Androgen Treatment and Muscle Strength in Elderly Men: A Meta‐Analysis

Ottenbacher, Kenneth J.; Ottenbacher, Margaret E.; Ottenbacher, Allison; Alfaro, Ana; Ostir, Glenn V.

doi:10.1111/j.1532-5415.2006.00938.x

Cited by 156 publications

(112 citation statements)

References 36 publications

Supporting

Mentioning

107

Contrasting

Unclassified

Order By: Relevance

“…These results can be reinforced by data found in the literature, as found in Xu et al (2013)) that conducted a meta-analysis looking for cardiovascular side effects of testosterone replacement and found significant improvements in lean body mass. Ottenbacher et al (2006)) also found increases in muscle strength in another meta-analysis, although the study was not looking specifically to muscle mass.…”

Section: Discussionmentioning

confidence: 93%

See 1 more Smart Citation

Effects of testosterone on lean mass gain in elderly men: systematic review with meta-analysis of controlled and randomized studies

Neto

Gama

Rocha

et al. 2015

AGE

View full text Add to dashboard Cite

The objective of this study was to evaluate the effects of steroid anabolic androgenic hormones use on lean mass gain in elderly men through a systematic review with a meta-analysis of randomized controlled studies. We systematically searched PubMed database until 4th October 2013. We included randomized placebo-controlled trials (RCT) that studied testosterone replacement therapy in men over 60 years of age, with total testosterone levels ≤550 ng/dl, observing gains in weight, lean mass tissue and fat mass as outcome. We excluded duplicated studies, studies which mixed men and women, and studies using weak androgens such as dehydroepiandrosterone or androstenedione. The initial search yielded 2681 articles, of which 26 were selected for full text analysis. In the end, 11 studies were included. However, 3 studies were not included in the metaanalysis. Meta-analysis showed that mean weight increased (lean mass), ranging from 1.65 (95 % CI, AGE (2015) ) kg, although it was heterogeneous (I 2 =98 %). Effect estimate was 3.59 [2.38-4.81]. Androgen therapy decreased fat mass; effect estimate was −1.78 [−2.57, −0.99] that analysis had also a high level of heterogeneity (I 2 =81 %). The results suggest that testosterone replacement therapy is able to increase muscle mass in elderly men and that is affected by the time that the treatment is carried out and the method of administration of the drug.

show abstract

Section: Discussionmentioning

confidence: 93%

“…There are some meta-analysis studies that evaluated the effects of hormone replacement therapy in the elderly that showed positive results (Ottenbacher et al 2006;Yang et al 2013). Isidori et al (2005)) in another metaanalysis study reported beneficial effects enough to justify the demand for other interventional studies on this issue.…”

Section: Discussionmentioning

confidence: 99%

Effects of testosterone on lean mass gain in elderly men: systematic review with meta-analysis of controlled and randomized studies

Neto

Gama

Rocha

et al. 2015

AGE

View full text Add to dashboard Cite

show abstract

“…It has emerged as a potential therapeutic agent for muscle loss associated with ageing and systemic disease. A meta-analysis of 11 randomized controlled trials has provided strong evidence that testosterone supplementation increases muscle strength in elderly men (5). Bhasin et al (1) have demonstrated that the increase in muscle mass and strength from testosterone supplementation is dose dependent in men.…”

Section: Introductionmentioning

confidence: 99%

Oral low-dose testosterone administration induces whole-body protein anabolism in postmenopausal women: a novel liver-targeted therapy

Birzniece

Umpleby

Poljak

et al. 2013

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: In hypopituitary men, oral delivery of unesterified testosterone in doses that result in a solely hepatic androgen effect enhances protein anabolism during GH treatment. In this study, we aimed to determine whether liver-targeted androgen supplementation induces protein anabolism in GH-replete normal women. Design: Eight healthy postmenopausal women received 2-week treatment with oral testosterone at a dose of 40 mg/day (crystalline testosterone USP). This dose increases portal concentrations of testosterone, exerting androgenic effects on the liver without a spillover into the systemic circulation. Outcome measures: The outcome measures were whole-body leucine turnover, from which leucine rate of appearance (LRa, an index of protein breakdown) and leucine oxidation (Lox, a measure of irreversible protein loss) were estimated, energy expenditure and substrate utilization. We measured the concentration of liver transaminases as well as of testosterone, SHBG and IGF1. Results: Testosterone treatment significantly reduced LRa by 7.1G2.5% and Lox by 14.6G4.5% (P!0.05). The concentration of liver transaminases did not change significantly, while that of serum SHBG fell within the normal range by 16.8G4.0% and that of IGF1 increased by 18.4G7.7% (P!0.05). The concentration of peripheral testosterone increased from 0.4G0.1 to 1.1G0.2 nmol/l (P!0.05), without exceeding the upper normal limit. There was no change in energy expenditure and fat and carbohydrate utilization. Conclusions: Hepatic exposure to unesterified testosterone by oral delivery stimulates protein anabolism by reducing protein breakdown and oxidation without inducing systemic androgen excess in women. We conclude that a small oral dose of unesterified testosterone holds promise as a simple novel treatment of protein catabolism and muscle wasting.

show abstract

“…There are substances that have an anabolic effect on muscle and could potentially counteract the formation of interfiber gaps induced by atrophy, which are known to be filled with fat. Several pharmacological substances influence the development, growth, and repair mechanisms of muscle, namely, anabolic steroids [11][12][13][14][15][16][17][18][19][20] , growth hormones [21][22][23][24] , b-2 agonists, heparan sulfate 25 , xanthine derivatives 26 , creatine 27 , and vitamin D 28 . Of all of these substances, anabolic steroids seem best suited for clinical application.…”

mentioning

confidence: 99%

Anabolic Steroids Reduce Muscle Damage Caused by Rotator Cuff Tendon Release in an Experimental Study in Rabbits

Gerber

Meyer

Nuss

et al. 2011

Journal of Bone and Joint Surgery

View full text Add to dashboard Cite

To our knowledge, this is the first documentation of partial prevention of important muscle alterations after retraction of the supraspinatus musculotendinous unit caused by tendon disruption. Nandrolone decanoate administration in the phase after tendon release prevented fatty infiltration of the supraspinatus muscle and reduced functional muscle impairment caused by myotendinous retraction in this rabbit rotator cuff model, but two of seven rabbits that received the drug developed infections. Background: Muscles of the rotator cuff undergo retraction, atrophy, and fatty infiltration after a chronic tear, and a rabbit

show abstract

Androgen Treatment and Muscle Strength in Elderly Men: A Meta‐Analysis

Abstract: The results suggest that testosterone/DHT therapy produced a moderate increase in muscle strength in men participating in 11 randomized trials. One study influenced the mean effect size.

Cited by 156 publications

References 36 publications

Effects of testosterone on lean mass gain in elderly men: systematic review with meta-analysis of controlled and randomized studies

Effects of testosterone on lean mass gain in elderly men: systematic review with meta-analysis of controlled and randomized studies

Oral low-dose testosterone administration induces whole-body protein anabolism in postmenopausal women: a novel liver-targeted therapy

Anabolic Steroids Reduce Muscle Damage Caused by Rotator Cuff Tendon Release in an Experimental Study in Rabbits

Contact Info

Product

Resources

About