Androgen and oestrogen receptor status of the human appendix testis

Samnakay, Naeem; Cohen, R.J.; Orford, Jillian; King, P. A.; Davies, Robert J.

doi:10.1007/s00383-002-0936-7

Cited by 23 publications

(18 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous studies have shown that the testicular appendices of patients with cryptorchidism show significant alterations in the estrogen and androgen receptors (19,23). Patients with hydroceles also present alteration in the expression of androgen receptors and epithelial destruction in the testicular appendices (19).…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Structural analysis of testicular appendices in patients with cryptorchidism

et al. 2013

View full text Add to dashboard Cite

Objectives: Report the incidence and structure of testicular appendices (TAs) in patients with cryptorchidism, comparing their incidence with epididymal anomalies (EA) and patency of the vaginal process (PVP) and analyzes the structure of TAs. Material and Methods: We studied 72 testes of patients with cryptorchidism (average of 6 years), and 8 testes from patients with hydroceles (average of 9 years). We analyzed the relations among the testis, epididymis and PVP and prevalence and histology of the TAs. The appendices of 10 patients with cryptorchidism and 8 with hydrocele were dissected and embedded in paraffin and stained with Masson trichrome; Weigert and Picro-Sirius Red with polarization and immunohistochemistry analysis of the collagen type III fibers to observe collagen. The stereological analysis was done with the software Image Pro and Image J, using a grid to determine volumetric densities (Vv). Means were statistically compared using the ANOVA and unpaired T test (p < 0.05). Results: Of the 72 testes with cryptorchidism, 20 (27.77%) presented EA, 41 (56.9%) had PVP and 44 (61.1%) had TAs. Of the 44 testes with cryptorchidism and appendices, 30 (68.18%) presented PVP and 11 (25%) presented EA. There was no alteration of the epithelium in the appendices of patients in both groups. Stereological analysis documented the prevalence of ESFs (mean of 1.48%), prevalence of veins (mean of 10.11%) and decrease (p = 0.14) of SMCs in the TAs of patients with cryptorchidism (mean = 4.93%). Collagen III prevailed in the TAs of patients with cryptorchidism. Conclusion: The testicular appendices presented significant structural alteration in the patients with cryptorchidism, indicating that TAs present a structural remodeling.

show abstract

Section: Discussionmentioning

confidence: 98%

“…Patients with hydroceles also present alteration in the expression of androgen receptors and epithelial destruction in the testicular appendices (19). These alterations are argued to be associated with increased hydrostatic pressure in the scrotum of patients with hydroceles (19,23).…”

Section: Discussionmentioning

confidence: 99%

Structural analysis of testicular appendices in patients with cryptorchidism

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Recently, Samnakay et al [9] described that the human appendix testis was found to express both estrogen and androgen receptors. The significantly lower incidence of appendix testis in patients with undescended testes versus those with descended testes may suggest a physiological role of appendix testis, regulated by sexual steroids, in the process of testicular migration.…”

Section: Discussionmentioning

confidence: 99%

Decreased Incidence of Appendix Testis in Cryptorchidism with Intraoperative Survey

Józsa

Csízy²,

Kutasy³

et al. 2008

Urol Int

View full text Add to dashboard Cite

Objective: Several authors have investigated the background of the process of testicular descent, but the role of the appendix testis has not been studied. The human appendix testis was found to express both estrogen and androgen receptors. We determined and compared the occurrence of testicular appendices intraoperatively in descended and undescended testes. Methods: The number of appendix testis was evaluated retrospectively in 208 boys who underwent uni- or bilateral orchiopexy, hydrocele or hernia repair and the testis was visible during operation. Results: The incidence of appendix testis was 76% (78 in 103) in descended and 24% (30 in 125) in undescended testes. Mean age at orchiopexy was lower in patients without appendix testis (39 months) compared to those patients who were found with appendix (61 months). Conclusion: The incidence of appendix testis was significantly lower (p < 0.05) in undescended testes, suggesting that the appendix testis might play a role in the process of testicular descent.

show abstract

“…Appendiks testis torsiyonu: Testisin üzerinde apendiks testis (Morgagni; hidatid kisti), apendiks epididimis, paradidim, ve vas aberans adı verilen 4 adet Müllerien kanalın bir artıkları, preadolesan dönemdeki çocuklarda artmış olan östrojen hormonları etkisi ile büyür ve pedikülü etrafında kolayca dönebilir (5,16). Skrotumda, testisten ayrı ancak ona yapışık 0.5-1 cm.lik ağ-rılı bir kitle şeklinde ele gelir.…”

Section: Akut Skrotum Yapan Diğer Patolojilerunclassified

AKUT SKROTUM; ÇOCUK ÜROLOJİSİNİN ÖNEMLİ BİR ACİL DURUMU [An important emergency pathology in the pediatric urology: acute scrotum]

Çaman¹,

Cici²,

Pelin³

et al. 2014

ZKTB

View full text Add to dashboard Cite

ÖZETAkut skrotum, inguinoscrotal bölgede ani başlayan kızarıklık, şişlik ve ağrı ile kendini belli eden yenidoğan dönemi ve adolesan dönemi başta olmak üzere her yaş-ta görülebilen çocuklardaki en önemli acil durumlardan biridir. İnguinal kanal ve skrotumda inflamasyon ve tü-möral şişliklerin yer aldığı tüm patolojilerle ayırıcı tanısı yapılmalıdır. Tanıda gecikme veya yanlış tanı konulması, özellikle spermatik kordun torsiyonuna bağlı testiste kalıcı iskemik hasar ve nekrozlara sebep olur. Potansiyel testis kaybı ihtimalinden dolayı akut skrotum düşünülen bütün vakalarda testis torsiyonu daima tanıda akla getirilmelidir. Akut skrotum olgularında özellikle spermatik kord torsiyonu sonrası iskemik nekroz ve testis kaybı sözkonusu olduğundan ayırıcı tanının önemi ve erken cerrahi müdahaleye dikkat çekmek amaçlanmıştır.Anahtar Kelimeler: Erkek çocuk, testis torsiyonu, akut skrotal şişlik, akut scrotum An Important Emergency Pathology in The Pediatric Urology: Akut Scrotum. ABSTRACTAcute scrotum may be seen at any age in boys, especially increases in newborns and adolescenses. The differential diagnosis should be done with inguinal canal pathologies like inflamatory conditions and mass in acute scrotum. A delayed or wrong diagnosis may lead to irreversible damage and ischemic necrosis of the testicle especially due to torsion of the spermatic cord. Due to the potential testicular loss, torsion of spermatic cord must be considered at differential diagnosis of acute scrotum.The purpose ofthis article is to attract attention, in order toreduce the loss of testes inpatients withacutescrotum,especially in spermatic cord torsionand testicularischemic necrosis with early surgicalintervention.

show abstract

Androgen and oestrogen receptor status of the human appendix testis

Cited by 23 publications

References 6 publications

Structural analysis of testicular appendices in patients with cryptorchidism

Structural analysis of testicular appendices in patients with cryptorchidism

Decreased Incidence of Appendix Testis in Cryptorchidism with Intraoperative Survey

AKUT SKROTUM; ÇOCUK ÜROLOJİSİNİN ÖNEMLİ BİR ACİL DURUMU [An important emergency pathology in the pediatric urology: acute scrotum]

Contact Info

Product

Resources

About