Andean Biology in Peru: Scientific Styles on the Periphery

Cueto, Marcos

doi:10.1086/355168

Cited by 65 publications

(19 citation statements)

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“…Beginning with the work of Francois-Gilbert Viault in the 1890s, early studies focused on the Andean pattern of physiological adaptation to high altitude (Cueto 1986). In the 1970s, research began to focus on understanding the physiological adaptations present in populations of the Tibetan Plateau.…”

Section: Human Populations Adapted To High Altitude and Physiologic Rmentioning

confidence: 99%

Human high-altitude adaptation: forward genetics meets the HIF pathway

2014

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Humans have adapted to the chronic hypoxia of high altitude in several locations, and recent genome-wide studies have indicated a genetic basis. In some populations, genetic signatures have been identified in the hypoxia-inducible factor (HIF) pathway, which orchestrates the transcriptional response to hypoxia. In Tibetans, they have been found in the HIF2A (EPAS1) gene, which encodes for HIF-2α, and the prolyl hydroxylase domain protein 2 (PHD2, also known as EGLN1) gene, which encodes for one of its key regulators, PHD2. High-altitude adaptation may be due to multiple genes that act in concert with one another. Unraveling their mechanism of action can offer new therapeutic approaches toward treating common human diseases characterized by chronic hypoxia.

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Section: Human Populations Adapted To High Altitude and Physiologic Rmentioning

confidence: 99%

Human high-altitude adaptation: forward genetics meets the HIF pathway

2014

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“…Using a natural, experimental design presented by having largely independent human populations present on three continents, biological anthropologists, physiologists, and others have studied the three geographic regions where humans have adapted to life on high: the Qinghai‐Tibetan Plateau, the Andean Altiplano, and the Semien Plateau of Ethiopia. Beginning with the work of Francois‐Gilbert Viault in the 1890s, early studies on hypoxia focused on the Andean pattern of physiological adaptation (Cueto, ). It was not until the 1970s that research began on understanding the physiological adaptations present in populations of the Qinghai‐Tibetan Plateau (see Moore and Zamudio, for review).…”

Section: Genomic Scans For High‐altitude Adaptationmentioning

confidence: 99%

Andean and Tibetan patterns of adaptation to high altitude

Bigham

Wilson

Julian

et al. 2013

American J Hum Biol

111

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“…There had been a long tradition among Peruvian and other scientists of conducting studies of physiological responses to high altitude in native and non‐native residents and sojourners. Joseph Barcroft studied residents of Cerro de Pasco in 1921; Monge headed the first Peruvian expedition to Cerro de Pasco in April 1927 with a young physician and scientist, Alberto Hurtado, who later became a leader in the field; and the Institute of Andean Biology was founded at Lima's San Marcos University in 1931 (Cueto, ). These early research efforts were largely experimental and physiological, whereas Baker's approach was anthropological in perspective.…”

Section: Historymentioning

confidence: 99%

A Half Century of High‐Altitude Studies in Anthropology: Introduction to the Plenary Session

Little

Rosemann

Garruto

2013

American J Hum Biol

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Until 50 years ago, high-altitude terrestrial research was conducted largely within the realm of environmental physiology, where interests were focused on physiological mechanisms and mountain exploration. Scientists from the United States, Europe, and Peru had developed sophisticated physiological models of adaptation and acclimatization to the hypoxia of high altitude, but very little research had been conducted on permanent residents, particularly natives of high altitude in the two major regions of the world-the Andes and the Himalayas. In 1962, Raul T. Baker initiated a project at the Pennsylvania State University to explore the responses of indigenous Peruvians to the major stresses at altitude: hypoxia and cold. Approaches to this early research were anthropological in perspective and centered on populationlevel studies with an evolutionary approach. Studies were conducted by applying a combination of physiological experimental methods, simulated field experiments, and extended anthropological field observations. Early hypotheses at this time were that heredity played a major role in the adaptive complexes in native high-altitude residents. These early hypotheses were later modified to incorporate or replace the genetic hypotheses with developmental adaptation models. A half century of research within anthropology and research in other fields has presented a vastly more complex and integrated picture of high-altitude adaptation in native residents. Recent studies incorporate physiology and oxygen transport, population and molecular genetics, reproduction, growth, and development. The history and current status of high-altitude research and its anthropological applications are treated in papers from this plenary symposium. Am. J. Hum. Biol. 25:148-150, 2013.

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Andean Biology in Peru: Scientific Styles on the Periphery

Cited by 65 publications

References 0 publications

Human high-altitude adaptation: forward genetics meets the HIF pathway

Human high-altitude adaptation: forward genetics meets the HIF pathway

Andean and Tibetan patterns of adaptation to high altitude

A Half Century of High‐Altitude Studies in Anthropology: Introduction to the Plenary Session

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