Androgen Replacement in Men with Hypogonadism and Erectile Dysfunction

Albrecht-Betancourt, Marion; Hijazi, Rabih; Cunningham, Glenn R.

doi:10.1385/endo:23:2-3:143

Cited by 11 publications

(6 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, the subjects in these studies were mostly middle aged or elderly [1][2][3]18]. There is agreement however, that testosterone levels decline progressively with advancing age and that many of the physiological changes including anxiety and quality of life occur as people age [1,21,22]. Our results, which show a significant increase in depression scores of patients with CHH, are utmost important, as they are performed in a highly specific and homogeneous population of young and treatment naïve hypogonadal subjects.…”

Section: Discussionmentioning

confidence: 61%

Increased frequency of anxiety, depression, quality of life and sexual life in young hypogonadotropic hypogonadal males and impacts of testosterone replacement therapy on these conditions

et al. 2012

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 61%

Increased frequency of anxiety, depression, quality of life and sexual life in young hypogonadotropic hypogonadal males and impacts of testosterone replacement therapy on these conditions

et al. 2012

View full text Add to dashboard Cite

“…Albrecht‐Betancourt et al. [85] have proposed that the prevalence of hypogonadism and ED increases with age, and hypogonadism is frequently associated with decreased libido and ED. Testosterone replacement therapy for hypogonadal ED is effective in restoring sexual desire and erectile function, especially in younger and healthier men.…”

Section: What Is the Evidence For A Role Of Androgens In Human Penilementioning

confidence: 99%

“…Svartberg et al [83,84] have observed that the administration of low-dose testosterone to men with chronic obstructive pulmonary disease for 26 weeks was associated with an improvement of body composition, along with a better erectile function and sexual quality of life. Albrecht-Betancourt et al [85] have proposed that the prevalence of hypogonadism and ED increases with age, and hypogonadism is frequently associated with decreased libido and ED. Testosterone replacement therapy for hypogonadal ED is effective in restoring sexual desire and erectile function, especially in younger and healthier men.…”

Section: Androgen-supplementation In Hypogonadal Patients Improves Ermentioning

confidence: 99%

Are Androgens Critical for Penile Erections in Humans? Examining the Clinical and Preclinical Evidence

Traish

Guay

2006

The Journal of Sexual Medicine

169

121

View full text Add to dashboard Cite

Androgens are deemed critical for penile-tissue development, growth, and maintenance of erectile function, however, their role in erection, especially in humans, remains controversial. In this review, we summarize information from clinical and animal model studies to provide a comprehensive and rational argument for the role of androgens, or lack thereof, on penile erection ability in humans. The goal of this review is to present the clinical and preclinical evidence available in the literature with regard to testosterone and erectile physiology and engage the reader in this discussion. Ultimately, each reader will have to form his or her own conclusions based on the existing evidence. In humans, androgen-deficiency manifestations are noted in clinical situations such as: (i) inadequate development of the penis; and (ii) loss of erectile function in prostate cancer and benign prostatic hyperplasia patients managed with medical or surgical castration or antiandrogen therapy. Androgen treatment causes: (i) improvement in sexual function in hypogonadal patients treated with androgen supplementation; (ii) improvement in nocturnal penile tumescence in hypogonadal patients treated with androgens; (iii) improvement in erectile function with androgen supplementation in patients who did not respond to phosphodiesterase type 5 inhibitor therapy initially; and (iv) improvement in the well-being, mood, energy, and sexual function in aging men who have testosterone deficiency treated with androgen therapy. In contrast to animals, especially rodents in which the adrenal cortex does not synthesize androgens, the human adrenal is a source of peripherally circulating androgen precursors, thus, complete androgen insufficiency may not be observed in men at a younger age. Furthermore, in light of the concept that a threshold of androgen levels exists in animals and humans below which sexual function is diminished, further contributes to the complexity of understanding androgens role in erections, especially in humans. Nevertheless, based on the preclinical and clinical data available in the literature, to date, we infer that androgens play a critical role in maintaining erectile physiology in humans.

show abstract

“…Androgens are important sex hormones in the regulation of male sexual function, including sexual desire and erectile function [3]. It has been reported that hypogonadism is frequently related to ED and testosterone replacement has shown beneficial effects on erectile function [134][135][136].…”

Section: Hypogonadismmentioning

confidence: 99%

RhoA/Rho-kinase in erectile tissue: mechanisms of disease and therapeutic insights

Jin

Burnett

2006

Clinical Science

View full text Add to dashboard Cite

Penile erection is a complicated event involving the regulation of corpus cavernosal smooth muscle tone. Recently, the small monomeric G-protein RhoA and its downstream effector Rho-kinase have been proposed to be important players for mediating vasoconstriction in the penis. RhoA/Rho-kinase increases MLC (myosin light chain) phosphorylation through inhibition of MLCP (MLC phosphatase) thereby increasing Ca2+ sensitivity. This review will outline the RhoA/Rho-kinase signalling pathway, including the upstream regulators, guanine nucleotide exchange factors, GDP dissociation inhibitors and GTPase-activating proteins. We also summarize the current knowledge about the physiological roles of RhoA/Rho-kinase in both male and female erectile tissues and its aberrations contributing to erectile dysfunction in several disease states. Understanding the RhoA/Rho-kinase signalling pathway in the regulation of erection is important for the development of therapeutic interventions for erectile dysfunction.

show abstract

Androgen Replacement in Men with Hypogonadism and Erectile Dysfunction

Cited by 11 publications

References 42 publications

Increased frequency of anxiety, depression, quality of life and sexual life in young hypogonadotropic hypogonadal males and impacts of testosterone replacement therapy on these conditions

Increased frequency of anxiety, depression, quality of life and sexual life in young hypogonadotropic hypogonadal males and impacts of testosterone replacement therapy on these conditions

Are Androgens Critical for Penile Erections in Humans? Examining the Clinical and Preclinical Evidence

RhoA/Rho-kinase in erectile tissue: mechanisms of disease and therapeutic insights

Contact Info

Product

Resources

About