Androgenic regulation of tubulin gene expression in axotomized hamster facial motoneurons

Jones, Kathryn J.; Oblinger, Monica M.

doi:10.1523/jneurosci.14-06-03620.1994

Cited by 74 publications

(75 citation statements)

References 55 publications

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“…Importantly, tubulin mRNAs are upregulated by androgen treatment selectively. While α Itubulin, β II -tubulin, and β III -tubulin are all upregulated by axotomy, only β II -tubulin has been shown to be under the control of androgen in this model (Jones and Oblinger, 1994;Jones et al, 1999b). Tubulin genes are also regulated by androgen in axotomized sciatic motoneurons ) and rubrospinal motoneurons (Storer et al, 2002;DeLucia et al, 2007), and in the spinal nucleus of the bulbocavernosus (SNB; Matsumoto et al, 1993Matsumoto et al, , 1994, a group of motoneurons whose dendritic extension and retraction is under the control of androgens (Fargo and Sengelaub, 2007b;Kurz et al, 1986), raising the possibility that this may be a general phenomenon in motoneurons.…”

Section: Cellular and Molecular Mediatorsmentioning

confidence: 64%

“…First, extrapolation of hamster facial motoneuron axon regeneration data indicates that axon sprouting occurs at about two days post-injury (see Figure 3; Kujawa et al, 1991). Second, androgen treatment enhances axotomy-induced upregulation of β II -tubulin expression between two days and seven days post-injury (Jones and Oblinger, 1994;Jones et al, 1999b). Considered together with the fact that neuritin is an essential mediator of androgen-induced axon outgrowth in NSC34/mAR cells (Marron et al, 2005), these data suggest the hypothesis that neuritin may be involved in coordinating androgen-enhanced axon regeneration in the injured facial nerve.…”

Section: Cellular and Molecular Mediatorsmentioning

confidence: 99%

“…Furthermore, GAP-43 is upregulated by axotomy in the peripheral nervous system, but this response is muted in the central nervous system (Tetzlaff et al, 1991). Injury of the facial motor nerve increases GAP-43 mRNA and protein in the facial nucleus, and androgen treatment augments this response (Coers et al, 2002;Jones et al, 1997a).…”

Section: Cellular and Molecular Mediatorsmentioning

confidence: 99%

“…The primary cytoskeletal structures in axons are microtubules, which are composed of tubulin proteins. Tubulin mRNAs are upregulated in facial motoneurons as the axons regenerate following axotomy (Jones and Oblinger, 1994;Jones et al, 1999b;Tetzlaff et al, 1991); and androgen treatment, which enhances axon regeneration rates, causes an additional upregulation of tubulin mRNAs above axotomy alone (Jones and Oblinger, 1994;Jones et al, 1999b). Importantly, tubulin mRNAs are upregulated by androgen treatment selectively.…”

Section: Cellular and Molecular Mediatorsmentioning

confidence: 99%

“…Testosterone upregulates α-tubulin, β II -tubulin, and β III -tubulin in cultured SH-SY5Y cells in an AR-dependent manner (Butler et al, 2001). In vivo, β II -tubulin expression is upregulated during androgen-enhanced nerve regeneration in axotomized facial (Jones and Oblinger, 1994;Jones et al, 1999b) and sciatic (Brown et al, 1999) motoneurons, and androgens regulate levels of both β-actin and β-tubulin in SNB motoneurons (Matsumoto et al, 1992(Matsumoto et al, , 1993(Matsumoto et al, , 1994.…”

Section: Future Directionsmentioning

confidence: 99%

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Androgen regulation of axon growth and neurite extension in motoneurons

Fargo

Galbiati

Foecking

et al. 2008

Hormones and Behavior

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Androgens act on the CNS to affect motor function through interaction with a widespread distribution of intracellular androgen receptors (AR). This review highlights our work on androgens and process outgrowth in motoneurons, both in vitro and in vivo. The actions of androgens on motoneurons involve the generation of novel neuronal interactions that are mediated by the induction of androgendependent neurite or axonal outgrowth. Here, we summarize the experimental evidence for the androgenic regulation of the extension and regeneration of motoneuron neurites in vitro using cultured immortalized motoneurons, and axons in vivo using the hamster facial nerve crush paradigm. We place particular emphasis on the relevance of these effects to SBMA and peripheral nerve injuries.

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Section: Cellular and Molecular Mediatorsmentioning

confidence: 64%

Section: Cellular and Molecular Mediatorsmentioning

confidence: 99%

Section: Cellular and Molecular Mediatorsmentioning

confidence: 99%

Section: Cellular and Molecular Mediatorsmentioning

confidence: 99%

Section: Future Directionsmentioning

confidence: 99%

See 3 more Smart Citations

Androgen regulation of axon growth and neurite extension in motoneurons

Fargo

Galbiati

Foecking

et al. 2008

Hormones and Behavior

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Dexamethasone for the Prevention of Recurrent Laryngeal Nerve Palsy and Other Complications After Thyroid Surgery

Schietroma¹,

Cecilia²,

Carlei³

et al. 2013

JAMA Otolaryngol Head Neck Surg

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Importance: Recurrent laryngeal nerve dysfunction and hypoparathyroidism are well-recognized, important complications of thyroid surgery. The duration of convalescence after noncomplicated thyroid operation may depend on several factors, of which pain and fatigue are the most important. Nausea and vomiting occur mainly on the day of operation. Glucocorticoids are well known for their analgesic, anti-inflammatory, immunemodulating and antiemetic effects. However, there is little information in the literature on the use of steroids in thyroid surgery, and the information that is available is conflicting.Objective: To investigate whether preoperative dexamethasone could improve surgical outcome in patients undergoing thyroid surgery.Design: A randomized double-blind placebocontrolled trial. A 30-day follow-up for morbidity was performed in all cases.Setting: All patients were hospitalized in a public hospital.Participants: From June 2008 through August 2011, 328 patients were randomized to receive either intravenous dexamethasone, 8 mg, administered 90 minutes before skin incision, or saline solution (placebo).Interventions: Intravenous dexamethasone, 8 mg. Main Outcomes and Measures:The primary end points were temporary or permanent recurrent laryngeal nerve palsy. Transient and definitive hypoparathyroidism, pain and fatigue scores, nausea, and the number of vomiting episodes were also registered. Preoperatively and at several times during the first 24 postoperative hours, we measured C-reactive protein, interleukin 6, and interleukin 1␤ levels.Results: In the dexamethasone group, the rate of temporary recurrent laryngeal nerve palsy (4.9%) was significantly lower compared with the placebo group (8.4%) (P=.04). Also, postoperative transient biochemical hypoparathyroidism occurred more frequently in the placebo group (37.0%) than in the dexamethasone group (12.8%). Dexamethasone use significantly reduced postoperative levels of C-reactive protein (P =.01) and interleukin 6 and interleukin 1␤ (P=.02), fatigue (P=.01), and overall pain during the first 24 postoperative hours (P = .04), as well as the total analgesic (ketorolac tromethamine) requirement (P=.04). Dexamethasone use also reduced nausea and vomiting on the day of operation (P =.045). Conclusions and Relevance:Preoperative administration of dexamethasone, 8 mg, reduced postoperative temporary recurrent laryngeal nerve palsy and hypoparathyroidism rates and reduced pain, fatigue, nausea, and vomiting after thyroid surgery. However, these data require further analysis in randomized prospective studies.Trial Registration: clinicaltrials.gov Identifier: NCT01690806 Otolaryngol Head Neck Surg. 2013;139(5):471-478 T OTAL THYROIDECTOMY OR thyroid lobectomy has been accepted as the current surgical therapy for benign and malignant thyroidal disorders, 1-5 but extensive resection might increase the risk of postoperative complications. JAMA6,7 Recurrent laryngeal nerve (RLN) dysfunction and hypoparathyroidism are well-recognized, important complications of thyro...

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Differential effects of the intraventricular administration of 6-hydroxydopamine on the induction of type II ?-tubulin and tyrosine hydroxylase mRNA in the locus coeruleus of the aging Fischer 344 rat

Unnerstall

Long

1996

J. Comp. Neurol.

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Noradrenergic neurons of the locus coeruleus have been shown to respond to injury by increasing the synthesis of neurotransmitter (via the activation and induction of tyrosine hydroxylase, the rate-limiting catalyst in the production of catecholamines) and initiating compensatory axonal sprouting. However, this laboratory has recently described a significant deficit in the activation of tyrosine hydroxylase in the aged Fischer 344 rat, in contrast to the young and mature rat, following partial damage to cortical and hippocampal noradrenergic terminals induced by the neurotoxin 6-hydroxydopamine. To extend these observations, we measured changes in the relative levels of neuron-specific type II beta-tubulin and tyrosine hydroxylase mRNA in locus coeruleus neurons of 2, 12, and 24-month-old Fischer 344 rats following intraventricular infusions of 6-hydroxydopamine by using in situ hybridization histochemistry. These measures were used as markers of the responsiveness of these neurons to injury. 6-Hydroxydopamine treatment induced a persistent increase (at least 10 days) in the expression of type II beta-tubulin mRNA only in 2-month-old animals; this marker decreased in the 12 and 24-month-old animals. Relative levels of tyrosine hydroxylase mRNA increased in 2 and 12-month-old lesioned animals both 3 and 10 days post-treatment. In contrast, the induction of tyrosine hydroxylase mRNA in 24-month-old animals, seen three days post-treatment, was attenuated by 10 days. These data indicate that the capacity of locus coeruleus neurons to compensate for injury by either initiating a potential sprouting response or increasing their capacity to synthesize neurotransmitter is reduced in older animals.

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Androgenic regulation of tubulin gene expression in axotomized hamster facial motoneurons

Cited by 74 publications

References 55 publications

Androgen regulation of axon growth and neurite extension in motoneurons

Androgen regulation of axon growth and neurite extension in motoneurons

Dexamethasone for the Prevention of Recurrent Laryngeal Nerve Palsy and Other Complications After Thyroid Surgery

Differential effects of the intraventricular administration of 6-hydroxydopamine on the induction of type II ?-tubulin and tyrosine hydroxylase mRNA in the locus coeruleus of the aging Fischer 344 rat

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