Androgens in relationship to cardiovascular risk factors in the menopausal transition

Mesch, Viviana; Siseles, Néstor; Maidana, Patricia; Boero, Laura; Sayegh, Fabiana; Prada, Mariela; Royer, Monique; Schreier, Laura; Benencia, H; Berg, Gabriela

doi:10.1080/13697130802416640

Cited by 46 publications

(24 citation statements)

References 35 publications

(25 reference statements)

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“…Our studies also showed that, as the menopausal transition goes ahead, androgenic status increases in association with abdominal fat deposition [9]. It should be remarked that waist circumference is an interesting surrogate marker of abdominal obesity, and we observed that abdominal obesity, more than menopausal status, is the main determinant of the differences found in androgenic profile.…”

supporting

confidence: 78%

Metabolic syndrome and cardiovascular risk factors in the menopausal transition

Siseles¹,

Berg

2009

Gynecological Endocrinology

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supporting

confidence: 78%

Metabolic syndrome and cardiovascular risk factors in the menopausal transition

Siseles¹,

Berg

2009

Gynecological Endocrinology

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“…Studies have already shown that elevated androgens and low SHBG are related to metabolic variables associated with CVD risk (11)(12)(13). However, some studies have shown that upon controlling for VAT, the relationship between metabolic variables and SHBG and/or bioavailable testosterone is no longer found (14)(15)(16). Furthermore, others have postulated that it is the bioavailable testosterone that regulates VAT accumulation associated with CVD risk, and may even directly contribute to CVD risk (10,17).…”

Section: Introductionmentioning

confidence: 99%

Androgenic sex steroids contribute to metabolic risk beyond intra‐abdominal fat in overweight/obese black and white women

Perry

Wang

Goldberg

et al. 2013

Obesity

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Objective: To determine the independent contribution of androgenic sex hormones beyond visceral adipose tissue (VAT) on metabolic risk. Design and Methods: A cross-sectional evaluation of 66 (36 white and 30 black) premenopausal overweight/obese women using multiple regression analyses to determine the independent effects of sex hormone-binding globulin (SHBG), total testosterone (TT), and free testosterone using the free androgen index (FAI) on metabolic variables above VAT. Results: SHBG contributed to the variance in insulin (P ¼ 0.003), insulin resistance using HOMA-IR (P ¼ 0.006), and high-density lipoprotein cholesterol 2 (P ¼ 0.029). TT contributed to the variance in systolic and diastolic blood pressure (P < 0.001), total cholesterol (P ¼ 0.003), low-density lipoprotein cholesterol (P ¼ 0.003), and apolipoprotein B (P ¼ 0.004). FAI contributed to the variance in the greatest number of metabolic variables beyond VAT. There was also a significant race-FAI interaction for fasting glucose (P ¼ 0.013). A Pearson's correlation coefficient showed a significant relationship between FAI and glucose in white women (r ¼ 0.48, P ¼ 0.003) while showing no relationship in black women (r ¼ À0.01, P ¼ 0.941). Conclusions: Our study showed that androgenic sex steroids contributed significantly to the variance in metabolic variables associated with health risk. However, they do not provide sufficient information relevant to glucose status in black women.

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“…In a cross-sectional study, our group evaluated the relationship between androgens and cardiovascular risk factors in the menopausal transition [15]. We found an increment in the androgenic milieu that correlated with abdominal fat, insulin-resistance, and atherogenic lipoproteins.…”

Section: Androgens/testosteronementioning

confidence: 99%

“…Concerning estradiol levels in this period of life, they are frequently higher than those found in premenopausal women [13,14], but, indeed, estradiol concentrations in perimenopausal women show a high degree of variability [13]. In turn, changes in androgen levels during the menopausal transition are controversial, although it is generally accepted that testosterone levels do not change significantly in this period of life [15]. Given that alterations of the hormonal profile begin in the early 40s, in the menopausal transition, consequently, changes in risk factors for CVD (such as anthropometric characteristics) could also be observed in this period.…”

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Abdominal Obesity and Metabolic Alterations in the Menopausal Transition

Berg

Mesch

Siseles

2012

Curr Obstet Gynecol Rep

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The prevalence of overweight and obesity is strikingly increasing worldwide. Obesity is a major risk factor for non-insulin-dependent diabetes mellitus, cardiovascular diseases, and cancer, and is also associated with various psychosocial consequences. Menopausal transition is associated with unfavorable changes in body composition and abdominal fat deposition, which is accompanied by an increment of insulin resistance/hyperinsulinemia, a decrease in sex hormone-binding globulin levels and, consequently, an increase in free testosterone and greater androgenicity. Central body fat also correlates with deleterious changes in adipokines and inflammation markers like leptin, C-reactive protein, and adiponectin. In addition, the greater deposition of visceral fat in the menopausal transition contributes to the development of an atherogenic lipoprotein profile, which includes high triglyceride and low high-density lipoprotein (HDL) cholesterol concentrations, as well as an increment of small dense low-density lipoprotein (LDL) subfraction, intermediate density lipoproteins (IDL), apolipoprotein (apo) B/apo A-I ratio and lipoprotein(a).

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Androgens in relationship to cardiovascular risk factors in the menopausal transition

Cited by 46 publications

References 35 publications

Metabolic syndrome and cardiovascular risk factors in the menopausal transition

Metabolic syndrome and cardiovascular risk factors in the menopausal transition

Androgenic sex steroids contribute to metabolic risk beyond intra‐abdominal fat in overweight/obese black and white women

Abdominal Obesity and Metabolic Alterations in the Menopausal Transition

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