Androgenetic alopecia in women and men is not related to COVID‐19 infection severity: a prospective cohort study of hospitalized COVID‐19 patients

Torabi, Shatila; Mozdourian, Mahnaz; Rezazadeh, Roxana; Payandeh, Abolfazl; Badiee, Shapour; Darchini-Maragheh, Emadodin

doi:10.1111/jdv.17353

Cited by 6 publications

(7 citation statements)

References 8 publications

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“…48,49 A follow-up study by the same authors expanded on this data set to include an additional 175 patients who were hospitalized with COVID-19 and reported a similar prevalence of AGA of 67% (72% in men and 49% in women). 45 A separate report by Torabi et al 42 on patients hospitalized with severe COVID-19 in Iran also found a comparable 73.7% prevalence of AGA in men and 56.1% in women; interestingly, the authors of this study found no association between AGA and COVID-19 severity, 42 whereas 3 separate reports found that AGA was associated with increased COVID-19 severity. 16,33,45 After pooling data from these reports, we found that the prevalence of AGA among men with severe COVID-19 requiring hospitalization (n = 449/595, 75.5%) exceeded the expected AGA prevalence of approximately 31% to 53% in men without COVID-19.…”

Section: Aga: Risk Factor For Covid-19mentioning

confidence: 45%

“…An increased prevalence of AGA in patients with severe COVID-19 has been reported by 5 of 6 studies. 14,16,33,42,45 A report found that 71% of patients (n = 41) hospitalized with COVID-19erelated pneumonia in Spain had AGA, 14 compared with an expected prevalence of 31% to 53% in otherwise healthy Spanish Caucasian men. 48,49 A follow-up study by the same authors expanded on this data set to include an additional 175 patients who were hospitalized with COVID-19 and reported a similar prevalence of AGA of 67% (72% in men and 49% in women).…”

Section: Aga: Risk Factor For Covid-19mentioning

confidence: 99%

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Alopecia in patients with COVID-19: A systematic review and meta-analysis

Nguyen

Tosti

2022

JAAD International

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Section: Aga: Risk Factor For Covid-19mentioning

confidence: 45%

Section: Aga: Risk Factor For Covid-19mentioning

confidence: 99%

Alopecia in patients with COVID-19: A systematic review and meta-analysis

Nguyen

Tosti

2022

JAAD International

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“…Similarly, a recent cohort study of hospitalized COVID‐19 patients by Torabi et al. observed no association between COVID‐19 severity and AGA 4 . These findings are, however, in contrast to previous reports by Wambier et al.…”

Section: Resultsmentioning

confidence: 62%

Systematic investigation of a potential epidemiological and genetic association between male androgenetic alopecia and COVID‐19

Henne

Hochfeld

Maj

et al. 2021

Skin Health and Disease

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Background: Male androgenetic alopecia (AGA) has been implicated as a putative risk factor in severe COVID-19 based on high incidences of advanced AGA in male hospitalized COVID-19 patients. Research further suggests that androgen signalling, which plays a central role in AGA aetiology, promotes SARS-CoV-2 infection and is associated with severe COVID-19 symptoms in men. Objectives: We aimed to systematically investigate a potential association between AGA and COVID-19 both on an epidemiological and a genetic level in a large single-population cohort. Methods: We performed regression, genetic correlation and polygenic risk score (PRS) analyses using data from the UK Biobank and published GWAS data on AGA and COVID-19. Results: Our analyses did not reveal any significant epidemiological or genome-wide genetic association between AGA and severe COVID-19. Pathway-based PRS analyses however revealed a significant association in specific pathways, namely vitamin metabolism, natural killer cell-mediated cytotoxicity, WNT signalling and aryl hydrocarbon receptor signalling. Limitations: We restricted our analyses to the white British population and used self-reported AGA status. Sample size may be a limitation in our regression and PRS analyses. Conclusions: Our data yield no evidence for an epidemiological association between AGA and COVID-19 but suggest that a shared genetic basis for both traits exists in specific pathways.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…The Gabrin sign suggests that patients with higher degree of male pattern baldness are at higher risk of developing severe COVID-19 symptoms and requiring hospitalisation [7,8]. This has, however, been argued against, and it has been suggested by few studies and genetic association analysis, that patterned baldness in both women and men is not related to COVID-19 severity [4,9,10].…”

Section: Discussionmentioning

confidence: 99%

“…Androgenetic alopecia has been suggested to be a poor prognostic factor for severe COVID-19 infection in some studies [7,8]. However, results from recent studies refute this observation [9,10]. Alopecia areata (including totalis and universalis) may be exacerbated or induced by COVID-19 infection.…”

Section: Introductionmentioning

confidence: 99%

A prospective cross-sectional study on post COVID-19 hair loss at a tertiary care hospital

Wadhwa

Monga

Kumar

et al. 2023

Preprint

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Severe acute respiratory virus syndrome coronavirus 2 (SARS-CoV-2) was responsible for coronavirus disease (COVID-19) pandemic, which resulted in global health care crisis. As patients recovered from COVID-19 infection, hair loss was increasingly observed as a distressing symptom. We conducted a prospective cross-sectional study of patients presenting with post COVID-19 hair loss between July to December 2021 at a tertiary care centre in north India. Detailed history, clinical examination, trichoscopy and biochemical tests were performed and recorded. COVID-19 disease severity was assessed based on the duration of COVID-19 infection and place of management (home or hospitalized). The study included 120 patients with mean age being 39.6 years. There was female preponderance. Majority of the patients (87%) were treated at home and 43.3% had COVID-19 infection for >2 weeks. Mean visual analog scale (VAS) score for stress was 5.25. Vitamin D deficiency was present in 56.7% and low ferritin in 30% of cases. Mean time of onset of hair loss post COVID-19 was 49 days. Patients mainly presented with diffuse (72.4%) and patterned hair loss (31.6%). Trichodynia was present in 15.8% of cases. The degree of hair loss was severe in 55.8% of the subjects, predominantly in older age group and females. Positive hair pull test was seen in 65% of patients. Most common trichoscopic features included single hair follicles’ (81.7%) and vellus hair >10% (60%). Trichoscopy can aid in unmasking co-existing patterned hair loss in patients presenting clinically with diffuse hair loss. Patients with COVID-19 infection for > 2 weeks had significantly more severe hair loss and VAS score. Trichoscopic findings of vellus hair >10% and empty hair follicles were more frequent in patients who were hospitalized for COVID-19 infection.

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Androgenetic alopecia in women and men is not related to COVID‐19 infection severity: a prospective cohort study of hospitalized COVID‐19 patients

Cited by 6 publications

References 8 publications

Alopecia in patients with COVID-19: A systematic review and meta-analysis

Alopecia in patients with COVID-19: A systematic review and meta-analysis

Systematic investigation of a potential epidemiological and genetic association between male androgenetic alopecia and COVID‐19

A prospective cross-sectional study on post COVID-19 hair loss at a tertiary care hospital

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