Androgenic and male‐inducing effects of 11‐ketotestosterone on a teleost, the medaka (<i>Oryzias latipes</i>)

Hishida, Tomi‐O; Kawamoto, Noriko

doi:10.1002/jez.1401730306

Cited by 60 publications

(22 citation statements)

References 11 publications

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“…This steroid is a common androgen among fishes (Ozon 1972, Fostier et al 1983. Its androgenic potency is greater than that of testosterone (Hishida & Kawamoto 1970), and it is involved in spermatogenesis or spermiation in numerous gonochoristic fishes (Yamazaki & Donaldson 1969, Billard et al 1978, Fostier et al 1981, Fostier et al 1983.…”

Section: Discussionmentioning

confidence: 97%

Histological and ultrastructural evidence for the role of gonadal steroid hormones in sex change in the protogynous wrasse Thalassoma duperrey

et al. 1989

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Section: Discussionmentioning

confidence: 97%

Histological and ultrastructural evidence for the role of gonadal steroid hormones in sex change in the protogynous wrasse Thalassoma duperrey

et al. 1989

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“…In the testis, Leydig cells produce 11-ketotestosterone from testosterone by the action of two enzymes, 11␤-hydroxydehydrogenase 2 (11␤-HSD2) and P45011␤. The administration of 11-ketotestosterone has been shown to cause phenotypic female-to-male sex reversal in the medaka (40).…”

Section: Androgen Is Synthesized In the Adult Cxcr4-morphants Of Bothmentioning

confidence: 99%

Germ cells are essential for sexual dimorphism in the medaka gonad

Kurokawa

Saito

Nakamura

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

265

187

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To further elucidate the roles of germ cells in the sex differentiation of gonads, we have used the medaka, a teleost fish, to generate mutants that lack germ cells from the onset of gonadogenesis by the morpholino-mediated knockdown of cxcr4. The resulting germcell-deficient medaka show female-to-male sex reversal of their secondary sex characteristics, accompanied by increased levels of androgen and reduced levels of estrogen. A failure to maintain granulosa cells or estrogen-producing cells also occurs at early stages of sex differentiation in the cxcr4 morphants, before the initiation of gonadal morphogenesis. In contrast, androgenproducing cells are unaffected in germ-cell-deficient medaka of either sex. In addition, a single tube-like gonad that expresses male-specific genes is formed in these mutants irrespective of the genetic sex. Significantly, each of these mutant phenotypes occurs in a somatic cell-autonomous manner, suggesting that gonadal somatic cells are predisposed toward male development in the absence of germ cells. This highlights the importance of germ cells in the sexual dimorphism of the gonads.sex differentiation ͉ steroidogenic cells ͉ sox9 ͉ foxl2 ͉ aromatase

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“…For example, in female fathead minnows exposed to methyltestosterone, there is a marked induction of dorsal nuptial tubercles normally present only in males (Figure 3; Ankley et al 2001). In medaka, exposure to both natural (11-ketotestosterone) and synthetic (trenbolone) androgens causes females to develop male-like papillary processes on the anal fin (Hishida and Kawamoto 1970;OECD 2004).…”

Section: Partial Life-cycle Reproduction Testsmentioning

confidence: 99%

Small Fish Models for Identifying and Assessing the Effects of Endocrine-disrupting Chemicals

Ankley¹,

Johnson²

2004

ILAR Journal

238

144

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Endocrine-disrupting chemicals (EDCs), particularly those that affect the hypothalamic-pituitary-gonadal (HPG) axis of vertebrates, have become a focus of regulatory screening and testing throughout the world. Small fish species, principally the fathead minnow (Pimephales promelas), Japanese medaka (Oryzias latipes), and zebrafish (Danio rerio), are used as model organisms for several of these testing programs. Fish are appropriate models for testing EDCs, not only from the perspective of existing ecological impacts, but also in terms of species extrapolation. Specifically, there is a significant degree of conservation of basic aspects of the HPG axis across vertebrates, which provides a technically robust basis for using results from fish tests to predict likely modes/mechanisms of action of potential EDCs in other vertebrates. Different experimental designs/endpoints for partial-and full-life cycle tests with fish that enable a consideration of a broad range of EDCs are described. Examples of results with specific chemicals in tests with the fathead minnow, medaka, and zebrafish are presented and discussed in terms of sensitivity and specificity for different classes of EDCs.

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Androgenic and male‐inducing effects of 11‐ketotestosterone on a teleost, the medaka (Oryzias latipes)

Cited by 60 publications

References 11 publications

Histological and ultrastructural evidence for the role of gonadal steroid hormones in sex change in the protogynous wrasse Thalassoma duperrey

Histological and ultrastructural evidence for the role of gonadal steroid hormones in sex change in the protogynous wrasse Thalassoma duperrey

Germ cells are essential for sexual dimorphism in the medaka gonad

Small Fish Models for Identifying and Assessing the Effects of Endocrine-disrupting Chemicals

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