Androgenic adult granulosa cell tumour with prolongation of the activated partial thromboplastin time in a 29 year old woman

Honda, Tsuyoshi; Fukasawa, H; Hashi, Akihiko; Minai, Makiko; Hirata, Shuji; Hoshi, Kazuhiko

doi:10.1046/j.1471-0528.2003.02023.x

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…GCTs exhibits endocrine activity and many features of normal granulosa cells, including FSH-binding, a response to FSH, and the secretion of estrogen, inhibin [2], progesterone, androgen [1,3,4] and Müllerian inhibiting substance [5]. The presentation of an adult GCTs accompanied by endocrinological symptoms is often related to hyperestrogensim and varies according to the age of patient.…”

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confidence: 99%

Androgenic adult granulosa cell tumor with secondary amenorrhea and elevated luteinizing hormone

Niwa¹,

Yano²,

Mori³

et al. 2013

Pathol Discov

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Granulosa cell tumors (GCTs), adult type, are the most common type of ovarian sex cord tumors. Menstrual irregularity, even secondary amenorrhea is frequently observed in premenopausal women bearing GCTs with hormonal activity. We present here in an extremely rare case of adult GCT in a patient presenting with secondary amenorrhea and serum testosterone (Test) and luteinizing hormone (LH) elevations, and decreased estradiol (E 2). A 32-year-old woman visited our hospital complaining of secondary amenorrhea two years after second delivery. Signs of virilisatoin, such as increased pubic hair and clitoromegaly were present. A pelvic ultrasound scan revealed a right adnexal solid mass measuring 2.9x3.9 cm. Under the working diagnosis of sexcord tumor, the woman underwent a laparoscopic surgery of a right salpingo-oophorectomy and the tumor was collected from the Douglas' pouch. The tumor was diagnosed as an adult-type GCT stage IA. Spontaneous menstruation occurred and serum levels of Test, LH, FSH and E 2 showed normal ranges one month after surgery. The patient is now healthy without evidence of a recurrence 30 months after the surgery. Although s-Test and LH elevations in patients with GCT is rare and its mechanism is not clearly understood, monitoring of s-Test and LH may provide an additional tumor marker after conservative surgery in such patients.

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Section: Introductionmentioning

confidence: 99%

Androgenic adult granulosa cell tumor with secondary amenorrhea and elevated luteinizing hormone

Niwa¹,

Yano²,

Mori³

et al. 2013

Pathol Discov

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Androgenic adult granulosa cell tumor in a teenager: a case report and review of the literature

Kabaca¹,

Karateke²,

Gürbüz³

et al. 2006

International Journal of Gynecological Cancer

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The clinicopathologic findings of the third case of androgenic adult granulosa cell tumor in patients younger than 15 years was presented and discussed in the light of the literature. A patient complaining of secondary amenorrhea and hirsutism with elevated levels of plasma total testosterone, dehydroepiandrosterone sulfate, free androgen index and serum inhibin A, and a left ovarian septated, cystic mass was admitted to the hospital. The inhibin A level was within normal levels in the first month postoperatively. Inhibin A could be a tumor marker of utmost importance particularly in patients with androgenic or hyperestrogenic symptoms, especially in cases where benign criteria are abundant such as young age, nonincreased levels of classic tumor markers, and ultrasonographic appearance without any suspicion of malignancy.

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AMH producing purely cystic virilizing adult granulosa cell tumor in 17 years old girl: a case report and review of literatures

et al. 2023

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Background Androgen-producing granulosa cell tumor in adolescent girl is rare condition and clinical characteristics are not fully elucidated. Case presentation Seventeen years old girl complained of secondary amenorrhea was referred to our out-patient consultation. Markedly elevated serum testosterone, LH, and AMH levels were noted. Mild hirsutism and clitoromegaly were presented. Transabdominal ultrasonography and MRI revealed cystic mass occupied pelvic cavity probably originated from left ovary. Right ovary showed polycystic appearance. Laparoscopic left ovarian cystectomy was performed. After the surgery, her menstruation resumed along with normalized hormonal parameters, and clinical hyperandrogenism were improved. Since the scarcity of cellular lining of inner cyst wall, definitive pathological diagnosis was difficult. After the consultation with gynecological pathologist, the tumor was diagnosed as sex cord stromal tumor, highly suspicious for adult granulosa cell tumor. Residual left salpingo-oophorectomy was performed by additional laparoscopic surgery. Her serum testosterone and AMH levels were remained low with regular menstrual cycles and no evidence of recurrence. Conclusions Androgen-producing cystic granulosa cell tumor is rare gynecological disorders, which need both gynecologic oncological and endocrinological approach. Its clinical manifestations may bring some clues to the pathogenesis of ovulatory dysfunctions, such as polycystic ovary syndrome.

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Androgenic adult granulosa cell tumour with prolongation of the activated partial thromboplastin time in a 29 year old woman

Cited by 3 publications

References 10 publications

Androgenic adult granulosa cell tumor with secondary amenorrhea and elevated luteinizing hormone

Androgenic adult granulosa cell tumor with secondary amenorrhea and elevated luteinizing hormone

Androgenic adult granulosa cell tumor in a teenager: a case report and review of the literature

AMH producing purely cystic virilizing adult granulosa cell tumor in 17 years old girl: a case report and review of literatures

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