The early history of Spanish paediatrics can be traced back to the 15th-17th century. The Spanish crown ordered to adapt standard textbooks written by royal physicians into the medical curricula of universities. In 1530, the royal physician Luis Lobera de Ávila published a textbook on health and the diseases of children. Then in 1611, Professor Francisco Pérez Cascales made one of the most important Spanish contributions to the paediatric literature, when he wrote about the afflictions of children caused by garrotillo or diphtheria. Àvila and Cascales were important figures in the foundation of paediatrics in Spain. Professor Juan de Soto wrote a treatise on diphtheria referring to the 1613 epidemic in Spain. Professor Luis Mercado was a leading practitioner and chief physician to the Spanish Habsburgs. In his posthumous collection of 1614, he was the first to describe diphtheria as an infectious disease. Gerónimo Soriano published Method and Order of Curing the Diseases of Children in 1690. This was the first written building block for paediatrics and exerted great scientific influence over Spanish, European and American physicians. There were breathtaking advances in paediatrics in Spain in the late 19th and early 20th century including decreased infant morbidity and mortality. These coincided with strengthening and prioritising child health and welfare of children. This much-welcomed change led to creating paediatrics as a medical speciality and the formation of institutions and societies dedicated to this new discipline. The first Spanish paediatric hospitals opened in Madrid in 1877, Barcelona in 1890 and Santa Cruz de Tenerife in 1901. Specialised municipal infant care clinics were set up, and the first university chairs of paediatrics were established. The National School of Child Care was launched in 1923. Smallpox vaccine and diphtheria antitoxin serum were introduced in 1850 and 1910-20, and schools for mothers were established. This period of rapid progress in child health care was guided and advanced by the skills and devotion of great pioneering and inspirational paediatricians. Andrés Martínez Vargas was a prominent figure during this period. 1.1 | Early life, career and influences Vargas was born in Barbastro, Aragon, in 1861 and was the eldest of seven children. In 1877, he began studying medicine at the University of Zaragoza and graduated with distinction. In 1881, he defended his doctoral thesis on the pathogenic theories of chlorosis, at the University of Madrid where he also spent 2 years working as a doctor for a local municipal charity. Vargas spent 1886-1888 in New York learning from the renowned paediatrician Abraham Jacobi (1830-1919), and he also visited Mexico and Cuba. He rejected two offers of a well-paid medical position in Mexico because of his commitment serve to Spain. Having received solid training abroad, he became the Professor of Childhood Diseases at the University of Granada in 1888. Four years later, he was appointed Chair of Childhood Illnesses and the clinical practice i...