Ancient Schwannoma of Upper Lip: Case Report With Distinct Histologic Features and Review of the Literature

Humber, Craig C.; Copete, Maria; Hohn, F.I.

doi:10.1016/j.joms.2010.11.024

Cited by 33 publications

(34 citation statements)

References 20 publications

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“…Several histological variants of schwannomas, have been described. The histological variant of this tumor described as “Ancient schwannoma” shows specific histological characteristics such as degenerative changes and the presence of pleomorphic nuclei, hemorrhagic phenomena or microcyst formation (11,12). Ancient schwannomas tend to be large tumors of long duration and are really rare in the oral cavity.…”

Section: Introductionmentioning

confidence: 99%

Ancient Schwannoma of the hard palate. An uncommon case report and review

et al. 2013

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Schwannoma or neurilemmoma is an infrequent benign tumor in the oral cavity that originates from the Schwann cells on the neural sheath of the peripheral nerves. Schwannomas are frequently located in the soft tissues of head and neck region, but only a 1 to 12% of them are located in the oral cavity. Some histological variants of schwannoma have been described including the cellular, plexiform, epithelioid, ancient, and melanocytic types. The “ancient schwannoma” is an uncommon variant of this tumor that shows specific histological characteristics, and is rare in the oral cavity with less than 15 cases described on the literature. Most of them were located in the tongue or in the floor of the mouth, being the hard palate an extremely rare localization. We present a new clinical case of an ancient schwannoma with a long time of evolution, arising from the nasopalatine nerve, and located in the hard palate of a 35 year old female. We also review the main clinical and histological characteristics of this pathology. Key words:Ancient schwannoma, neurilemmoma, palate, schwannoma.

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Section: Introductionmentioning

confidence: 99%

Ancient Schwannoma of the hard palate. An uncommon case report and review

et al. 2013

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“…Benign nerve sheath tumours, including schwannoma (neurilemmoma) and neurofibroma, are encountered in oral and perioral locations 5. Schwannomas are infrequent, benign neoplasms that can rise from any cranial, peripheral or autonomic nerve that contain schwann cells.…”

Section: Discussionmentioning

confidence: 99%

Intraoral schwannoma - a report of two cases

Kurup¹,

Thankappan

Krishnan³

et al. 2012

Case Reports

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Schwannomas, also known as neurilemmomas, are uncommon neoplasms, derived from schwann cells. These neoplasms, although rare, should be considered in the differential diagnosis of slow growing tumour masses of the oral cavity. The growth of these tumours sometimes causes displacement and compression of the nerve of origin, giving rise to clinical signs and symptoms. It can develop at any age and there is no sex predilection. Intraorally, the tongue is the most common site followed by the palate, floor of the mouth, buccal mucosa, lips and jaws. Surgical excision is the treatment of choice for schwannomas, with few reports of recurrence or malignant transformation. In this paper, the authors report two cases of patients with intraoral schwannoma, where the preoperative clinical diagnosis was inconclusive and final diagnosis was established based on radiographic and histopathological examination.

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“…Ancient schwannoma is another further rare variant of intraoral schwannomas. To date, only limited cases of ancient schwannomas have been reported in the oral cavity [5][6][7][8][9][10][11][12][13][14][15][16] . We report here on additional two cases of ancient schwan- (Fig.…”

Section: Introductionmentioning

confidence: 99%

“…Humber et al 16 Table 1. The etiology and natural history of intraoral schwannoma have not been properly characterized, but the nerve sheath of origin has been regarded to be the branches of the mental nerve and inferior alveolar nerve 13 .…”

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“…Malignant transformation of intraoral schwannomas is rare, be it the conventional or ancient variant. Complete surgical excision is the treatment of choice for intraoral schwannomas [5][6][7][8][9][10][11][12][13][14][15][16] , and the prognosis is excellent. When the tumor is well-encapsulated it is easily treated with surgery, and the difficulty resides in preserving the associated nerve by performing careful dissection.…”

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Ancient schwannoma in oral cavity: a report of two cases

Kim

Chung

Park

et al. 2011

J Korean Assoc Oral Maxillofac Surg

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(J Korean Assoc Oral Maxillofac Surg 2011;37:530-4) This paper reports two cases of schwannomas arising from the oral cavity. One is an intraoral ancient schwannoma located at the left cheek, which evolved over a period of 13 years. The tumor was a well-demarcated buccal mass, which was located in the left lower first premolar area, with an obliterated the buccal vestibule, leaving the overlying mucosa intact. The second case was a central intraosseous schwannoma located from the left lower 1st molar periapical area to the left 3rd molar periapical area. Pathologically, the first mass was composed of the spindle shaped tumor cells with wavy nuclei beneath the fibroconnective tissue of the gingiva but second case mass was not. Occasional nuclear pleomorphism was observed but mitosis or necrosis was absent. There were Antoni A and B areas along with strong, diffuse staining with the S-100 protein. Ancient schwannomas were diagnosed. Schwannoma is a slow-growing benign tumor, and an ancient schwannoma that shows cellular atypism is a variant of a schwannoma caused by purely degenerative changes. To date, only limited cases of ancient schwannomas in the oral cavity have been reported.

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Ancient Schwannoma of Upper Lip: Case Report With Distinct Histologic Features and Review of the Literature

Cited by 33 publications

References 20 publications

Ancient Schwannoma of the hard palate. An uncommon case report and review

Ancient Schwannoma of the hard palate. An uncommon case report and review

Intraoral schwannoma - a report of two cases

Ancient schwannoma in oral cavity: a report of two cases

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