North American employees face substantial challenges in managing their work and family lives. Drawing from Hobfoll’s 2001 conservation of resources (COR) theory, work-family scholars have argued that some resources can be effective in buffering conflict in the work-family interface. We analyze data from a national sample of Canadian workers ( N = 3,431) to assess how two components of religion/spirituality—religious attendance and divine control—buffer the mental health effects of work-to-family conflict (WFC) and family-to-work conflict (FWC). Results suggest that both work-to-family conflict and family-to-work conflict were associated with higher levels of psychological distress. Our results further reveal that religious attendance buffered the pernicious effects of both WFC and FWC for psychological distress, while divine control only buffered the effects of FWC. These patterns did not appear to differ by gender. Given increasing rates of work-family strain in the North American context, out findings call for a broadening of the literature on the work-family interface, one that takes into consideration the overlooked role of religion and spirituality.