Androgenetic alopecia incidence in transgender and gender diverse populations: A retrospective comparative cohort study

Gao, Julia; Sanz, Jessika; Tan, Nicholas; King, Dana; Modest, Anna M.; Dommasch, Erica D.

doi:10.1016/j.jaad.2023.01.037

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…A recent retrospective cohort study of 37,826 patients demonstrated that TGD patients receiving masculinising GAH therapy were 2.5 times more likely to develop AGA as compared to cisgender women. 50 While the literature regarding the treatment of AGA in TGD populations is modest to date, regimens similar to that with the cisgendered population may be recommended. A critical aspect of embarking on AGA treatment is the assessment of patient expectations and realistic treatment goals.…”

Section: Androgenetic Alopeciamentioning

confidence: 99%

“…Notably, this typically masculine feature may be reaffirming in some transmasculine patients but for others, it may be undesirable. A recent retrospective cohort study of 37,826 patients demonstrated that TGD patients receiving masculinising GAH therapy were 2.5 times more likely to develop AGA as compared to cisgender women 50 …”

Section: Dermatological Considerations In Testosterone Therapymentioning

confidence: 99%

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Dermatological considerations for transgender and gender diverse patients: An Australian perspective

Gu,

Tang,

Cheung

et al. 2023

Aust J Dermatology

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Transgender and gender diverse (TGD) individuals are a group that experiences significant health disparities. In the multidisciplinary management of TGD patients, dermatologists may participate in managing skin‐ and hair‐related issues which contribute to gender affirmation and to the cutaneous sequelae of gender‐affirming hormone therapy. This review aims to highlight the unique needs of TGD patients, particularly from the perspective of Australian dermatologists. We review appropriate terminology critical for TGD care, gender affirmation in the Australian healthcare landscape, dermatological considerations for TGD patients and considerations for management.

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Section: Androgenetic Alopeciamentioning

confidence: 99%

Section: Dermatological Considerations In Testosterone Therapymentioning

confidence: 99%

Dermatological considerations for transgender and gender diverse patients: An Australian perspective

Gu,

Tang,

Cheung

et al. 2023

Aust J Dermatology

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Treatment of Common Dermatologic Conditions

Tan,

Vary,

O’Connor

2024

Medical Clinics of North America

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Impaired Arginine Metabolism in Hair Follicles: A Potential Mechanism in Androgenetic Alopecia

Li,

duan,

cheng

et al. 2023

Preprint

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Androgenetic alopecia (AGA) is a prevalent hair loss disorder characterized by an unclear pathogenesis mechanism and limited therapeutic efficacy. Despite a growing body of evidence indicating a link between AGA and metabolic disorders, the precise role of metabolism in AGA development remains elusive. In this study, we employed targeted metabolome profiling to identify distinct metabolic signatures in AGA patients, with a particular focus on amino acid-related metabolic pathways. Notably, our findings highlight a significant decrease in serum abundance of arginine in AGA patients.Locally, impaired arginine metabolism in hair follicles (HFs) experiencing balding was assumed, as evidenced by the heightened expression of ARG1, the pivotal enzyme regulating the arginine-ornithine transition, and the diminished expression of the arginine transporter SLC7A1. Our study further demonstrated that arginine deficiency hinders human hair growth by antagonizing the mTOR signaling pathway. Moreover, the administration of arginine effectively safeguards against the inhibition of hair growth induced by DHT in an AGA-like mouse model and in balding HFs obtained from AGA patients.Collectively, these findings reveal that obstruction of anagen maintenance cause by arginine deficiency occurs in AGA patients and raise the possibility of supplementation with arginine as a promising clinical treatment strategy.

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Androgenetic alopecia incidence in transgender and gender diverse populations: A retrospective comparative cohort study

Cited by 3 publications

References 22 publications

Dermatological considerations for transgender and gender diverse patients: An Australian perspective

Dermatological considerations for transgender and gender diverse patients: An Australian perspective

Treatment of Common Dermatologic Conditions

Impaired Arginine Metabolism in Hair Follicles: A Potential Mechanism in Androgenetic Alopecia

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