Androgens in post-menopausal patients with systemic sclerosis

Perković, Dijana; Kaliterna, Dušanka Martinović; Jurišić, Zrinka; Lalovac, Miloš; Radić, Mislav

doi:10.1093/rheumatology/keu432

Cited by 7 publications

(9 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a previous study, we reported that post-menopausal female dcSSc patients have significantly higher levels of serum estrogens compared to age-matched healthy volunteers [11]. A subsequent study measuring serum E2 and testosterone levels in post-menopausal SSc patients confirmed higher serum E2 levels in post-menopausal dcSSc patients but significantly lower serum testosterone levels compared to healthy volunteers [12]. However, serum E2 levels in dcSSc males of comparable age to post-menopausal women have not been evaluated.…”

Section: Introductionmentioning

confidence: 93%

Estradiol levels are elevated in older men with diffuse cutaneous SSc and are associated with decreased survival

et al. 2019

View full text Add to dashboard Cite

Background Systemic sclerosis (SSc) is a female-predominant disease, characterized by excessive extracellular matrix deposition (ECM) with dermal and internal organ fibrosis. Considering the sex-based disparity in disease incidence, estradiol (E2), an estrogen form with pro-fibrotic effects, may play a role in SSc. We reported that post-menopausal women with diffuse cutaneous (dc)SSc have higher serum E2 levels compared to similar aged, healthy controls. Since males with SSc tend to have more severe disease, we examined serum E2 in dcSSc males in relation to disease characteristics and survival. Methods We measured serum E2 in 83 dcSSc men > 50 years old from the University of Pittsburgh Scleroderma Center and similar aged healthy controls. Using statistical modeling, we examined the associations between serum E2, internal organ involvement, autoantibody profiles, and survival. Results Male dcSSc patients had significantly higher serum E2 levels compared to healthy males and similar aged dcSSc post-menopausal women. Male dcSSc patients with high serum E2 had significantly more heart involvement, a trend for higher skin thickness progression rate, and worse survival. Using Cox regression modeling, increased serum E2 levels in anti-Scl-70 antibody-positive dcSSc males were associated with an increased risk of death. Conclusions dcSSc males > 50 years old have higher levels of serum E2 compared to healthy controls and dcSSc post-menopausal women. Elevated serum E2 levels in dcSSc males are associated with heart involvement, trend to progression of dermal fibrosis, and, if anti-Scl-70 antibody positive, worse survival. Our study expands on previous work implicating E2 in dermal fibrosis in SSc and associates E2 levels with internal organ involvement and survival. These data suggest a role for estrogen imbalance in dcSSc.

show abstract

Section: Introductionmentioning

confidence: 93%

Estradiol levels are elevated in older men with diffuse cutaneous SSc and are associated with decreased survival

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Studies examining androgen levels have yielded conflicting results, but high levels of oestradiol in older men are reported to be associated with heart involvement, skin progression, and death (24). Androgens may also be important in SSc pathogenesis and one study has identified higher levels of androgens in post-menopausal female patients with SSc carrying anti-topoisomerase antibodies (25).…”

Section: Pathogenesis (Jp)mentioning

confidence: 99%

Gender-related differences in systemic sclerosis

Hughes

Pauling

Armstrong-James

et al. 2020

Autoimmunity Reviews

View full text Add to dashboard Cite

Systemic sclerosis (SSc) is a complex autoimmune connective tissue disease which is characterised by widespread tissue fibrosis of the skin and internal organs, widespread vasculopathic alterations and immune system abnormalities. The condition is more common in women, but has a more severe expression of disease and higher mortality in men. Although the aetiopathogenesis of SSc is not yet fully understood, there is emerging evidence of important differences between men and women with the disease. This review brings together the current evidence on sex differences in SSc including epidemiology, pathophysiology, clinical expression of disease, mortality, SSc in transgender individuals, and psychosocial aspects of disease.

show abstract

“…It was postulated that ACA is generally present in localized SSc and higher level of hormones suppress the autoimmune process in the skin and synthesis of ACA. Surprisingly, the same study has shown a positive correlation between Scl-70 antibodies and androgen levels 120 .…”

Section: Sclerodermamentioning

confidence: 84%

Menopause and Rheumatic Disease

Talsania

Scofield

2017

Rheumatic Disease Clinics of North America

View full text Add to dashboard Cite

Abstract/Synopsis Menopause occurs naturally in women at about age 50. There is a wealth of data concerning the relationship of menopause to systemic lupus erythematosus, rheumatoid arthritis and osteoarthritis, while there are limited data concerning other rheumatic diseases. Age at menopause may affect the risk and course of rheumatic diseases. Osteoporosis, an integral part of inflammatory rheumatic diseases, is made worse by menopause. Hormone replacement therapy has been studied and its effects are varied depending upon the disease and even different manifestations within the same disease. Cyclophosphamide can induce early menopause but there is underlying decreased ovarian reserve in rheumatic diseases.

show abstract

Androgens in post-menopausal patients with systemic sclerosis

Cited by 7 publications

References 7 publications

Estradiol levels are elevated in older men with diffuse cutaneous SSc and are associated with decreased survival

Estradiol levels are elevated in older men with diffuse cutaneous SSc and are associated with decreased survival

Gender-related differences in systemic sclerosis

Menopause and Rheumatic Disease

Contact Info

Product

Resources

About