Androgen Levels in Men with Diabetes Mellitus

Semple, C. G.; Gray, C. E.; Beastall, G. H.

doi:10.1111/j.1464-5491.1988.tb00957.x

Cited by 19 publications

(10 citation statements)

References 15 publications

(3 reference statements)

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“…Therefore, in their management, apart from looking at other confounding factors including obesity, diabetes, and aging (Semple et al, 1988;Giagulli et al, 1994;Gooran, 1996;Wändell and Brorsson, 2000), the sleep history of men must be explored as a possible contributing factor for their low androgen concentrations.…”

Section: Discussionmentioning

confidence: 99%

Sleep, Sex Steroid Hormones, Sexual Activities, and Aging in Asian Men

Goh

Tong

2010

Journal of Andrology

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This was a cross-sectional study to examine the different associations of age and sleep duration with sex steroid hormones and sexual activities in 531 Asian Chinese men aged between 29 and 72 years old. Sleep duration and sexual activities were evaluated through a self-administered questionnaire, and total testosterone (T), sex hormone-binding globulin (SHBG), estradiol (E2), and dehydroepiandrosterone sulfate (DHEAS) were measured by established immunoassay methods in a single blood sample collected between 8:00 and 11:00 AM. Bioavailable T (BioT) was calculated using the Vermeulen formula. Age was a major determinant of sleep, sex steroid hormones, and sexual activities in men. BioT, DHEAS, coital frequency, masturbation, and sleep duration declined with age. On the other hand, SHBG and E2 increased with age. Sleep duration, independently of age, aerobic exercise, and body fat, was positively associated with T and BioT, but not with DHEAS, E2, or any of the sexual activities studied. Men who masturbated had higher levels of both T and BioT. DHEAS was significantly associated with coital frequency and desire for sex. The present study showed that besides age, sleep duration was associated with androgen concentrations in men, and thus the evaluation of sleep hygiene may be beneficial in the management of men with low androgen concentrations. DHEAS may be independently associated with some sexual functions in men.

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Section: Discussionmentioning

confidence: 99%

Sleep, Sex Steroid Hormones, Sexual Activities, and Aging in Asian Men

Goh

Tong

2010

Journal of Andrology

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“…There are several reports, however, referring to psychogenic disturbances and organic disorders as the cause [17,18]. From an endocrinological point of view, there are reports that serum testosterone levels are lower in cases of diabetes associated with sexual dysfunction than in controls [19,20]. Sex hormone-binding protein has the effect of controlling the action of testosterone, and acts as an amplifier of estrogenic action.…”

Section: Discussionmentioning

confidence: 99%

Gonadal Hormones and Gonadal Function in Type 2 Diabetes Model OLETF (Otsuka Long Evans Tokushima Fatty) Rats

2005

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Abstract. Gonadal functions, with special reference to blood levels of sex-related markers such as 17b-estradiol (E2), free testosterone (free Te) and lutenizing hormone (LH), were examined in male OLETF (Otsuka Long Evans Tokushima Fatty) diabetic rats, a model of human type 2 diabetes mellitus. Male rats of the OLETF strain and male rats of the LETO strain, which act as a control of OLETF, both supplied by Otsuka Pharmaceutical Co., Ltd. (Tokushima, Japan), were periodically examined for blood levels of E2, free Te and LH at the age of 4, 5, 32, 40 and 64 weeks. The weight of the testis, the number of sperm contained within and histological findings of the testis were comparatively studied in both strains. Glucose and insulin (IRI) at fasting were examined to evaluate the homeostasis model assessment (HOMA) index. In order to investigate any sex hormone imbalance, sex hormone-binding globulin (SHBG) was measured by a dextrancharcoal assay. All of the OLETF rats became diabetic at the age of 32 weeks. There were no significant differences between OLETF and LETO rats regarding free Te, E2, LH or SHBG during the observation period from 4 to 64 weeks. Testis weight was significantly decreased in OLETF rats at 32 and 64 weeks and sperm counts at 64 weeks of age were also significantly decreased. Histologically, there was seminiferous tubule atrophy in the OLETF rats at 64 weeks of age. A significant negative correlation between testis weight and fasting blood glucose, as well as HOMA index, was observed in OLETF rats. In male diabetic OLETF rats, with a variety of hypogonadisms such as atrophy of the testis and low sperm count, the serum levels of E2, free Te, LH and SHBG were normally preserved. [5,6]. From about 20 weeks of age, OLETF rats begin to develop diabetes accompanied by obesity, and almost all of the rats develop diabetes by the age of 30 weeks. This study was intended to make clear, whether sexual dysfunctions, if any, occur in diabetic OLETF rats by examining serum levels of sex-related hormones and sex hormone-binding globulin (SHBG), as well as testis findings. SHBG is a factor affecting sex hormone activities by binding both testosterone and 17b-estradiol (E2), with a higher affinity for the former [7,8]. Materials and Methods AnimalsBoth OLETF rats and their controls, named LETO (Long-Evans Tokushima Otsuka) rats, which are nondiabetic, were supplied by Otsuka Pharmaceutical Co., Ltd. (Tokushima, Japan). OLETF rats comprising 4, 5, 32, 40 and 64 weeks of age and control LETO rats corresponding to each OLETF age were studied. After

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“…1). While the HPT axis is the central endocrine mechanism governing reproductive function, it does not exclude the involvement of other hormonal fac-tors such as cortisol (Schaison et al, 1978), insulin (Semple et al, 1988), leptin (Garcia-Mayor et al, 1997), and thyroid hormone (Gordon et al, 1969), as well as a variety of other substances. Nonetheless, the HPT axis is the central endocrine-regulating feature of male reproductive function and will be the focus here.…”

Section: Reproductive Endocrinologymentioning

confidence: 99%

Reproductive ecology and life history of the human male

Bribiescas

2001

Am. J. Phys. Anthropol.

210

117

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Until recently, the reproductive ecology of human males has not been extensively investigated, primarily as a result of the need for a theoretical framework based on the reproductive constraints and energetics of mammalian males. More specifically, male reproductive ecology has necessitated an integrative interpretation of clinical and anthropological data based on the premise that the evolution of human male life histories has involved selection for physiological mechanisms aimed at optimizing trade-offs between survivorship and reproductive effort. This paper attempts to address this gap in our understanding by presenting the current state of male reproductive ecology, including physiologic data from clinical and anthropological investigations as well as recent theoretical developments. Recent investigations outlining population variation in reproductive endocrine function are discussed within the context of potential sources of variation, including energetic expediture, caloric intake, and developmental canalization during adolescence. Additional summaries of male senescence and behavior are presented to provide a complete overview of male life history. Implications of recent anthropological data on contemporary health issues such as prostate cancer and the development of a male contraceptive are also discussed. Finally, several theories are presented that may contribute to our understanding of the evolution of male life histories and reproductive ecology, including theoretical suggestions involving the role of competition, mate choosiness, and potential constraints on male insemination ability, as well as a theory suggesting that male reproductive ecology may be best understood by analyzing energetic allocation decisions between differing somatic tissues that may be indicative of the competing needs for optimizing survivorship and reproductive effort. Directions for future research are finally considered.

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Androgen Levels in Men with Diabetes Mellitus

Cited by 19 publications

References 15 publications

Sleep, Sex Steroid Hormones, Sexual Activities, and Aging in Asian Men

Sleep, Sex Steroid Hormones, Sexual Activities, and Aging in Asian Men

Gonadal Hormones and Gonadal Function in Type 2 Diabetes Model OLETF (Otsuka Long Evans Tokushima Fatty) Rats

Reproductive ecology and life history of the human male

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