“…Male aggressive behaviors (3, 4) were also severely impaired in AR LϪ/Y mice [ 2 (1) ϭ 10.8, P Ͻ 0.01] as measured by decreased numbers of aggressive bouts (F 7,79 ϭ 6.71, P Ͻ 0.01) with longer latency periods (F 7,79 ϭ 6.55, P Ͻ 0.01). Unexpectedly, treatment with either DHT or a nonaromatizable synthetic AR ligand (R1881) (15) enhanced, to at least some extent, the impaired male aggressive behaviors of AR LϪ/Y mice [DHT, 2(1) ϭ 4.0, P Ͻ 0.05, and R1881, 2(1) ϭ 5.5, P Ͻ 0.05; Fig. 2 b-d].…”