Androgen regulates development of the sexually dimorphic gastrin-releasing peptide neuron system in the lumbar spinal cord: Evidence from a mouse line lacking androgen receptor in the nervous system

Sakamoto, Hirotaka; Saito, Kazuhiro; Marie-Luce, Clarisse; Raskin, Kalina; Oti, Takumi; Satoh, Keita; Tamura, Kei; Sakamoto, Tatsuya; Mhaouty-Kodja, Sakina

doi:10.1016/j.neulet.2013.10.068

Cited by 14 publications

(26 citation statements)

References 22 publications

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“…Immunohistochemical studies in the lumbosacral spinal cord also demonstrated the expression of AR in the cellular nuclei of SNB motoneurons in controls but not in AR NesCre males (Raskin et al, 2012). However, loss of AR expression in the nervous system caused a significant decrease in the number of GRP-immunoreactive neurons compared with that in control littermates (Sakamoto et al, 2014). Consequently, the intensity of GRP axonal projections to the lower spinal cord (L5–L6 and S1 level) was greater in control males than that in AR NesCre males (Sakamoto et al, 2014).…”

Section: Interaction Of the Grp System With Both The Autonomic And Somentioning

confidence: 99%

“…However, loss of AR expression in the nervous system caused a significant decrease in the number of GRP-immunoreactive neurons compared with that in control littermates (Sakamoto et al, 2014). Consequently, the intensity of GRP axonal projections to the lower spinal cord (L5–L6 and S1 level) was greater in control males than that in AR NesCre males (Sakamoto et al, 2014). Taken together, these results suggested that nervous system AR participates in both morphological differentiation and adult activation of SNB motoneurons, but not directly in the survival of SNB motoneurons during neonatal development (Raskin et al, 2012).…”

Section: Interaction Of the Grp System With Both The Autonomic And Somentioning

confidence: 99%

“…In contrast, ARs expressed in the nervous system play critical roles in the development as well as in the maintenance of GRP neurons in the lumbosacral spinal cord in males. The AR -deletion mutation may attenuate sexual behavior and activity of mutant males via spinal GRP system-mediated neural mechanisms (Raskin et al, 2009; Sakamoto et al, 2014). …”

Section: Interaction Of the Grp System With Both The Autonomic And Somentioning

confidence: 99%

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Sexually dimorphic nuclei in the spinal cord control male sexual functions

Sakamoto

2014

Front. Neurosci.

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Lower spinal cord injuries frequently cause sexual dysfunction in men, including erectile dysfunction and an ejaculation disorder. This indicates that the important neural centers for male sexual function are located within the lower spinal cord. It is interesting that the lumbar spinal segments contain several neural circuits, showing a clear sexually dimorphism that, in association with neural circuits of the thoracic and sacral spinal cord, are critical in expressing penile reflexes during sexual behavior. To date, many sex differences in the spinal cord have been discovered. Interestingly, most of these are male dominant. Substantial evidence of sexually dimorphic neural circuits in the spinal cord have been reported in many animal models, but major issues remain unknown. For example, it is not known how the different circuits cooperatively function during male sexual behavior. In this review, therefore, the anatomical and functional significance of the sexually dimorphic nuclei in the spinal cord corresponding to the expression of male sexual behavior is discussed.

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Section: Interaction Of the Grp System With Both The Autonomic And Somentioning

confidence: 99%

Section: Interaction Of the Grp System With Both The Autonomic And Somentioning

confidence: 99%

Section: Interaction Of the Grp System With Both The Autonomic And Somentioning

confidence: 99%

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Sexually dimorphic nuclei in the spinal cord control male sexual functions

Sakamoto

2014

Front. Neurosci.

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“…Neuroanatomical analyses of sexually dimorphic populations in brain areas underlying reproductive behaviors strongly suggest that the neural AR is not involved in their perinatal organization, but can rather mediate their activation during adulthood (Marie-Luce et al, 2013;Picot et al, 2014). In the spinal sites involved in erection and ejaculation, the neural AR plays a key role in postnatal differentiation and adult maintenance of the spinal nucleus of the bulbocavernosus and gastrin-releasing peptide neuron systems (Raskin et al, 2012;Sakamoto et al, 2014). These data are in good agreement with the ontogeny of AR expression showing that this receptor is expressed after the perinatal period in both brain and spinal areas underlying male-typical behavior (Juntti et al, 2010;Smith et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Revisiting the neural role of estrogen receptor beta in male sexual behavior by conditional mutagenesis

Naulé

Marie-Luce

Parmentier

et al. 2016

Hormones and Behavior

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Estradiol derived from neural aromatization of gonadal testosterone plays a key role in the 27 perinatal organization of the neural circuitry underlying male sexual behavior. The aim of this 28 study was to investigate the contribution of neural estrogen receptor (ER)  in estradiol-29 induced effects without interfering with its peripheral functions. For this purpose, male mice 30 lacking ER in the nervous system were generated. Analyses of males in two consecutive 31 tests with a time interval of two weeks showed an effect of experience, but not of genotype, 32 on the latencies to the first mount, intromission, pelvic thrusting and ejaculation. Similarly, 33there was an effect of experience, but not of genotype, on the number of thrusts and mating 34 length. Neural ER deletion had no effect on the ability of males to adopt a lordosis posture in 35 response to male mounts, after castration and priming with estradiol and progesterone.

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“…Again, this suggests that neural AR mediates the postnatal, but not perinatal, effects of testosterone. Neural AR was also found to regulate gastrin-releasing peptide expression, as evidenced by the lower neuron number and intensity of axonal projections in neural AR knock-out male mice (Sakamoto et al, 2014). Whether this regulation involves developmental or adult AR effects is not known.…”

Section: Copulatory Behaviormentioning

confidence: 99%

Role of the androgen receptor in the central nervous system

Mhaouty-Kodja

2018

Molecular and Cellular Endocrinology

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The involvement of gonadal androgens in functions of the central nervous system was suggested for the first time about half a century ago. Since then, the number of functions attributed to androgens has steadily increased, ranging from regulation of the hypothalamic-pituitary-gonadal axis and reproductive behaviors to modulation of cognition, anxiety and other non-reproductive functions. This review focuses on the implication of the neural androgen receptor in these androgen-sensitive functions and behaviors.

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Androgen regulates development of the sexually dimorphic gastrin-releasing peptide neuron system in the lumbar spinal cord: Evidence from a mouse line lacking androgen receptor in the nervous system

Cited by 14 publications

References 22 publications

Sexually dimorphic nuclei in the spinal cord control male sexual functions

Sexually dimorphic nuclei in the spinal cord control male sexual functions

Revisiting the neural role of estrogen receptor beta in male sexual behavior by conditional mutagenesis

Role of the androgen receptor in the central nervous system

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