Andrographis paniculata absorbed ZnO nanofibers as a potential antimicrobial agent for biomedical applications

Abstract

The present study focuses on developing antimicrobial nanofibers with superhydrophobicity and insect repellent properties for wound dressing and biomedical applications. For the first time, Andrographis paniculata leaf extract was prepared and incorporated into ZnO nanofibers (AP-ZnO). The antifungal and antibacterial activities of AP-ZnO were tested using the agar plate method. Amid the bacteria and fungus strain tested, the prepared sample exhibited a greater efficiency against Staphylococcus aureus and Trichophyton rubrum respectively. AP-ZnO showed the highest larvicidal activity (100 ± 0.2) against Aedes aegypti, proving its insect repellent characteristics. The in vivo toxicity studies of AP-ZnO (100 μg ml−1) tested on Danio rerio ensure the biocompatibility of the prepared sample with maximum toxicity of 21.1% after 72 h, which is lower than commercial Prallethrin. Moreover, AP-ZnO-chitosan coated cotton fabric showed higher durability with contact angle (θ ∼ 151°) and was suggested to be used for self-cleaning applications in the biomedical sector. The examined results confirmed that AP-ZnO possesses different medicinal characteristics suitable for biomedical and pharmaceutical applications.

Recent developments in phycosynthesis of zinc oxide nanoparticles for biomedicine and environmental applications

“…In 2021, Brindha et al demonstrated the ZnO nanofiber formation absorbed with Andrographis paniculata (AP-ZnO) to test its antimicrobial property. These AP-ZnO possessed larvicidal activity as well against Aedes aegypti [95]. Recent studies have also revealed that when ZnO NPs were capped with histidine, it possessed effective photoluminescence (PL emission) properties.…”

Emerging Materials, Wearables, and Diagnostic Advancements in Therapeutic Treatment of Brain Diseases

“…Several viruses have the potential to attack the central nervous system and adjacent tissues, even if this is somewhat unusual [ 114 , 115 , 116 , 117 ]. Herpes simplex, Epstein-Barr, varicella zoster, cytomegalovirus, and influenza viruses are a few examples of potential sources.…”

Poly(butylene adipate-co-terephthalate)/Polylactic Acid/Tetrapod-Zinc Oxide Whisker Composite Films with Antibacterial Properties

“…However, PLA and PBAT are not compatible, which could be addressed by introducing a compatibilizer or chain extender. The most widely used commercial chain extender is the Joncryl ADR family Polymers 2024, 16, 1039 2 of 18 of copolymers composed of styrene, glycidyl methacrylate, and butyl acrylate. The ADR chain extender is expected to enhance the properties of the blends in film blow molding and the elongation at break [11].…”

“…When filled with nanocrystal cellulose-silver nanohybrids (NCC-Ag), the PBAT/PLA/NCC-Ag composite blend also exhibits antibacterial properties which could be used as potential antibacterial packaging material [ 14 ]. ZnO-based nanocomposites of different morphologies (spherical, hexagonal, nanofibers, and core–shell) have been extensively reported in the literature for their enhanced photocatalytic (degradation of methylene blue dye) and antibacterial activity (against E. coli and S. aureus ) [ 15 , 16 , 17 ]. The tetra-needle-like or tetrapod ZnO (T-ZnO) whisker was discovered in the 1940s and the method of preparation of T-ZnO was first reported in 1990 [ 18 ].…”