Androgen Control of the Sexual Maturation Pheromone in House Mouse Urine1

Lombardi,; Jg, Vandenbergh; Jm, Whitsett

doi:10.1095/biolreprod15.2.179

Cited by 70 publications

(26 citation statements)

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“…Castrated male field voles had no effect on the sexual development of the young females, as has been found for the laboratory and house mouse (Colby & Vandenbergh, 1974;Bronson & Maruniak, 1975). Castrated male mice regain their ability to accelerate puberty when testosterone propionate is administered, indicating that the inability of castrated males to stimulate female maturation is probably due to the absence of a male hormone-dependent pheromone (Lombardi, Vandenbergh &Whitsett, 1976).…”

Section: Introductionsupporting

confidence: 55%

Effect of male presence and of photoperiod on the sexual maturation of the field vole (Microtus agrestis)

Spears¹,

Clarke²

1986

Reproduction

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Summary. The effect of mature males on the sexual development of young female and male field voles, reared in either long (stimulating) or short (inhibiting) photoperiods, was examined. Females reared in the presence of a mature male had a more advanced state of sexual maturation (as indicated by uterine weight) than did females reared in isolation from males, in long and short photoperiods (P < 0\m=.\01). No interaction between photoperiod and male presence was found. Augmented uterine growth occurred not only when young females were separated from mature males by a wire mesh or solid metal screen but also when they were merely exposed to bedding previously used by mature males. Castrated males had no effect on the sexual development of females. The effect ofmature males on the sexual development of young males was less clear, although there was some indication that the presence of adult males inhibited their sexual development in long and short photoperiods. For males and females, growth rate was stimulated by long photoperiod, but no effect of male presence on growth rate was found.

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Section: Introductionsupporting

confidence: 55%

Effect of male presence and of photoperiod on the sexual maturation of the field vole (Microtus agrestis)

Spears¹,

Clarke²

1986

Reproduction

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“…In mice these proteins, with an average molecular weight of 17 800 (Finlayson & Baumann, 1958), are probably synthesized in the liver (Finlayson, Asofsky, Potter & Runner, 1965) and are associated with a pheromonal activity (Vandenbergh, Whitsett & Lombardi, 1975;Lombardi, Vandenbergh & Whitsett, 1976). The sexual development of female mice is accelerated by exposure to these pheromones, which are either part of or bound to the protein.…”

Section: Sex-dependent Protein Excretionmentioning

confidence: 99%

Proteinuria in rats in relation to age-dependent renal changes

et al. 1980

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Wiechert-A llee 9, 3000 Hannover 6I, and 3Zentralinstitut fiir Versuchstiere, Let/ow-Vorbeck-A llee 57, 3000Hannover 91, Federal Republic of Germany 95 Summary A variety of sex-dependent urinary proteins of low molecular weight, absent in females and in castrated males, can be identified in male rats by disc electrophoresis. In the urine of male rats of age 5·5 months, albumin comprises only 1-2% of the total protein. Albumin excretion increases greatly with age and associated kidney disease. Total protein excretion, however, stays the same or even decreases slightly as the rat ages, due to a loss of low molecular weight, sex-dependent, proteins. These are virtually absent in senescent rats (38 months of age), although total protein excretion rises tenfold in these animals due to high molecular weight plasma proteins passing into the urine; the glomerular filtration rate decreases to 70% of the value measured at 5·5 months of age.

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“…Castrated males cannot induce the Bruce effect (Bruce 1965, Vella & deCatanzaro 2001 or the Vandenbergh effect (Colby & Vandenbergh 1974). Treatment with testosterone (Dominic 1965, Lombardi et al 1976 or E 2 (Thorpe & deCatanzaro 2012) restores the ability of castrated males to induce these effects. Evidence shows clear mechanisms by which E 2 can disrupt blastocyst implantation and promote growth of the juvenile reproductive tract.…”

Section: Introductionmentioning

confidence: 99%

Oestradiol transmission from males to females in the context of the Bruce and Vandenbergh effects in mice (Mus musculus)

Guzzo¹,

Jheon²,

Imtiaz³

et al. 2012

Reproduction

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Male mice actively direct their urine at nearby females, and this urine reliably contains unconjugated oestradiol (E 2 ) and other steroids. Giving inseminated females minute doses of exogenous E 2 , either systemically or intranasally, can cause failure of blastocyst implantation. Giving juvenile females minute doses of exogenous E 2 promotes measures of reproductive maturity such as uterine mass. Here we show that tritium-labelled E 2 ( 3 H-E 2 ) can be traced from injection into novel male mice to tissues of cohabiting inseminated and juvenile females. We show the presence of 3 H-E 2 in male excretions, transmission to the circulation of females and arrival in the female reproductive tract. In males, 3 H-E 2 given systemically was readily found in reproductive tissues and was especially abundant in bladder urine. In females, 3 H-E 2 was found to enter the system via both nasal and percutaneous routes, and was measurable in the uterus and other tissues. As supraoptimal E 2 levels can both interfere with blastocyst implantation in inseminated females and promote uterine growth in juvenile females, we suggest that absorption of male-excreted E 2 can account for major aspects of the Bruce and Vandenbergh effects.

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Androgen Control of the Sexual Maturation Pheromone in House Mouse Urine1

Cited by 70 publications

References 0 publications

Effect of male presence and of photoperiod on the sexual maturation of the field vole (Microtus agrestis)

Effect of male presence and of photoperiod on the sexual maturation of the field vole (Microtus agrestis)

Proteinuria in rats in relation to age-dependent renal changes

Oestradiol transmission from males to females in the context of the Bruce and Vandenbergh effects in mice (Mus musculus)

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