Androgens are Fundamental in the Maintenance of Male Sexual Health

Morales, Álvaro

doi:10.1007/s11934-011-0202-4

Cited by 13 publications

(5 citation statements)

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“…In addition to their role in male fertility, androgens are also essential for male sexual health and libido (67). It is not uncommon for males treated with antidiabetic drugs (metformin or pioglitazone) to exhibit decreased libido and fertility, as these drugs suppress testosterone levels in adults (68,69).…”

Section: Discussionmentioning

confidence: 99%

A Cell-Autonomous Molecular Cascade Initiated by AMP-Activated Protein Kinase Represses Steroidogenesis

Abdou

Bergeron

Tremblay

2014

Molecular and Cellular Biology

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bSteroid hormones regulate essential physiological processes, and inadequate levels are associated with various pathological conditions. In testosterone-producing Leydig cells, steroidogenesis is strongly stimulated by luteinizing hormone (LH) via its receptor leading to increased cyclic AMP (cAMP) production and expression of the steroidogenic acute regulatory (STAR) protein, which is essential for the initiation of steroidogenesis. Steroidogenesis then passively decreases with the degradation of cAMP into AMP by phosphodiesterases. In this study, we show that AMP-activated protein kinase (AMPK) is activated following cAMP-to-AMP breakdown in MA-10 and MLTC-1 Leydig cells. Activated AMPK then actively inhibits cAMP-induced steroidogenesis by repressing the expression of key regulators of steroidogenesis, including Star and Nr4a1. Similar results were obtained in Y-1 adrenal cells and in the constitutively steroidogenic R2C cells. We have also determined that maximum AMPK activation following stimulation of steroidogenesis in MA-10 Leydig cells occurs when steroid hormone production has reached a plateau. Our data identify AMPK as a molecular rheostat that actively represses steroid hormone biosynthesis to preserve cellular energy homeostasis and prevent excess steroid production.

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Section: Discussionmentioning

confidence: 99%

A Cell-Autonomous Molecular Cascade Initiated by AMP-Activated Protein Kinase Represses Steroidogenesis

Abdou

Bergeron

Tremblay

2014

Molecular and Cellular Biology

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“…Furthermore, androgens also act peripherally, maintaining the integrity of penile structures and facilitating the erectile mechanisms. 39 Androgen has a role in the regulation of intrapenile vasodilatation. 40 In the present study, 85.7% of T2DM patients with LST had ED versus 31% of those with normal TT.…”

Section: Grmentioning

confidence: 99%

Androgen Deficiency and Erectile Dysfunction in Patients with Type 2 Diabetes

Saghier

Shebl

Fawzy

et al. 2015

Clin Med Insights Endocrinol Diabetes

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BACKGROUNDThe association between type 2 diabetes mellitus (T2DM) and low total serum testosterone (LST) has been identified in several cross-sectional studies.OBJECTIVESTo assess the prevalence of androgen deficiency and erectile dysfunction (ED) and their relation to glycemic control within a sample of Egyptian men with T2DM.RESEARCH DESIGN AND METHODSA cross-sectional study including 70 men having T2DM. Their ages ranged from 30 to 50 years. They were evaluated for symptoms of androgen deficiency and ED, using a validated Arabic-translated Androgen Deficiency in Aging Males questionnaire and five-items version of the International Index of Erectile Function-5, respectively. Total testosterone (TT), glycated hemoglobin (HbA1c), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin were measured for all study subjects. Penile hemodynamics was assessed using penile duplex study for subjects who gave history of ED.RESULTSLST was found in 40% of studied men, and 92.9% of them reported overt symptoms of androgen deficiency. ED was detected in 85.7% of those with LST, as opposed to 31.0% of those with normal TT (P < 0.000). TT was lower in diabetic men with ED compared to those without ED (12.04 ± 5.36 vs 17.11 ± 7.11 nmol/L, P < 0.001). Significant negative correlation was found between TT and age, body mass index, waist circumference, systolic and diastolic blood pressures, and HBA1c (P < 0.00). FSH, LH, and prolactin levels were within the normal reference range in all subjects. HbA1c was higher in patients who had LST with ED, compared to those with normal TT and without ED. However, multivariate logistic regression analysis did not reveal a significant association between HBA1c and LST levels.CONCLUSIONLST, symptoms of androgen deficiency, and ED are common in the studied sample of Egyptian men with T2DM. Inappropriately normal FSH and LH in face of LST may denote a state of hypogonadotropic hypogonadism. HBA1c was found to be more significantly associated with ED than with LST.

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“…Sufficient levels of androgens are crucial for erectile function. Androgens act peripherally, influencing erectile mechanisms by upholding the integrity of penile structures and regulating vasodilation in the penis ( 87 ). Two comprehensive meta-analyses, encompassing 850 diabetic men and 2000 non-diabetic individuals ( 88 ), as well as 1,822 diabetic men and 10,009 non-diabetic individuals, revealed markedly lower total testosterone levels in diabetic men compared to controls ( 89 ).…”

Section: Discussionmentioning

confidence: 99%

Risk factors for erectile dysfunction in diabetes mellitus: a systematic review and meta-analysis

Dilixiati,

Waili,

Tuerxunmaimaiti

et al. 2024

Front. Endocrinol.

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BackgroundPrevious studies have established that diabetes mellitus (DM) markedly raises the risk of developing erectile dysfunction (ED). Despite extensive investigations, the risk factors associated with ED in diabetic men have yet to be unequivocally determined, owing to incongruent and inconclusive results reported in various studies.ObjectiveThe objective of this systematic review and meta-analysis was to assess the risk factors for ED in men with DM.MethodsA comprehensive systematic review was conducted, encompassing studies published in the PubMed, Scopus and Embase databases up to August 24th, 2023. All studies examining the risk factors of ED in patients with DM were included in the analysis. To identify significant variations among the risk factors, odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were employed. The risk of bias was evaluated using the Newcastle-Ottawa Scale(NOS) for longitudinal studies and the Agency for Healthcare Research and Quality Scale(AHRQ) for cross-sectional studies.ResultsA total of 58 studies, including a substantial participant pool of 66,925 individuals diagnosed with DM, both with or without ED, were included in the meta-analysis. Mean age (OR: 1.31, 95% CI=1.24-1.37), smoking status (OR: 1.32, 95% CI=1.18-1.47), HbA1C (OR: 1.44, 95% CI=1.28-1.62), duration of DM (OR: 1.39, 95% CI=1.29-1.50), diabetic neuropathy (OR: 3.47, 95% CI=2.16-5.56), diabetic retinopathy (OR: 3.01, 95% CI=2.02-4.48), diabetic foot (OR: 3.96, 95% CI=2.87-5.47), cardiovascular disease (OR: 1.92, 95% CI=1.71-2.16), hypertension (OR: 1.74, 95% CI=1.52-2.00), microvascular disease (OR: 2.14, 95% CI=1.61-2.85), vascular disease (OR: 2.75, 95% CI=2.35-3.21), nephropathy (OR: 2.67, 95% CI=2.06-3.46), depression (OR: 1.82, 95% CI=1.04-3.20), metabolic syndrome (OR: 2.22, 95% CI=1.98-2.49), and diuretic treatment (OR: 2.42, 95% CI=1.38-4.22) were associated with increased risk factors of ED in men with DM.ConclusionOur study indicates that in men with DM, several risk factors for ED have been identified, including mean age, HbA1C, duration of DM, diabetic neuropathy, diabetic retinopathy, diabetic foot, cardiovascular disease, hypertension, microvascular disease, vascular disease, nephropathy, depression, metabolic syndrome, and diuretic treatment. By clarifying the connection between these risk factors and ED, clinicians and scientific experts can intervene and address these risk factors, ultimately reducing the occurrence of ED and improving patient management.

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Androgens are Fundamental in the Maintenance of Male Sexual Health

Cited by 13 publications

References 63 publications

A Cell-Autonomous Molecular Cascade Initiated by AMP-Activated Protein Kinase Represses Steroidogenesis

A Cell-Autonomous Molecular Cascade Initiated by AMP-Activated Protein Kinase Represses Steroidogenesis

Androgen Deficiency and Erectile Dysfunction in Patients with Type 2 Diabetes

Risk factors for erectile dysfunction in diabetes mellitus: a systematic review and meta-analysis

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