Androgenetic alopecia

Abstract

Androgenetic alopecia (AGA) and female pattern hair loss are highly prevalent in our society. In recent years, many strides have been made in understanding the epidemiology and the pathophysiology of this disease; yet, there are few truly effective treatments. In this paper, we review some of the recent research on the epidemiology, pathophysiology, and treatment of AGA. Further studies on genetics, mechanisms of disease, and novel therapies will likely lead to more efficacious treatment and improved outcomes in patients who have AGA and female pattern hair loss.

Titrated extract ofCentella asiaticaincreases hair inductive property through inhibition of STAT signaling pathway in three-dimensional spheroid cultured human dermal papilla cells

“…Unfortunately, with age and undefined factors, the incidence of baldness or alopecia is growing in the worldwide. 29) This dermatological disease relates to important medical and psychosocial matters, because the hair loss affects individual emotions and social perceptions. 30) Therefore, it is important to investigate to understand the molecular mechanisms of hair loss and develop candidates to prevent it.…”

Androgenetic Alopecia: An Overview

“…In South African adults, the incidence of AGA was 14.6% in men and 3.5% in women, although it was a younger population than in other studies. Numerous studies conducted on Asian communities have revealed usually lower rates than those of White groups, with an all-age prevalence of about 20% for men and 5-6% for women [8].…”

“…The AGA onset usually appears between the age of 30-40 years and affects approximately 50% of men by the age of 50 years and 50% of women by the age of 60 years [2]. In all populations, predominance increase with age, however thinning might begin as early as puberty [8]. By the age of 70, less than 15% of males have little to no baldness [9].…”

Androgenetic alopecia: An update

“… 3 AGA's impact on appearance and psychosocial experiences can affect the quality of life (QOL). 4 Despite numerous models exploring AGA pathogenesis, there are only 2 FDA approved treatments (finasteride and minoxidil). 5 …”