Androgens exacerbate hepatic triglyceride accumulation in rats with polycystic ovary syndrome by downregulating MTTP expression

Wang, Dongxu; Zhao, Han; Xing, Chuan; Lv, Bo; Wang, Xiaochen; He, Bing

doi:10.1007/s12020-023-03590-6

Cited by 2 publications

(1 citation statement)

References 43 publications

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“…Androgens are believed to predispose to liver steatosis through mechanisms that are not yet fully understood. An experimental model in female Sprague Dawley rats by Wang et al showed that hyperandrogenemia (HA) may lead to liver triglyceride accumulation via the downregulation of microsomal triglyceride transfer protein expression [88]. Additionally, estrogens may contribute to abnormal lipid metabolism, as evidenced by their promotion of the production of ApoB100containing lipoproteins by human placental BeWo cells [89].…”

Section: Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 99%

ApoB100 and Atherosclerosis: What’s New in the 21st Century?

Kounatidis,

Vallianou,

Poulaki

et al. 2024

Metabolites

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ApoB is the main protein of triglyceride-rich lipoproteins and is further divided into ApoB48 in the intestine and ApoB100 in the liver. Very low-density lipoprotein (VLDL) is produced by the liver, contains ApoB100, and is metabolized into its remnants, intermediate-density lipoprotein (IDL) and low-density lipoprotein (LDL). ApoB100 has been suggested to play a crucial role in the formation of the atherogenic plaque. Apart from being a biomarker of atherosclerosis, ApoB100 seems to be implicated in the inflammatory process of atherosclerosis per se. In this review, we will focus on the structure, the metabolism, and the function of ApoB100, as well as its role as a predictor biomarker of cardiovascular risk. Moreover, we will elaborate upon the molecular mechanisms regarding the pathophysiology of atherosclerosis, and we will discuss the disorders associated with the APOB gene mutations, and the potential role of various drugs as therapeutic targets.

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Section: Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 99%