Androgen metabolism in the baboon: A comparison with the human

Yamamoto, Yukio; Manyon, A.; Osawa, Yosuke; Kirdani, Rashad Y.; Sandberg, A.A.

doi:10.1016/0022-4731(78)90195-4

Cited by 6 publications

(2 citation statements)

References 22 publications

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“…28 However, to our knowledge, the distribution and ontogenetic changes in b-ARs during fetal life has not been described in any primate species. As there is a high degree of evolutionary conservation between proteins in baboons and humans as well as the similarities between the 2 species in ontogeny, reproductive physiology, placentation, and maternal-fetal transfer, 16,29,30 we conducted the present study to investigate the distribution and ontogenetic changes in b-ARs in fetal baboon liver in the normative and MNR situation. In the present study, we have demonstrated the presence of both b 1 -and b 2 -ARs but not b 3 -ARs (data not shown) in the fetal baboon liver.…”

Section: Discussionmentioning

confidence: 99%

Moderate Global Reduction in Maternal Nutrition Has Differential Stage of Gestation Specific Effects on β1- and β2-Adrenergic Receptors in the Fetal Baboon Liver

et al. 2011

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Hepatic b-adrenergic receptors (b-ARs) play a pivotal role in mobilization of reserves via gluconeogenesis and glycogenolysis to supply the animal with its energy needs during decreased nutrient availability. Using a unique nutrient-deprived baboon model, we have demonstrated for the first time that immunoreactive hepatic b 1 -and b 2 -AR subtypes are regionally distributed and localized on cells around the central lobular vein in 0.5 and 0.9 gestation (G) fetuses of ad libitum fed control (CTR) and maternal nutrient restricted (MNR) mothers. Furthermore, MNR decreased fetal liver immunoreactive b 1 -AR and increased immunoreactive b 2 -AR at 0.5G. However, at 0.9G, immunohistochemistry and Western blot analysis revealed a decrease in b 1 -AR and no change in b 2 -AR levels. Thus, MNR in a nonhuman primate species has effects on hepatic b 1 -and b 2 -ARs that are receptor-and gestation stage-specific and may represent compensatory systems whose effects would increase glucose availability in the presence of nutrient deprivation.

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Section: Discussionmentioning

confidence: 99%

Moderate Global Reduction in Maternal Nutrition Has Differential Stage of Gestation Specific Effects on β1- and β2-Adrenergic Receptors in the Fetal Baboon Liver

et al. 2011

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“…We are interested in utilizing the baboon as a nonhuman primate model for assessing the safety and immunogenicity of candidate vaccines in adults, pregnant females, and their infants, both full-term and premature. Our basis for selecting the baboon is because of similarities to humans in ontogeny, immunology (four IgG subclasses), reproductive physiology, placentation, and maternal-fetal transfer (4,5,8,9,15,21,22,24). The advantages of the baboon over other commonly used, simian primates include the ease of timed pregnancies due to the estrogen-sensitive sex skin in cycling females, the comparative availability because baboons breed year round, the lack of susceptibility to herpes B virus, the relative ease of handling, and lower associated costs.…”

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confidence: 99%

The baboon as a nonhuman primate model for assessing the effects of maternal immunization with Haemophilus influenzae type b polysaccharide vaccines

et al. 1997

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These studies were performed to assess the utility of the baboon as a nonhuman primate model to evaluate vaccines for use in humans. Specifically, we examined the antibody response of baboons immunized during the third trimester of pregnancy with Haemophilus influenzae type b (Hib) polyribosylribitol phosphate (PRP) conjugate and unconjugated polysaccharide vaccines. Some of the vaccinated mothers failed to respond to a single immunization with unconjugated Hib PRP. Specific Hib PRP immunoglobulin G (IgG) but not IgM antibodies cross the baboon placenta and are detected in the offspring. Higher-titer baboon anti-Hib PRP did not express two previously defined cross-reactive human anti-Hib PRP idiotypes and was biased towards light-chain expression. Spectrotype analysis indicated that baboon anti-Hib PRP was restricted in heterogeneity and oligoclonal.

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