Androgen levels of preeclamptic patients in the third trimester of pregnancy and six weeks after delivery

Serin, İbrahim Serdar; Kula, Mustafa; Başbuğ, Mustafa; Unluhizarci, K.; Güçer, Şükran; Tayyar, Mehmet

doi:10.1080/obs.80.11.1009.1013

Cited by 24 publications

(45 citation statements)

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“…Confirming the results of Acromite et al and Serin et al [12,13], we found that serum concentrations of T are increased in patients with PIH compared to healthy pregnant controls. Beside an increased serum level of T, serum concentrations of AN have also significantly elevated in our series of women with PIH.…”

Section: Discussionsupporting

confidence: 95%

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Elevated serum concentrations of androgens in women with pregnancy-induced hypertension

Jirecek

Joura

Tempfer

et al. 2003

Wien Klin Wochenschr

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Alterations of steroid hormone profiles have been suggested to be involved in the pathophysiology of pregnancy-induced hypertension (PIH). The aim of our study was first to investigate serum concentrations of testosterone, dihydrotestosterone, androstenedione and dehydroepiandrostenedione sulfate in women with PIH and normotensive pregnant women and secondly to evaluate an association between elevated serum concentrations of androgens and the development of severe disease. Serum concentrations of androgens were measured in 40 patients with PIH and 40 normotensive pregnant women, matched for gestational age, determined by enzyme linked immunosorbent assay. Multivariate logistic regression models were used to analyze the influence of elevated serum concentrations of androgens on the occurrence of PIH and the development of severe disease. The median serum concentrations of androstenedione and testosterone were significantly elevated in women with PIH compared to controls (6.3 and 5.0 ng/ml, 1.8 and 1.1 ng/ml, p = 0.005 and p = 0.04, respectively). The difference between the median serum concentrations of dihydrotestosterone and dehydroepiandrostenedione sulfate in women with PIH and controls was not significant. Elevated serum concentrations of androstenedione revealed a significant influence on the odds of presenting with PIH (p = 0.043) and were significantly associated with the development of severe disease (p = 0.014). Women with PIH have elevated serum concentrations of androstenedione and testosterone. Moreover, elevated serum concentrations of androstenedione are associated with development of severe disease.

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Section: Discussionsupporting

confidence: 95%

“…In accordance with this finding, other reports [12,13] indicated increased serum concentrations of testosterone in patients with preeclampsia.…”

Section: Discussionsupporting

confidence: 92%

Elevated serum concentrations of androgens in women with pregnancy-induced hypertension

Jirecek

Joura

Tempfer

et al. 2003

Wien Klin Wochenschr

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“…In that paper, I hypothesised that the high levels of maternal androgens that are thought to be partially responsible for the fetal sex (see James 2008) also cause the pathology at a later stage of pregnancy. Confi rmatory evidence has been published in the form of reports of higher androgens in pre-eclamptic women in the 2nd trimester (Carlsen et al 2005), the 3rd trimester (Serin et al 2001) and at term (Troisi et al 2003). Also consistent with this hypothesising, is the report that male fetuses were associated with chronic infl ammatory lesions of the placenta (Ghidini and Salafi a 2005).…”

Section: W H Jamessupporting

confidence: 69%

Change in paternity, pre-eclampsia, fetal growth retardation and maternal testosterone concentration

2013

Journal of Obstetrics and Gynaecology

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“…Total and free testosterone levels are elevated in preeclamptic women in the third trimester of pregnancy compared with normotensive controls (40). These elevated testosterone levels could be responsible for enhanced renal inflammation and endothelial and tubular cell injury that might lead to toxemia.…”

Section: Gender Differences On Renal Function and Morphology Aftermentioning

confidence: 99%

Testosterone Is Responsible for Enhanced Susceptibility of Males to Ischemic Renal Injury

Park

Kim

Ahn

et al. 2004

Journal of Biological Chemistry

299

273

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Female mice are much more resistant to ischemia/ reperfusion (I/R)-induced kidney injury when compared with males. Although estrogen administration can partially reduce kidney injury associated with I/R, we demonstrated that the presence of testosterone, more than the absence of estrogen, plays a critical role in gender differences in susceptibility of the kidney to ischemic injury. Testosterone administration to females increases kidney susceptibility to ischemia. Dihydrotestosterone, which can not be aromatized to estrogen, has effects equal to those of testosterone. Castration reduces the I/R-induced kidney injury. In contrast, ovariectomy does not affect kidney injury induced by ischemia in females. Testosterone reduces ischemia-induced activation of nitric oxide synthases (NOSs) and Akt and the ratio of extracellular signal related kinase (ERK) to c-jun N-terminal kinase (JNK) phosphorylation. Pharmacological (N -nitro-L-arginine) or genetic (endothelial NOS or inducible NOS) inhibition of NOSs in females enhances kidney susceptibility to ischemia. Nitric oxide increases Akt phosphorylation and protects MadinDarby canine kidney epithelial cells from oxidant stress. Antagonists of androgen or estrogen receptors do not affect the gender differences. In conclusion, testosterone inhibits the post-ischemic activation of NOSs and Akt and the ratio of ERK to JNK phosphorylation through non-androgen receptor-medicated mechanisms, leading to increased inflammation and increased functional injury to the kidney. These findings provide a new paradigm for the design of therapies for ischemia/ reperfusion injury and may be important to our understanding of the pathophysiology of acute renal failure in pregnancy where plasma androgen levels are elevated.

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Androgen levels of preeclamptic patients in the third trimester of pregnancy and six weeks after delivery

Cited by 24 publications

References 0 publications

Elevated serum concentrations of androgens in women with pregnancy-induced hypertension

Elevated serum concentrations of androgens in women with pregnancy-induced hypertension

Change in paternity, pre-eclampsia, fetal growth retardation and maternal testosterone concentration

Testosterone Is Responsible for Enhanced Susceptibility of Males to Ischemic Renal Injury

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