Androgen receptor gene sequence and basal cortisol concentrations predict men's hormonal responses to potential mates

Roney, James R.; Simmons, Zachary L.; Lukaszewski, Aaron W.

doi:10.1098/rspb.2009.1538

Cited by 56 publications

(55 citation statements)

References 48 publications

(78 reference statements)

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“…In addition, OPRM1 and HTR2A have been associated with variation in mate-choice success differentially in the sexes in "speed-dating" situations (42). Furthermore, AR variation has been associated with relationship status and testosterone response in opposite-sex interactions (43,44). Here, we examine variation in these genes in relation to both romantic relationship quality [Relationship Assessment Scale (RAS)] and sexual attitudes and behaviors [Sociosexual Orientation Inventory Revised (SOI-R)] more generally.…”

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confidence: 99%

Variation in the β-endorphin, oxytocin, and dopamine receptor genes is associated with different dimensions of human sociality

Pearce

Wlodarski

Machin

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

113

137

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There is growing evidence that the number and quality of social relationships have substantial impacts on health, well-being, and longevity, and, at least in animals, on reproductive fitness. Although it is widely recognized that these outcomes are mediated by a number of neuropeptides, the roles these play remain debated. We suggest that an overemphasis on one neuropeptide (oxytocin), combined with a failure to distinguish between different social domains, has obscured the complexity involved. We use variation in 33 SNPs for the receptor genes for six well-known social neuropeptides in relation to three separate domains of sociality (social disposition, dyadic relationships, and social networks) to show that three neuropeptides (β-endorphin, oxytocin, and dopamine) play particularly important roles, with each being associated predominantly with a different social domain. However, endorphins and dopamine have a much wider compass than oxytocin (whose effects are confined to romantic/reproductive relationships and often do not survive control for other neuropeptides). In contrast, vasopressin, serotonin, and testosterone play only limited roles.

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mentioning

confidence: 99%

Variation in the β-endorphin, oxytocin, and dopamine receptor genes is associated with different dimensions of human sociality

Pearce

Wlodarski

Machin

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

113

137

View full text Add to dashboard Cite

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“…within 15-45 min. from the onset of the interactions) increases in men"s testosterone in controlled laboratory experiments (e.g., Roney et al, 2003Roney et al, , 2007Roney et al, , 2010van der Meij et al, 2008), with such effects also corroborated under more naturalistic field conditions (Flinn et al, 2012). These reactive hormone increases may act as signals of the current importance of mate pursuit, and promote output responses that promote mate competition over short-term time-scales (for reviews of this argument, see Roney, 2009Roney, , 2016.…”

Section: Accepted Manuscriptmentioning

confidence: 87%

Theoretical frameworks for human behavioral endocrinology

Roney

2016

Hormones and Behavior

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How can we best discover the ultimate, evolved functions of endocrine signals within the field of human behavioral endocrinology? Two related premises will guide my proposed answer. First, hormones typically have multiple, simultaneous effects distributed throughout the brain and body, such that in an abstract sense their prototypical function is the coordination of diverse outcomes. Second, coordinated output effects are often evolved, functional responses to specific eliciting conditions that cause increases or decreases in the relevant hormones. If we accept these premises, then a natural way to study hormones is to hypothesize and test how multiple eliciting conditions are mapped into coordinated output effects via hormonal signals. I will call these input-output mappings "theoretical frameworks." As examples, partial theoretical frameworks for gonadal hormones will be proposed, focusing on the signaling roles of testosterone in men and on estradiol and progesterone in women. Recent research on oxytocin in humans will also be considered as an example in which application of the theoretical framework approach could be especially helpful in making functional sense of the diverse array of findings associated with this hormone. The theoretical framework approach is not especially common in the current literature, with many theories having eschewed explicit consideration of input-output mappings in favor of parsimony-based arguments that attempt to find the one main thing that a hormone does with respect to psychology or behavior. I will argue that these parsimony-based models have many shortcomings, and conclude that the construction and testing of theoretical frameworks provides a better means of discovering the evolved functions of human endocrine signals.

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“…-704-social interactions with young women (Roney, Lukaszewski, and Simmons, 2007;Roney, Mahler, and Maestripieri, 2003;Roney, Simmons, and Lukaszewski, 2010;van der Meij, Buunk, van de Sande, and Salvador, 2008). Chemosensory stimuli such as female urine or vaginal secretions are sufficient to trigger these testosterone increases in many nonhuman species (e.g., Cerda-Molina, et al, 2006;James, Nyby, and Saviolakis, 2006;Macrides, Bartke, Fernandez, and D'Angelo, 1974;Ziegler, Schultz-Darken, Scott, Snowdon, and Ferris, 2005), which at least raises the possibility of similar chemical communication in humans.…”

Section: Introductionmentioning

confidence: 99%

Men Smelling Women: Null Effects of Exposure to Ovulatory Sweat on Men's Testosterone

Roney

Simmons

2012

Evol Psychol

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Males of many species, humans included, exhibit rapid testosterone increases after exposure to conspecific females. Female chemical stimuli are sufficient to trigger these responses in many nonhuman species, which raises the possibility of similar effects in humans. Recently, Miller and Maner (2010) reported that smelling T-shirts worn by women near ovulation can trigger testosterone responses in men; however, men were aware that they were smelling women's scents, and thus mental imagery associated with that knowledge may have contributed to the hormone responses. Here, we collected axillary sweat samples from women on days near ovulation. In a crossover design, men who were not explicitly aware of the specific stimuli smelled the sweat samples in one session and water samples in a second session. There were no differences in testosterone responses across the experimental conditions. Our null findings suggest that the relevant chemical signal is not found in axillary sweat, and/or that knowledge of the stimulus source is necessary for hormone responses. These results thus suggest boundary conditions for the effects reported in Miller and Maner (2010), and recommend further research to define the precise circumstances under which men's testosterone may respond to chemosensory cues from women.

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Androgen receptor gene sequence and basal cortisol concentrations predict men's hormonal responses to potential mates

Cited by 56 publications

References 48 publications

Variation in the β-endorphin, oxytocin, and dopamine receptor genes is associated with different dimensions of human sociality

Variation in the β-endorphin, oxytocin, and dopamine receptor genes is associated with different dimensions of human sociality

Theoretical frameworks for human behavioral endocrinology

Men Smelling Women: Null Effects of Exposure to Ovulatory Sweat on Men's Testosterone

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