Andrew S. Weiner. Review of "Abstraction and the Holocaust"  by Mark Godfrey.

Weiner, Andrew

doi:10.3202/caa.reviews.2008.52

Cited by 11 publications

(14 citation statements)

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“…REM calculations were carried out on the best DG structures (those with the lowest total constraint violations) within the Discover module. The all-atoem AMBER force field (30,31) was used, with a 15 A cutoff for nonbonded interactions and a distance-dependent dielectric constant ( E = 4r) to compensate for lack of explicit solvent. The best DG structures were minimized using 1500 steps of steepest descents minimization, followed by a conjugate gradient minimization to a maximum gradient of 0.01 kcal mol-' A-' .…”

Section: Methodsmentioning

confidence: 99%

Evidence for a C‐terminal turn in PBAN An NMR and distance geometry study

Clark

Prestwich

1996

International Journal of Peptide and Protein Research

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The solution conformation of the pheromone biosynthesis activating neuropeptide (PBAN) of the moth Helicoverpa zea has been determined using homonuclear two‐dimensional nuclear magnetic resonance techniques and distance geometry‐restrained energy minimization. The insect peptide hormone showed a random distribution of conformers in aqueous solution, whereas in a less polar medium of trifluoroethanol and water, a reordering process was observed. In particular, the C‐terminal region (Phe‐Ser‐Pro‐Arg‐Leu‐NH2) adopts a type I′β‐turn conformation, residues 20‐27 are in a helix conformation, and residues 1‐19 exhibit a high degree of flexibility. Direct observation of the C‐terminal β‐turn configuration of PBAN is consistent with a previous report that showed a rigid, cyclic analog of the C‐terminal pentapeptide of PBAN retained pheromonotropic activity [Nachman, R.J., Kuniyoshi, H., Roberts, V.A., Holman, G.M. & Suzuki, A. (1993). Biochem. Biophys. Res. Commun. 661‐666], Furthermore, our results show no interaction between the C‐terminal turn and the rest of the polypeptide chain, thus providing further evidence that the C‐terminal turn is indeed the important conformation recognized by the PBAN receptor. © Munksgaard 1996.

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Section: Methodsmentioning

confidence: 99%

Evidence for a C‐terminal turn in PBAN An NMR and distance geometry study

Clark

Prestwich

1996

International Journal of Peptide and Protein Research

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“…To improve crisis support, 9-8-8 was established as a 3-digit national suicide prevention and mental health hotline through The National Suicide Hotline Designation Act, 151 creating a mental-health-equivalent to 9-1-1. At the state level, in late September, California Governor Gavin Newsom signed Senate Bill 855 into law, which expanded mental health and substance use disorder treatment eligibility, 152 a progressive move that may set the stage for additional states to follow suit. Furthermore, the National Safety Council has developed a National Plan to Address Opioid Misuse, 153 and the American Medical Association recently announced the Behavioral Health Integration (BHI) Collaborative to assist physicians working to combine mental and physical health services in their medical practices, 154 which could transform approaches to patient care for the better.…”

Section: Encouraging Signs and A Path Forwardmentioning

confidence: 99%

Knowing Well, Being Well: well-being born of understanding: Addressing Mental Health and Substance Use Disorders Amid and Beyond the COVID-19 Pandemic

Johnson¹,

Czeisler²,

Rajaratnam³

et al. 2021

Am J Health Promot

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P re-pandemic, the prevalence of mental illness was estimated at 1 in 5 adults, 1 and the US was facing an opioid epidemic. 2 Despite the high prevalence of mental health concerns and substance use disorders, numerous barriers to treatment and systematic limitations, including a shortage of professionals, limited access, lack of adequate funding, and stigma meant that as many as 70% of people with these conditions never sought treatment. 3,4 The cumulative and profound physical, psychological, economic, and social toll of the COVID-19 pandemic has exacerbated the mental health and substance use crisis in America. 4 As Czeisler et al. comprehensively outline in the opening article of this issue of Knowing Well, Being Well, there has already been a very significant adverse impact on mental health. By mid-July, more than 50% of American

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“…To date, only a handful of experimentally confirmed structural models of proteins interacting with their native mineral surfaces have been reported. [11][12][13][14][15][16][17][18] These protein-surface systems include either small extracellular matrix (ECM) proteins or ECM protein domains that are adsorbed onto hydroxyapatite (HAP) crystals. 14,[19][20][21][22][23][24][25][26][27][28][29] These studies suggest that protein secondary structure can change when adsorbed to surfaces.…”

Section: Introductionmentioning

confidence: 99%

Solid-State NMR and MD Study of the Structure of the Statherin Mutant SNa15 on Mineral Surfaces

et al. 2019

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Elucidation of the structure and interactions of proteins at native mineral interfaces is key to understanding how biological systems regulate the formation of hard tissue structures. In addition, understanding how these same proteins interact with non-native mineral surfaces has important implications for the design of medical and dental implants, chromatographic supports, diagnostic tools, and a host of other applications. Here, we combine solid-state NMR spectroscopy, isotherm measurements, and molecular dynamics simulations to study how SNa15, a peptide derived from the hydroxyapatite (HAP) recognition domain of the biomineralization protein statherin, interacts with HAP, silica (SiO 2 ) and titania (TiO 2 ) mineral surfaces. Adsorption isotherms are used to characterize the binding affinity of SNa15 to HAP, SiO 2 , and TiO 2 . We also apply 1D 13 C CP MAS, 1D 15 N CP MAS, and 2D 13 C-13 C DARR experiments to SNa15 samples with uniformly 13 C-and 15 N-enriched residues to determine backbone and side-chain chemical shifts. Different computational tools, namely TALOS-N and molecular dynamics simulations, are used to deduce secondary structure from backbone and side-chain chemical shift data. Our results show that SNa15 adopts an α-helical conformation when adsorbed to HAP and TiO 2 , but the helix largely unravels upon adsorption to SiO 2 . Interactions with HAP are mediated in general by acidic and some basic amino acids, although the specific amino acids involved in direct surface interaction vary with surface. The integrated experimental and computational approach used in this study is able to provide high-resolution insights into adsorption of proteins on interfaces.

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Andrew S. Weiner. Review of "Abstraction and the Holocaust" by Mark Godfrey.

Cited by 11 publications

References 0 publications

Evidence for a C‐terminal turn in PBAN An NMR and distance geometry study

Evidence for a C‐terminal turn in PBAN An NMR and distance geometry study

Knowing Well, Being Well: well-being born of understanding: Addressing Mental Health and Substance Use Disorders Amid and Beyond the COVID-19 Pandemic

Solid-State NMR and MD Study of the Structure of the Statherin Mutant SNa15 on Mineral Surfaces

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