Androgen-deprivation therapy impairs left ventricle functions in prostate cancer patients

Subclinical left ventricular dysfunction in men under androgen deprivation therapy for prostate cancer, revealed by speckle‐tracking‐derived parameters, repolarization, and myocardial injury markers

“…9 Our results are in agreement with other data in the literature. Kanar BG et al 22 studied 49 patients 71.5 ± 6.7 years old with prostate cancer, treated with radiotherapy and ADT versus 32 patients, 71.9 ± 7 years old treated with prostatectomy alone and described the reduction in GLS, GCS, and radial strain after 6 months of treatment only in patients who received ADT. Post HK et al 23 demonstrated in 3 patients 66 ± 7 years old with prostate cancer receiving ADT that GLS decreased from the resting value during exercise, compared to 4 age-matched healthy subjects in whom GLS increased during exercise.…”

Cardiac Mechanics in Altered Hormonal States as a Surrogate for Understanding the Effects of Transgender Hormone Therapy

“…In a study of 49 patients with PCA treated with ADT and radiation therapy, in comparison to 42 healthy control subjects and 32 PCA patients undergoing prostatectomy alone, the authors did not find any significant differences in conventional echocardiographic parameters [eg, left ventricular ejection fraction (LVEF), E/A, or E/e′ ratios] at baseline or at 6 months follow-up. 14 However the investigators did find that echocardiographic measures of strain (eg, global longitudinal strain, global circumferential strain, and global radial strain) in the patients taking ADT were significantly impaired after 6 months. 14 Similarly, a prospective observational study of 31 men with PCA undergoing ADT for 6 months found impaired GLS, in the absence of differences in conventional echocardiographic measurements.…”

“…14 However the investigators did find that echocardiographic measures of strain (eg, global longitudinal strain, global circumferential strain, and global radial strain) in the patients taking ADT were significantly impaired after 6 months. 14 Similarly, a prospective observational study of 31 men with PCA undergoing ADT for 6 months found impaired GLS, in the absence of differences in conventional echocardiographic measurements. 15 While it is difficult to interpret these “subclinical” changes in echocardiographic strain, clinical insight may be obtained from a larger cohort study that did not feature echocardiography.…”

Testosterone, cardiomyopathies, and heart failure

“…In addition to increasing the risk of myocardial infarction (MI) and coronary heart disease (CHD), androgen deprivation therapy is also associated with a decrease in left ventricular longitudinal, circumferential, and radial strain measures, as assessed by speckle-tracking echocardiography. 27 …”