Androgen levels of preeclamptic patients in the third trimester of pregnancy and six weeks after delivery

Serin, İbrahim Serdar; Kula, Mustafa; Başbuğ, Mustafa; Unluhizarci, K.; Güçer, Şükran; Tayyar, Mehmet

doi:10.1034/j.1600-0412.2001.801107.x

Cited by 66 publications

(22 citation statements)

References 23 publications

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“…Although it was found to be within normal range, the level of total testosterone in women with previous SGA infants was significantly higher than those of controls ( P = 0.01). This result is consistent with the evidence of augmented androgen levels during and after pregnancy in women with preeclampsia and gestational hypertension 35,36 . However, the lack of independent association with FMD seems to suggest that testosterone cannot be considered a significant cardiovascular risk factor in these women.…”

Section: Discussionsupporting

confidence: 89%

Cardiovascular risk factors in healthy women with previous small for gestational age infants

Paradisi¹,

Mattoli

Tomei³

et al. 2011

J of Obstet and Gynaecol

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Section: Discussionsupporting

confidence: 89%

Cardiovascular risk factors in healthy women with previous small for gestational age infants

Paradisi¹,

Mattoli

Tomei³

et al. 2011

J of Obstet and Gynaecol

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“…Several authors [15,16] reported high androgen levels in women with pre-eclampsia. In fact, androgens could mediate hemodynamic changes underlying pre-eclampsia development by inducing a state of sympathetic hyperactivity and vascular hyperactivity [20].…”

Section: Discussionmentioning

confidence: 99%

Changes in androgens and insulin sensitivity indexes throughout pregnancy in women with polycystic ovary syndrome (PCOS): relationships with adverse outcomes

et al. 2010

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BackgroundGiven the high rate of pregnancy and perinatal complications recently observed in patients with polycystic ovary syndrome (PCOS) and the lack of data on the serum variations in androgens and insulin sensitivity indexes in pregnant women with PCOS, the current study was aimed to assess these changes and their potential effect on pregnancy outcomes in a population of women with PCOS.MethodsForty-five pregnant patients with ovulatory PCOS (PCOS group) and other 42 healthy pregnant women (control group) were studied assaying serum androgen levels and insulin sensitivity indexes throughout pregnancy serially, and recording obstetrical outcomes.ResultsSerum androgen levels and insulin resistance indexes were significantly (p < 0.05) higher in PCOS than in control group at study entry, these differences were sustained throughout pregnancy, and their changes resulted significantly (p < 0.05) different between PCOS and control group. In PCOS patients, women who had a complicated pregnancy showed serum androgen levels and insulin sensitivity indexes significantly (p < 0.05) worse in comparison to subjects without any pregnancy and/or neonatal complications.ConclusionsPCOS patients have impaired changes in serum androgen levels and insulin sensitivity indexes during pregnancy. These alterations could be implicated in the pregnancy and neonatal complications frequently observed in women affected by PCOS.

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“…For this study, we elected to use this dosing regimen, since it caused a 2-fold increase in circulating maternal testosterone levels [17] similar to that observed in human pregnancies complicated with fetal growth inhibition [6-10]. Because an increase in testosterone levels during the later stage of pregnancy was shown to be associated with IUGR [5] and preeclampsia [31,32], we chose this time period (GD 15-19) of TP treatment in pregnant rats.…”

Section: Methodsmentioning

confidence: 99%

Prenatal testosterone-induced fetal growth restriction is associated with down-regulation of rat placental amino acid transport

Sathishkumar

Elkins

Chinnathambi

et al. 2011

Reprod Biol Endocrinol

107

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BackgroundExposure of pregnant mothers to elevated concentrations of circulating testosterone levels is associated with fetal growth restriction and delivery of small-for-gestational-age babies. We examined whether maternal testosterone crosses the placenta to directly suppress fetal growth or if it modifies placental function to reduce the capacity for transport of nutrients to the fetus.MethodsPregnant rats were exposed to testosterone propionate (TP; 0.5 mg/kg) by daily subcutaneous injection from gestational days (GD) 15-19. Maternal and fetal testosterone levels, placental nutrient transport activity and expression of transporters and birth weight of pups and their anogenital distances were determined.ResultsThis dose of TP doubled maternal testosterone levels but had no effect on fetal testosterone levels. Maternal daily weight gain was significantly lower only on GD 19 in TP treated dams compared to controls. Placental weight and birth weight of pups were significantly reduced, but the anogenital distance of pups were unaffected by TP treatment. Maternal plasma amino acids concentrations were altered following testosterone exposure, with decreases in glutamine, glycine, tyrosine, serine, proline, and hydroxyproline and increases in asparagine, isoleucine, leucine, lysine, histidine and arginine. In the TP dams, placental system A amino acid transport activity was significantly reduced while placental glucose transport capacity was unaffected. Decreased expression of mRNA and protein levels of slc38a2/Snat2, an amino acid transporter, suggests that reduced transporter proteins may be responsible for the decrease in amino acid transport activity.ConclusionsTaken together, these data suggest that increased maternal testosterone concentrations do not cross the placenta to directly suppress fetal growth but affects amino acid nutrient delivery to the fetus by downregulating specific amino acid transporter activity.

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Androgen levels of preeclamptic patients in the third trimester of pregnancy and six weeks after delivery

Abstract: We conclude that higher blood androgen levels measured in preeclamptic patients may be implicated in the pathogenesis of preeclampsia.

Cited by 66 publications

References 23 publications

Cardiovascular risk factors in healthy women with previous small for gestational age infants

Cardiovascular risk factors in healthy women with previous small for gestational age infants

Changes in androgens and insulin sensitivity indexes throughout pregnancy in women with polycystic ovary syndrome (PCOS): relationships with adverse outcomes

Prenatal testosterone-induced fetal growth restriction is associated with down-regulation of rat placental amino acid transport

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