Androgen receptor expression is a significant prognostic factor in estrogen receptor positive breast cancers

Castellano, Isabella; Allìa, Elena; Accortanzo, Valeria; Vandone, A; Chiusa, Luigi; Arisio, Riccardo; Durando, Antonio; Donadio, Michela; Bussolati, Gianni; Coates, Alan S.; Viale, Giuseppe; Sapino, Anna

doi:10.1007/s10549-010-0761-y

Cited by 180 publications

(189 citation statements)

References 27 publications

(41 reference statements)

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“…These studies indicate that the frequency of AR positivity differs between different breast cancer subtypes; the highest positivity observed in ER-positive tumors in up to 80%-90% (6)(7)(8)(9)(10) and the lowest in triple-negative (TN) tumours, in up to 30% (6,7,11). Of note, a phase II trial assessing enzalutamide in metastatic TNBC, reported AR positivity (defined as !1%) in 79% of 404 cases analyzed (12).…”

Section: Introductionmentioning

confidence: 96%

“…Of note, a phase II trial assessing enzalutamide in metastatic TNBC, reported AR positivity (defined as !1%) in 79% of 404 cases analyzed (12). Retrospective clinical studies showed that AR by IHC adds prognostic information beyond the established clinicopathologic parameters in all patient groups and in patients with early-stage ER-positive breast cancer (9,13,14). Tumors coexpressing AR and ER are smaller, have lower Nottingham grade and low proliferative index (14), lymph node involvement is less frequent, and they are more likely to be found in postmenopausal women (4).…”

Section: Introductionmentioning

confidence: 99%

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The Prognostic Role of Androgen Receptor in Patients with Early-Stage Breast Cancer: A Meta-analysis of Clinical and Gene Expression Data

Božović-Spasojević

Zardavas

Brohée

et al. 2017

Clinical Cancer Research

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Purpose: Androgen receptor (AR) expression has been observed in about 70% of patients with breast cancer, but its prognostic role remains uncertain.Experimental Design: To assess the prognostic role of AR expression in early-stage breast cancer, we performed a metaanalysis of studies that evaluated the impact of AR at the protein and gene expression level on disease-free survival (DFS) and/or overall survival (OS). Eligible studies were identified by systematic review of electronic databases using the MeSH-terms "breast neoplasm" and "androgen receptor" and were selected after a qualitative assessment based on the REMARK criteria. A pooled gene expression analysis of 35 publicly available microarray data sets was also performed from patients with early-stage breast cancer with available gene expression and clinical outcome data.Results: Twenty-two of 33 eligible studies for the clinical meta-analysis, including 10,004 patients, were considered as evaluable for the current study after the qualitative assessment. AR positivity defined by IHC was associated with improved DFS in all patients with breast cancer [multivariate (M) analysis, HR 0.46; 95% confidence interval (CI) 0.37-0.58, P < 0.001] and better OS [M-HR 0.53; 95% CI, 0.38-0.73, P < 0.001]. Thirty-five datasets including 7,220 patients were eligible for the pooled gene expression analysis. High AR mRNA levels were found to confer positive prognosis overall in terms of DFS (HR 0.82; 95% CI 0.72-0.92;P ¼ 0.0007) and OS (HR 0.84; 95% CI, 0.75-0.94; P ¼ 0.02) only in univariate analysis.Conclusions: Our analysis, conducted among more than 17,000 women with early-stage breast cancer included in clinical and gene expression analysis, demonstrates that AR positivity is associated with favorable clinical outcome. Clin Cancer Res; 23(11); 2702-12. Ó2016 AACR.

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Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

The Prognostic Role of Androgen Receptor in Patients with Early-Stage Breast Cancer: A Meta-analysis of Clinical and Gene Expression Data

Božović-Spasojević

Zardavas

Brohée

et al. 2017

Clinical Cancer Research

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“…Immunohistochemical (IHC) expression of AR is reported in 70% to 90% of all invasive breast cancers (4,5). Several studies have indicated that AR is an independent positive prognostic marker in breast cancer, as well as a predictive factor for response to endocrine treatment (4,(6)(7)(8)(9)(10). AR has frequently been co-expressed with the estrogen receptor alpha (ER) and the progesterone receptor (PR) (8,11,12).…”

Section: Introductionmentioning

confidence: 99%

Age at first childbirth and oral contraceptive use are associated with risk of androgen receptor-negative breast cancer: the Malmö Diet and Cancer Cohort

Elebro

Butt

Dorkhan

et al. 2014

Cancer Causes Control

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Link to publication Citation for published version (APA): Elebro, K., Butt, S., Dorkhan, M., Jernström, H., & Borgquist, S. (2014). Age at first childbirth and oral contraceptive use are associated with risk of androgen receptor-negative breast cancer: the Malmö Diet and Cancer Cohort. Cancer Causes and Control, 25(8), 945-957. DOI: 10.1007/s10552-014-0394-2 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal

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“…рассма-тривали 2 подтипа РМЖ: люминальный В HER + и лю-минальный В HER -в зависимости от экспрессии AR. Авторы пришли к выводу, что в группе больных лю-минальным В HER + РМЖ с экспрессией AR прогноз более благоприятный, чем в группе без экспрессии AR, а у пациентов с люминальным В HER -подтипом достоверной разницы не было [23]. M. C. Hodgson и со-авт.…”

Section: опухоли женской репродуктивной системы Tumors Of Female Reprunclassified

Immunological and molecular genetic characteristics of luminal B breast cancer: a literature review

Рябчиков¹,

Воротников²,

Titov³

et al. 2016

Tumors of female reproductive system

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Androgen receptor expression is a significant prognostic factor in estrogen receptor positive breast cancers

Cited by 180 publications

References 27 publications

The Prognostic Role of Androgen Receptor in Patients with Early-Stage Breast Cancer: A Meta-analysis of Clinical and Gene Expression Data

The Prognostic Role of Androgen Receptor in Patients with Early-Stage Breast Cancer: A Meta-analysis of Clinical and Gene Expression Data

Age at first childbirth and oral contraceptive use are associated with risk of androgen receptor-negative breast cancer: the Malmö Diet and Cancer Cohort

Immunological and molecular genetic characteristics of luminal B breast cancer: a literature review

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