Androgen receptor gene CAG repeats length in fertile and infertile Tunisian men

Hadj-Kacem, Lobna; Hadj-Kacem, Hassen; Boulila, Amel; Bahloul, Ali; Ayadi, Hammadi; Keskes, Leila

doi:10.1016/j.anngen.2004.03.010

Cited by 14 publications

(12 citation statements)

References 29 publications

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“…Data of azoospermic group were provided by 19 reports. 12–24,27,28,33,37,42,45 Six reports 13,17,25,32,61,62 provided data of oligospermic group without further stratification. Some reports 12,14–16,18-21,23,24 classify oligospermic group according to sperm concentration.…”

Section: Resultsmentioning

confidence: 99%

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Genetic Association Between Androgen Receptor Gene CAG Repeat Length Polymorphism and Male Infertility

Pan

Yao

et al. 2016

Medicine

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Section: Resultsmentioning

confidence: 99%

“…Information of the range of AR-CAG repeat length, geographic location of the study, year of publication, ethnicity of participants was also noted. In several articles, 1,13,14,17,19,25–28 we derived SD from standard error ( SE ): SD = SE × n , where n represents the size of case or control groups.…”

Section: Methodsmentioning

confidence: 99%

Genetic Association Between Androgen Receptor Gene CAG Repeat Length Polymorphism and Male Infertility

Pan

Yao

et al. 2016

Medicine

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“…The observed variations in the results from previous studies stem from several factors: 1) ethnically diverse populations; 2) the studied infertile men may represent a heterogeneous group with respect to the causes of infertility and may be under the effect of different genetic mutations or even epigenetic phenomena; and 3) different inclusion criteria in each study. The previously studied infertile populations included various categories of infertility (eg, patients with varicocele, genital tract obstruction, and/or genital tract infection) and semen parameters (azoospermia, oligozoospermia, severe oligozoospermia, or infertile men with normal sperm count associated with varying degrees of asthenozoospermia/teratozoospermia; Kukuvitis et al, 2002; Asatiani et al, 2003; Hadjkacem et al, 2004). Most importantly, the control groups in many of these previous studies were not well matched in terms of ethnicity and age.…”

Section: Discussionmentioning

confidence: 99%

Length of Androgen Receptor—CAG Repeats in Fertile and Infertile Egyptian Men

Badran

Fahmy

Abdel-Megid

et al. 2009

Journal of Andrology

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Androgens play key roles in spermatogenesis, and they exert their effect via the androgen receptor (AR). The AR gene has a repetitive DNA sequence in exon 1 that encodes a polyglutamine tract. Instability in the glutamine (CAG) repeat unit length is polymorphic across ethnic groups. Previous studies of the relationship between the repeat unit length and male infertility have been contradictory. To establish the range of wild-type alleles in Egyptian men, we determined the range of repeat lengths in a population of normally fertile, ethnically selected Egyptian men. We also investigated the association between trinucleotide repeat length within the AR gene and male factor infertility in a population of ethnically selected Egyptian infertile men, who were compared with fertile, ethnic group-matched and age-matched controls. The study included 129 clinically selected infertile Egyptian men who were scheduled for intracytoplasmic sperm injection and 52 ethnically matched fertile controls. The experimental population was grouped according to sperm counts ranging from nonobstructive azoospermia to normozoospermia. The CAG repeat N-terminal domain region of the AR gene was amplified in peripheral blood DNA, and allele size was determined by fragment analysis. Allele size and single-nucleotide polymorphism and mutation rates were determined by sequencing individual amplified alleles. The mean CAG repeat length in the azoospermia group was 18.55 6 2.0; in the severe oligozoospermia group it was 18.21 6 3.42; in the oligozoospermia group it was 18.27 6 2.93; and in the infertile with normal sperm count group it was 17.72 6 2.0. In the control group, the mean CAG repeat length was 18.18 6 3.63. No significant correlation was found between CAG repeat length and the risk of male factor infertility in an ethnically defined population of Egyptian men. However, a significant and positive correlation between CAG repeat length and serum testosterone concentration was demonstrated. This suggests the involvement of epigenetic regulation linked to this region.

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“…CAG and GGC allele length variation has been described in populations (Kittles et al 2001;Sasaki et al 2003b) of the main ethnic groups (African, American of African descent, Asian and European) but, until now, information about CAG and GGC allele distribution in Mediterranean countries has been practically non-existent (Hadjkacem et al 2004). For both STRs, remarkable allele size differences have been observed between African and non-African populations.…”

Section: Introductionmentioning

confidence: 99%