Androgens in cardiac fibrosis and other cardiovascular mechanisms

Čulić, Viktor

doi:10.1016/j.ijcard.2014.11.079

Cited by 18 publications

(8 citation statements)

References 54 publications

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“…The present study also demonstrates that castration results in increased volumetric density of vascular collagen fibers, proportional to the duration of hypogonadism. Similar changes have been reported to occur in the penis [242539] and myocardium [4041] in studies involving androgen hormone deficiency. These results supported by the observation that androgen receptor knockout in mice exacerbates cardiac fibrosis [42].…”

Section: Discussionsupporting

confidence: 81%

Histomorphological changes in the common carotid artery of the male rat in induced hypogonadism

et al. 2018

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The role of androgens in the development of cardiovascular diseases remains controversial. The current study therefore sought to determine the changes in the histomorphology of the common carotid artery of the male rat in orchidectomy-induced hypogonadism. Twenty-two Rattus norvegicus male rats aged 2 months were used. The rats were randomly assigned into baseline (n=4), experimental (n=9), and control (n=9) groups. Hypogonadism was surgically induced in the experimental group by bilateral orchiectomy under local anesthesia. At experiment weeks 3, 6, and 9, three rats from each group (experimental and control) were euthanized, their common carotid artery harvested, and routine processing was done for paraffin embedding, sectioning, and staining. The photomicrographs were taken using a digital photomicroscope for morphometric analysis. Orchidectomy resulted in the development of vascular fibrosis, with a significant increase in collagen fiber density and decrease in smooth muscle and elastic fiber density. Moreover, there was development of intimal hyperplasia, with fragmentation of medial elastic lamellae in the common carotid artery of the castrated rats. Orchidectomy induces adverse changes in structure of the common carotid artery of the male rat. These changes may impair vascular function, therefore constituting a possible structural basis for the higher incidences of cardiovascular diseases observed in hypogonadism.

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Section: Discussionsupporting

confidence: 81%

Histomorphological changes in the common carotid artery of the male rat in induced hypogonadism

et al. 2018

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“…The albumin-bound testosterone and unbound or free testosterone represent the major bioavailable male sex steroids [46]. In male mice, testosterone levels were found to be related to an increased left ventricular dimension [47], whereas increasing BMI was associated with decreased SHBG levels [48][49][50]. We speculate that lower SHBG levels in severely obese CP patients might result in an increased bioavailability of the circulating testosterone, which would result in increased LVIDd.…”

Section: Discussionmentioning

confidence: 84%

Cardiac remodeling in patients with childhood-onset craniopharyngioma—results of HIT-Endo and KRANIOPHARYNGEOM 2000/2007

et al. 2021

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Hypothalamic obesity caused by childhood-onset craniopharyngioma results in long-term cardiovascular morbidity. Knowledge about clinical markers and risk factors for cardiovascular morbidity is scarce. A cross-sectional study on transthoracic echocardiographic parameters was performed to determine the associations with clinical and anthropometric parameters in 36 craniopharyngioma patients. BMI correlated with the thickness of interventricular septum in diastole (IVSd) (r = 0.604, p < 0.001) and left ventricular posterior wall thickness in diastole (LVPWd) (r = 0.460, p = 0.011). In multivariate analyses on risk factors for cardiac remodeling, sex hormone replacement therapy, BMI, and male gender were positively correlated with increased left ventricular internal diameter in diastole (LVIDd), R2 = 0.596, F = 10.323, p < 0.001. BMI and insulin resistance were selected as significant independent determinants of IVSd, produced R2 = 0.655, F = 29.441, p < 0.001. Due to a wide range of disease duration, 17 pediatric and 19 adult patients were analyzed separately. In the adult subgroup (age at study ≥ 18 years), BMI correlated with IVSd (r = 0.707, p = 0.003), LVPWd (r = 0.592, p = 0.020), and LVIDd (r = 0.571, p = 0.026). In the pediatric subgroup (age at study < 18 years), no correlation between transthoracic echocardiography (TTE) parameters and BMI was observed. Only LVIDd correlated with disease duration (r = 0.645, p < 0.001). All cardiac functions were within the normal range, indicating no association with functional impairments.Conclusion: Cardiac remodeling in patients with craniopharyngioma correlated with the degree of hypothalamic obesity, disease duration, sex hormone replacement therapy, male gender, and insulin resistance. As echocardiography has limited sensitivity in patients with obesity, further research on more sensitive techniques for cardiac diagnostics in craniopharyngioma patients is warranted. What is Known:•Long-term prognosis in survivors of craniopharyngioma is impaired by obesity and cardiovascular disease.•Associations between echocardiographic findings and clinical and anthropometric parameters after craniopharyngioma are not yet analyzed. What is New:•In patients with childhood-onset craniopharyngioma, cardiac remodeling was associated with hypothalamic obesity, duration of disease, male gender sex hormone replacement, and insulin resistance.•Due to reduced echocardiographic sensitivity caused by obesity-related technical limitations, more sensitive cardiac diagnostics should be considered.

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“…Hence, Dr. Victor suggested that testosterone's effects in patients with heart disease may be detrimental [15]. Cardiac rupture is a lethal complication during the acute stage of myocardial infarction.…”

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confidence: 99%

Reply to the letter “Androgens in cardiac fibrosis and other cardiovascular mechanisms”

Chung

Kao

et al. 2015

International Journal of Cardiology

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Androgens in cardiac fibrosis and other cardiovascular mechanisms

Cited by 18 publications

References 54 publications

Histomorphological changes in the common carotid artery of the male rat in induced hypogonadism

Histomorphological changes in the common carotid artery of the male rat in induced hypogonadism

Cardiac remodeling in patients with childhood-onset craniopharyngioma—results of HIT-Endo and KRANIOPHARYNGEOM 2000/2007

Reply to the letter “Androgens in cardiac fibrosis and other cardiovascular mechanisms”

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