Androgenic action of Tinospora cordifolia ethanolic extract in prostate cancer cell line LNCaP

Kapur, Priya; Pereira, Ben M. J.; Wuttke, W.; Jarry, Hubertus

doi:10.1016/j.phymed.2008.10.005

Cited by 21 publications

(13 citation statements)

References 6 publications

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“…Androgenic compounds in TCE act via androgen receptor. [69] Newly isolated compounds like (5R, 10R)-4R, 8R-dihydroxy-2S, 3R: 15, 16-diepoxycleroda-13 (16), 17, 12S: 18,1S-dilactone (ECD), a diterpenoid from Tinospora cordifolia has been reported for its chemopreventive potential in diethylnitrosamine (DEN) induced hepatocellular carcinoma (HCC) in rats by decreasing anti-oxidant activities via SOD, CAT and detoxification enzymes like GSH, GPx and subsequent increase in the activities of the hepatic markers ((Serum glutamic oxaloacetic transaminase)SGOT, (Serum Glutamic Pyruvate Transaminase) SGPT, LDH) and decreased serum transaminase level thus confirming its anti-tumor effects and promising application as a potent chemo preventive drug for HCC. [26]…”

Section: Resultsmentioning

confidence: 99%

Tinospora cordifolia: One plant, many roles

2012

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Natural products with medicinal value are gradually gaining importance in clinical research due to their well-known property of no side effects as compared to drugs. Tinospora cordifolia commonly named as “Guduchi” is known for its immense application in the treatment of various diseases in the traditional ayurvedic literature. Recently the discovery of active components from the plant and their biological function in disease control has led to active interest in the plant across the globe. Our present study in this review encompasses (i) the genetic diversity of the plant and (ii) active components isolated from the plant and their biological role in disease targeting. The future scope of the review remains in exploiting the biochemical and signaling pathways affected by the compounds isolated from Tinospora so as to enable new and effective formulation in disease eradication.

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Section: Resultsmentioning

confidence: 99%

Tinospora cordifolia: One plant, many roles

2012

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“…An androgen mimic (e.g., as found in the Indian medicinal herb Tinospora cordifolia; Kapur et al 2009) can be canalized in a different manner. It is well established that T is modified by the enzyme 5-␣-reductase-2 to the more potent DHT in some tissues and this modification is necessary to achieve sufficient androgen signal to induce a malespecific phenotype, e.g., in the external genitals and the internal prostate.…”

Section: Sex Hormone Differences Are Notmentioning

confidence: 99%

Homosexuality as a Consequence of Epigenetically Canalized Sexual Development

Rice

Friberg²,

Gavrilets³

2012

The Quarterly Review of Biology

114

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“…It has been widely used for several centuries in Ayurvedic system of medicine for its general tonic, anti-inflammatory, anti-arthritic, and antimalarial (Rao et al 2008). Variety of components have been isolated from T. cordifolia, such as alkaloids, diterpenoid lactones, phenolics and their glycosides, sesquiterpenoids, steroids, aliphatic compounds, and polysaccharides (Chauhan 1995;Singh et al 2003) and berberine, palmatine, tembertarine, magniflorine, choline, and tinosporin were isolated from its stem (Kapura et al 2009). …”

Section: Introductionmentioning

confidence: 99%

Synthesis of pediculocidal and larvicidal silver nanoparticles by leaf extract from heartleaf moonseed plant, Tinospora cordifolia Miers

Jayaseelan¹,

Rahuman²,

Rajakumar³

et al. 2011

Parasitol Res

210

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Insecticide resistance and inadequate attention to the application instructions of topical pediculicides are common reasons for treatment failure. Essential oils or plant extracts are good and safe alternatives due to their low toxicity to mammals and easy biodegradability. The present study was carried out to establish the pediculocidal and larvicidal activity of synthesized silver nanoparticles (AgNPs) using leaf aqueous extract of Tinospora cordifolia Miers (Menispermaceae) against the head louse Pediculus humanus capitis De Geer (Phthiraptera: Pediculidae) and fourth instar larvae of malaria vector, Anopheles subpictus Grassi and filariasis vector, Culex quinquefasciatus Say (Diptera: Culicidae). We reported the aqueous plant extract and synthesized AgNPs against head lice and vectors. Direct contact method was conducted to determine the potential of pediculocidal activity. The synthesized AgNPs characterized by UV-vis spectrum, scanning electron microscopy, Fourier transform infrared, and X-ray diffraction. Head lice and mosquito larvae were exposed to varying concentrations of aqueous extracts and synthesized AgNPs for 24 h. The results suggest that the optimal times for measuring mortality effects of synthesized AgNPs were 33% at 5 min, 67% at 15 min, and 100% after 1 h. The maximum activity was observed in the synthesized AgNPs against lice, A. subpictus and C. quinquefasciatus (LC(50) = 12.46, 6.43 and 6.96 mg/L; r (2) = 0.978, 0.773 and 0.828), respectively. The findings revealed that synthesized AgNPs possess excellent anti-lice and mosquito larvicidal activity. These results suggest that the green synthesis of AgNPs have the potential to be used as an ideal ecofriendly approach for the control of head lice and vectors.

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Androgenic action of Tinospora cordifolia ethanolic extract in prostate cancer cell line LNCaP

Cited by 21 publications

References 6 publications

Tinospora cordifolia: One plant, many roles

Tinospora cordifolia: One plant, many roles

Homosexuality as a Consequence of Epigenetically Canalized Sexual Development

Synthesis of pediculocidal and larvicidal silver nanoparticles by leaf extract from heartleaf moonseed plant, Tinospora cordifolia Miers

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