1.2 mg/kgBBW (Ather þ AP2 group) and 2.4 mg/kgBBW (Ather þ AP3 group). The numbers of Th17 and Treg cells were measured using flow cytometry. The IL-17 and IL-6 levels were analyzed using enzyme-linked immunosorbent assay technique. Th17 cell level increased significantly in the atherosclerosis group compared to the control group (p > 0.05). The A. paniculata extract in the 0.6 mg/kgBBW and 2.4 mg/kgBBW doses could decrease the Th17 cell count significantly compared to the atherosclerosis group (p < 0.05), despite did not achieve a normal value similar to the control group (p < 0.05). The A. paniculata extract in the 1.2 mg/kgBBW dose significantly increased Treg cell count compared to the other groups (p < 0.05). The ratio of Treg cells to Th17 cells dropped significantly in the atherosclerosis group to the control group (p > 0.05). A. paniculata extract of

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“…In addition, mitochondrial‐dependent intrinsic cardiac apoptosis is also observed in obese condition . Interruption of apoptosis is understood to be one of the possible strategies to reverse or attenuate cardiac disorders and in this regard, several alternative approaches are considered for their anti‐apoptotic benefits against obesity, DM and other pathological conditions . Andrographis paniculata (Burm.…”

Section: Introductionmentioning

confidence: 99%

Andrographolide mitigates cardiac apoptosis to provide cardio‐protection in high‐fat‐diet‐induced obese mice

Lin

Shibu

Kuo

et al. 2020

Environmental Toxicology

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Excessive intake of high fat diet (HFD) and associated obese conditions are critical contributors of cardiac diseases. In this study, an active metabolite andrographolide from Andrographis paniculata was found to ameliorate HFD-induced cardiac apoptosis. C57/BL6 mouse were grouped as control (n = 9), obese (n = 8), low dose (25 mg/kg/d) andrographolide treatment (n = 9), and high dose (50 mg/kg/d) andrographolide treatment (n = 9). The control group was provided with standard laboratory chow and the other groups were fed with HFD. Andrographolide was administered through oral gavage for 1 week. Histopathological analysis showed increase in apoptotic nuclei and considerable cardiac-damages in the obese group signifying cardiac remodeling effects. Further, Western blot results showed increase in pro-apoptotic proteins and decrease in the proteins of IGF-1R-survival signaling. However, feeding of andrographolide significantly reduced the cardiac effects of HFD. The results strongly suggest that andrographolide supplementation can be used for prevention and treatment of cardiovascular disease in obese patients.

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Andrographis paniculata extract attenuates pathological cardiac hypertrophy and apoptosis in high-fat diet fed mice

Cited by 38 publications

References 51 publications

Cellular apoptosis and cardiac dysfunction in STZ‐induced diabetic rats attenuated by anthocyanins via activation of IGFI‐R/PI3K/Akt survival signaling

Cellular apoptosis and cardiac dysfunction in STZ‐induced diabetic rats attenuated by anthocyanins via activation of IGFI‐R/PI3K/Akt survival signaling

Andrographis paniculata can modulate the ratio of Treg to Th17 cells in atherosclerotic rats

Andrographolide mitigates cardiac apoptosis to provide cardio‐protection in high‐fat‐diet‐induced obese mice

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