Ancient herbal component may be a novel therapeutic for gouty arthritis

Chen, Yibo; Chen, Xin

doi:10.1002/jlb.3ce1018-384r

Cited by 7 publications

(2 citation statements)

References 10 publications

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“…This may be due to the analgesic effect of Rhizoma Atractylodis, anti-inflammatory and antipyretic effect of Rhizoma Cyperi, antipyretic effect of Radix Achyranthis bidentatae, and analgesic effect of Coicis Semen in the prescription of heat-clearing and dampness-removing formula. The combination of these drugs not only significantly inhibited joint inflammation, but also promoted uric acid metabolism [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Influence of intervention treatment by “heat-clearing and diuresis-promoting” prescription on NALP3, an inflammatory factor in acute gouty arthritis

Liu

et al. 2022

J Orthop Surg Res

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Background To investigate the efficacy of Qingre Lishi Decoction(QLRD), in the treatment of acute gouty arthritis, and its influence on the expression levels of inflammatory factor nucleotide-binding oligomerization domain-like receptor(NALP 3) in patients. Methods A total of 78 patients with acute gouty arthritis admitted to our hospital were randomly divided into the control group and the observation group, with 39 cases in each group. The control group was given basic treatment and colchicine tablets, and the observation group was given “heat-clearing and diuresis-promoting” prescription for intervention treatment. The main symptom score, treatment effective rate and laboratory indexes of the two groups were compared 7 days after treatment. Results After treatment, the scores of joint redness, hot pain, joint flexion and extension disorder, oliguria and constipation were improved in both groups, and the improvement degree in observation group was higher than that in control group (P < 0.05); the clinical effective rate in the observation group (94.87%) was higher than that in the control group (76.92%). The serum uric acid (UA), erythrocyte sedimentation rate (ESR), interleukin-1β (IL-1β) and NALP3 showed a decreasing trend, and the decrease degree of each index in observation group was higher than that in control group (P < 0.05). Conclusion The “heat-clearing and diuresis-promoting” prescription for intervention treatment can effectively improve the clinical symptoms of patients with acute gouty arthritis and reduce the level of inflammatory factor NALP3, maintaining remarkable effect.

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Section: Discussionmentioning

confidence: 99%

Influence of intervention treatment by “heat-clearing and diuresis-promoting” prescription on NALP3, an inflammatory factor in acute gouty arthritis

Liu

et al. 2022

J Orthop Surg Res

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“…We cite 14 ongoing TCM clinical trials (Table 2); 19 most used TCM herbs (Table 3) for the prevention and treatment of Covid-19 (SARS-CoV-2) infection, as well as the TCM recommended by 6 th editions Guidelines of Diagnosis and Treatment for Covid-19 (Table 4). 40 and the results showed an interaction between AC2 and some of the TCM-derived compounds, among others: scutellarin, baicalin, hesperetin, glycyrrhizin and nicotianamine 40 . We then expect these compounds or herbal plants containing such compounds to restrain the infection of Covid-19.…”

Section: Ravintsara Essential Oilmentioning

confidence: 92%

The Impact of Natural Compounds in the Fight Against Covid-19: A Review

Kiaka¹,

Moundzounga²,

Yasmine³

2020

Int Res J Pharm

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Over 200,000 lives have been claimed by Covid-19 all over the world. The impact of this disease has led the World Health Organization (WHO) to declare COVID-19 as a global disaster. Diverse precautions have been established to wipe out this disease and hence, prevent it from causing severe damages on earth. However, these precautions could not fully eradicate the disease since there is still a lack of a preventive vaccine or any antiviral treatments. Hence, there is a crucial need to find a platform where novel antiviral drugs can be developed, and natural compounds serve as an excellent source where this discovery can be found. This brief study aims to provide a general review of some of the recent researches, in which natural compounds were studied for their antiviral effects.

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Effects of Total Saponins from Dioscorea Nipponica Makino on Monosodium Urate-Induced M1-Polarized Macrophages through Arachidonic Acid Signaling Pathway: An in vitro Study

Zhou

Sun

Liu

2022

Chin. J. Integr. Med.

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Ancient herbal component may be a novel therapeutic for gouty arthritis

Abstract: Discussion on reprogrammed arachidonic acid metabolism mediated by COX2, 5‐LOX and CYP4A alleviate gouty arthritis by salidroside.

Cited by 7 publications

References 10 publications

Influence of intervention treatment by “heat-clearing and diuresis-promoting” prescription on NALP3, an inflammatory factor in acute gouty arthritis

Influence of intervention treatment by “heat-clearing and diuresis-promoting” prescription on NALP3, an inflammatory factor in acute gouty arthritis

The Impact of Natural Compounds in the Fight Against Covid-19: A Review

Effects of Total Saponins from Dioscorea Nipponica Makino on Monosodium Urate-Induced M1-Polarized Macrophages through Arachidonic Acid Signaling Pathway: An in vitro Study

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