Änderungen des nasalen Volumsstromes nach lokaler Applikation des Neuropeptides Substanz-P und von Capsaicin

Wolf, Gerald; D, Loidolt; Saria, Alois; Gamse, R.

doi:10.1055/s-2007-998692

Cited by 16 publications

(7 citation statements)

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“…The present results with respect to blockage after SP stimulation of the nasal mucosa are in accordance with those of Wolf et al [8] and Devillier et al [9]. The presence of this symptom has to be regarded as a di rect action upon the vasculature (nasal sinusoids).…”

Section: Discussionsupporting

confidence: 93%

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The Possible Role of Substance P in the Allergic Reaction, Based on Two Different Provocation Models

Nieber¹,

Baumgarten

Witzel

et al. 1991

Int Arch Allergy Immunol

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It was shown in two different provocation models (nasal and bronchial provocation) that substance P (SP) may play an important role in the neurogenic inflammatory response in upper and lower airway disease. (1) Pretreatment with SP augments the antigen challenge response of the nasal mucosa. (2) The baseline bronchoalveolar lavage (BAL) concentrations of SP are elevated 8-fold in allergies (pollen asthma) as compared with normals, even outside of season. (3) The SP concentration in BAL increases significantly (p <0.05) after bronchial allergen provocation. These findings support a previous hypothesis of an abnormally elevated activity of nonadrenergic-noncholinergic excitatory nerves and are in accordance with the results of a decreased activity of neutral endopeptidase exaggerating neurogenic inflammatory responses in the airways, including bronchomotor tone hyperresponsiveness.

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Section: Discussionsupporting

confidence: 93%

“…Wolf et al [8] and Devillier et al [9] demonstrated an increase in nasal airway resistance, whereas others were un able to confirm this [10]. Similar results were seen for mucociliary activity and nasal secretion [II,12].…”

Section: Introductionmentioning

confidence: 70%

The Possible Role of Substance P in the Allergic Reaction, Based on Two Different Provocation Models

Nieber¹,

Baumgarten

Witzel

et al. 1991

Int Arch Allergy Immunol

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“…The present study shows that long‐term use of benzalkonium chloride nasal spray alone induces mucosal swelling. The nose has a reflex pathway consisting of afferent unmyelinated C fibers and efferent parasympathetic nerves, 22,23 and the activation of nonmyelinated C fibers induces nasal blockage 24 . Long‐term exposure to irritants may cause alterations in vasomotor tone with increased parasympathetic activity, which results in vascular dilatation, increased permeability, edema, and nasal blockage 25…”

Section: Discussionmentioning

confidence: 99%

Effect on the Nasal Mucosa of Long‐Term Treatment With Oxymetazoline, Benzalkonium Chloride, and Placebo Nasal Sprays

Gräf

Hallén

1996

The Laryngoscope

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A parallel, randomized, double-blind study was performed in 30 healthy subjects to investigate the effects on the nasal mucosa of a 1-month treatment with nasal sprays. Ten subjects received oxymetazoline nasal spray; 10 subjects used a nasal spray containing the preservative benzalkonium chloride, and the others were treated with a placebo nasal spray. The three variables that were studied --nasal mucosal swelling, symptom scores, and nasal reactivity-- were estimated by histamine challenge before and after 28 days of treatment. Rhinostereometry was used to measure nasal mucosal swelling and nasal reactivity. After 28 days of use, benzalkonium chloride spray alone induced an increase in nasal mucosal swelling. At the end of the month, the score for nasal stuffiness was significantly higher for the group treated with oxymetazoline than for those treated with benzalkonium chloride. Oxymetazoline nasal spray induced a pronounced increase in nasal reactivity, which was significantly greater than that induced in the placebo group. Long-term use of placebo and benzalkonium chloride nasal sprays also caused an increase in nasal reactivity, but not to the same extent as with the nasal sprays containing oxymetazoline. The authors concluded that long-term use of oxymetazoline induces a sensation of nasal stuffiness, which may be due to unconscious exaggeration of the degree of nasal stuffiness, induced nasal hyperreactivity, or a combination of both. These factors are probably the main reasons for the prolonged use of nasal decongestive sprays and the development of rhinitis medicamentosa. Benzalkonium chloride induces mucosal swelling, which explains why the presence of this preservative in a decongestant spray aggravates rhinitis medicamentosa.

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“…nerves' an activatIOn 0 non-mye mate c-1 ers 10-duces nasal blockage. 22 Exposure to irritants may induce an alteration of the vasomotor tone with increased parasympathetic activity, which results in vascular dilation, increased penneability, edema, and nasal blockage?3 The mucosal instability may be due to that benzalkonium chloride is acting as an irritant.…”

Section: Discussionmentioning

confidence: 99%

Cromolyn Sodium has no Significant Direct Effect on Nasal Mucosal Congestion or Histamine Sensitivity

Talving

Backhaus

Gräf

et al. 1996

American Journal of Rhinology

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The mast cell stabilizing action of cromolyn sodium has long been known. This action reduces symptoms from exposure to allergen. Recent studies, however, also indicate a direct action of cromolyn sodium, which reduces symptoms even if cromolyn sodium is given after allergen exposure. The mechanisms are not yet fully understood. The aims of this study were to examine whether cromolyn sodium has a decongestive effect on the nasal mucosa and whether it reduces the histamine sensitivity of the nasal mucosa. Fourteen healthy volunteers took part in the trial. The study was designed as a double-blind cross-over study, in which the subjects were pretreated with placebo or cromolyn sodium 30 minutes before recording the nasal mucosa swelling and histamine sensitivity. The recordings were made with rhinostereometry. The results show that cromolyn sodium has no decongestive effect and that the mean histamine sensitivity is lower after cromolyn sodium pretreatment, but the difference is not significant.

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Änderungen des nasalen Volumsstromes nach lokaler Applikation des Neuropeptides Substanz-P und von Capsaicin

Cited by 16 publications

References 0 publications

The Possible Role of Substance P in the Allergic Reaction, Based on Two Different Provocation Models

The Possible Role of Substance P in the Allergic Reaction, Based on Two Different Provocation Models

Effect on the Nasal Mucosa of Long‐Term Treatment With Oxymetazoline, Benzalkonium Chloride, and Placebo Nasal Sprays

Cromolyn Sodium has no Significant Direct Effect on Nasal Mucosal Congestion or Histamine Sensitivity

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