Androgen receptor trinucleotide repeat polymorphism and personality traits

Abstract

Human family and twin studies have established considerable heritable components influencing individual differences in personality traits as assessed by self-report questionnaires. We have investigated a trinucleotide repeat polymorphism in the androgen receptor gene and personality traits. Healthy Swedish subjects (n = 335) were assessed with the Karolinska Scales of Personality inventory. There were tendencies (P > or = 0.006) in some scales indicating possible relationships between the androgen receptor allele length and personality traits related to dominance and aggression. However, after correction for multiple testing, no significant differences were found. We conclude that no significant association could be found between the androgen receptor polymorphism investigated and any personality trait, although the tendencies found are worthwhile subjects for replication attempts.

Genetic Polymorphisms and Personality in Healthy Adults: A systematic review and meta-analysis

“…25 In the case of five studies, correspondence with the authors indicated that it would not be possible to include their data in the metaanalysis. [26][27][28][29][30] In one case, the ethical approval granted to the study did not allow the data to be released 31 and in one case there was no response from the authors. 32 For each study, the following data were extracted: Data were extracted separately for papers where data on more than one gene, or more than one personality scale, were reported.…”

“…[7][8][9][11][12][13][14][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] The characteristics of the studies are described in Table 1. Of these studies, 33 were not included in the metaanalysis.…”

Association between a dinucleotide repeat polymorphism of the estrogen receptor alpha gene and personality traits in women

“…5,30,31 The KSP consists of 135 items forming 15 subscales and measuring relatively stable personality traits. These subscales are often classified into four factors covering different dimensions of temperament: 'neuroticism', 'psychoticism', non-conformity', and 'extraversion'.…”

“…These subscales are often classified into four factors covering different dimensions of temperament: 'neuroticism', 'psychoticism', non-conformity', and 'extraversion'. [31][32][33] Inter-individual variations in several of the KSP scales have been shown to be partly heritable. 2 All KSP personality test scores were standardized using normative data to have an expected mean7SD of 50710 ( ¼ T-scores).…”

Androgen receptor gene polymorphisms are associated with aggression in Japanese Akita Inu

“…It was reasonable that male dogs possessing a short CAG repeat, whose AR responsivity is assumed to be increased according to human studies, had higher aggressiveness scores than dogs with relatively long alleles. These data broaden our knowledge about the influence of the AR gene on men's behaviour [8,12,13] by providing a valid animal model. No evidence was found for a relationship between AR gene variants and personality in female dogs.…”