Androgen-dependent immune modulation in parasitic infection

Sellau, Julie; Groneberg, Marie; Lotter, Hannelore

doi:10.1007/s00281-018-0722-9

Cited by 18 publications

(19 citation statements)

References 114 publications

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Section: Mechanisms Of Androgen Sex Steroid Actionmentioning

confidence: 99%

“…Because androgens are lipophilic steroid hormones, they can easily diffuse across cell membranes without the need for receptor-mediated import ( 8 ). Androgens in circulation are found mostly bound to sex hormone-binding globulin and albumin ( 8 ). Free (unbound) steroid sex hormones can signal through two different mechanisms: the classical AR, located in the intracellular compartment, and the membrane, or non-classical, AR ( 8 ).…”

Section: Mechanisms Of Androgen Sex Steroid Actionmentioning

confidence: 99%

“…Androgens in circulation are found mostly bound to sex hormone-binding globulin and albumin ( 8 ). Free (unbound) steroid sex hormones can signal through two different mechanisms: the classical AR, located in the intracellular compartment, and the membrane, or non-classical, AR ( 8 ). Androgen binding to classical and non-classical ARs mediates genomic and non-genomic androgen effects, respectively ( 177 ).…”

Section: Mechanisms Of Androgen Sex Steroid Actionmentioning

confidence: 99%

“…Most studies of androgen–AR complex-mediated gene expression have been carried out in the context of male reproductive tissue in prostate cancer (PCa) ( 183 – 185 ). As previously discussed, immune cells are responsive to sex hormones, and almost all immune cells express sex hormone receptors ( 8 ). Mouse monocytes, macrophages ( 186 ), and DCs ( 187 ) express both classical and non-classical ARs although the vast majority studies do not specifically dissect the role of the two types of AR on the outcomes being measured in the study.…”

Section: Mechanisms Of Androgen Sex Steroid Actionmentioning

confidence: 99%

“…Because the concentration of sex hormones changes over the lifespan and throughout the course of the menstrual cycle in women, the function of the immune system also changes during different stages of life. Innate myeloid immune cells, like other cell types, express sex hormone receptors and are responsive to sex hormones (8).…”

Section: Introductionmentioning

confidence: 99%

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Androgen and Androgen Receptors as Regulators of Monocyte and Macrophage Biology in the Healthy and Diseased Lung

2020

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Androgens, the predominant male sex hormones, drive the development and maintenance of male characteristics by binding to androgen receptor (AR). As androgens are systemically distributed throughout the whole organism, they affect many tissues and cell types in addition to those in male sexual organs. It is now clear that the immune system is a target of androgen action. In the lungs, many immune cells express ARs and are responsive to androgens. In this review, we describe the effects of androgens and ARs on lung myeloid immune cells-monocytes and macrophages-as they relate to health and disease. In particular, we highlight the effect of androgens on lung diseases, such as asthma, chronic obstructive pulmonary disease and lung fibrosis. We also discuss the therapeutic use of androgens and how circulating androgens correlate with lung disease. In addition to human studies, we also discuss how mouse models have helped to uncover the effect of androgens on monocytes and macrophages in lung disease. Although the role of estrogen and other female hormones has been broadly analyzed in the literature, we focus on the new perspectives of androgens as modulators of the immune system that target myeloid cells during lung inflammation.

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Section: Mechanisms Of Androgen Sex Steroid Actionmentioning

confidence: 99%