Androgen Binding Proteins and Androgen Levels in the Human Testis and Epididymis

Purvis, K.; Calandra, Ricardo S.; Sander, Serdar; Hansson, V.

doi:10.1111/j.1365-2605.1978.tb00624.x

Cited by 34 publications

(7 citation statements)

References 24 publications

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“…This might be due to differences in the age of the patients or in methodology. Testosterone concentrations in epididymides were in close agreement with those re- ported before [23], but again DHT epididymal levels were somewhat higher. Nevertheless, the already mentioned study and ours agree in the finding of much higher relative and absolute concentration of testosterone in testis than in epididymis [13, 231.…”

Section: Discussionsupporting

confidence: 74%

“…Present data confirm the earlier observation that demonstrates the absence of a concentration gradient of DHT lengthwise in the epididymis [23]. This contrasts with findings in the rat, where the DHT concentrations decreased in the distal epididymal segments 121.…”

Section: Discussioncontrasting

confidence: 56%

“…Testicular testosterone concentrations were in the range of other reports [ 12,18,28, 291 while measurement of DHT was somewhat higher than the one previously published [23]. This might be due to differences in the age of the patients or in methodology.…”

Section: Discussionmentioning

confidence: 40%

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Testosterone, Dihydrotestosterone, and Zinc Concentrations in Human Testis and Epididymis

Suescun

Campo

Rivarola

et al. 1981

Archives of Andrology

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Tissue testosterone, dihydrotestosterone, and zinc concentrations have been determined in testis and epididymis of 13 patients with carcinoma of the prostate, 1 patient with carcinoma of the penis, and 3 patients with carcinoma of the prostate on estrogens. The 13 patients not receiving estrogens had the following testicular levels: testosterone, of 529 t 63.1 ng/g (mean -+ SE); dihydrotestosterone, 23.7 t 2.58 ng/g; and zinc 62.2 -+ 7.6 &g. The epididymal levels were as follows: testosterone, 40.6 2 3.4 ngig; dihydrotestosterone, 20.5 2 2.36 ng/g; and zinc, 67.2 2 1 1 . 1 pg/g. Patients on estrogen therapy showed much lower androgen values in the two organs but zinc was not changed significantly. Concentrations of androgens were not significantly different in the epididymal fractions of caput, corpus, and cauda. In testis, there was a positive correlation between zinc and androgens contents, while the opposite was suggested by the data in the epididymis. Even though these patients were not normal, there was no evidence of testicular or epididymal disturbances.

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Section: Discussionsupporting

confidence: 74%

Section: Discussioncontrasting

confidence: 56%

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Testosterone, Dihydrotestosterone, and Zinc Concentrations in Human Testis and Epididymis

Suescun

Campo

Rivarola

et al. 1981

Archives of Andrology

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“…The testicular and epididymal tissue levels of steroids in the present study are consistent with those previously reported (e.g. Ruokonen et al 1972;Vihko et al 1975;McCowen et al 1979;Leinonen et al 1980;de la Torre et al 1982;Takahshi et al 1983;Purvis et al 1978;Suescun et al 1981). The present study, which has extended previous reports by measuring steroid levels in the vas deferens, as well as in the epididymis indicate that the circulating steroids are transported to these tissues accumulate and/or bind there; however, the synthesis of steroids by these organs cannot be ruled out completely.…”

Section: Discussionsupporting

confidence: 93%

Blood and tissue steroid levels and their interrelationship in men with pathological conditions of the reproductive organs

et al. 1986

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We have investigated the interrelationship of the levels of 10 steroids in peripheral venous, spermatic arterial and spermatic venous blood, and in tissue specimens from the epididymis, vas deferens and testis from 8 patients who underwent orchidectomy for pathological conditions of the reproductive organs. The steroids analyzed by radioimmunoassay were: pregnenolone (5-P), dehydroepiandrosterone (DHEA), 17-hydroxyprogesterone (17-OH-P), androstenedione (A), testosterone (T), dihydrotestosterone (DHT) and the sulpho-conjugated forms (-S) of 5-P, DHEA, T and DHT. The quantitatively major steroids in peripheral venous blood were, in order of magnitude, DHEA-S, 5-P-S, DHT-S, T-S and T. No difference was observed between the levels of any of the steroids measured in peripheral venous and spermatic arterial blood. With the exception of DHEA-S and DHT-S, the levels of all steroids in spermatic venous blood were substantially higher than in peripheral venous blood (P less than 0.001). No correlation was found between steroid levels in spermatic venous and peripheral venous blood. Steroid concentrations in tissue from the epididymis, vas deferens and testis were markedly higher than in peripheral venous blood (P less than 0.01 to P less than 0.001), except for the levels of DHEA-S which were about equal in the various blood and tissue specimens. Tissue to blood ratios varied from approximately 2.0 to 500 according to the steroid in question. The peripheral blood levels of 5-P-S, DHEA-S and DHT-S were substantially higher than respective unconjugated steroid levels (P less than 0.001); the ratios (sulpho-conjugated to unconjugated) were approximately 17, 215 and 30, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…There are few reports in the literature on measurements of testicular contents of testosterone Morse et al 1973;Ruokonen et al 1972;Purvis et al 1978;Nieschlag et al 1979;Harnmond et al 1978) and therefore, the significance and diagnostic value of this determination has not been fully established. Our mean value of 520 ?…”

Section: Discussionmentioning

confidence: 99%

Testicular Function in Varicocele

et al. 1980

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Testicular testosterone concentration serum testosterone, LH and FSH, sperm count and testicular histology were evaluated in 17 patients with varicocele. Testicular testosterone was either normal or high (mean 906 +/- 723 ng/g of tissue), and serum testosterone was within the normal range in most patients. Serum LH was elevated in half of the patients. The degree of testicular damage observed was extremely variable and correlated with sperm analysis. Testicular testosterone tended to be higher in patients with severe microscopic lesions of the testis. It is concluded that even though Leydig cell function is partially altered, this deficiency is compensated by LH stimulation and therefore, failure of spermatogenesis is not secondary to low testosterone levels.

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Androgen Binding Proteins and Androgen Levels in the Human Testis and Epididymis

Cited by 34 publications

References 24 publications

Testosterone, Dihydrotestosterone, and Zinc Concentrations in Human Testis and Epididymis

Testosterone, Dihydrotestosterone, and Zinc Concentrations in Human Testis and Epididymis

Blood and tissue steroid levels and their interrelationship in men with pathological conditions of the reproductive organs

Testicular Function in Varicocele

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