Ancient Coevolution of Baculoviruses and Their Insect Hosts

Herniou, Elisabeth A.; Olszewski, Julie A.; O’Reilly, David R.; Cory, Jenny S.

doi:10.1128/jvi.78.7.3244-3251.2004

Cited by 146 publications

(143 citation statements)

References 51 publications

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“…Alk-exo gene clustering suggested that baculovirus clustered according to the different orders of insects. This demonstrates the existence of a co-evolutionary relationship between the virus and its host; similar results have been obtained from cluster analysis of the lef-8 gene and AC22 gene studied by Herniou et al (2004). Because the ubiquitin gene of baculovirus and hosts have very high homology, the evolutionary distance between the ubiquitin gene in the virus and insect hosts was not clear, both between and within groups.…”

Section: Discussionsupporting

confidence: 59%

Evolutionary analysis of the ubiquitin gene of baculovirus and insect hosts

Ma¹,

Zhang²,

Xia³

et al. 2015

Genet. Mol. Res.

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ABSTRACT.Baculovirus is the only virus that has been found to encode the ubiquitin protein. In this study, ubiquitin sequences from 16 insects and 49 viruses were collected and compared. The resulting sequences were aligned with virus genomes. Then MAGE 5.0, k-estimated software, as well as other software programs were used for systemic evolutionary, selection pressure, and evolutionary distance analysis. The results of the pairwise ratio of non-synonymous to synonymous substitution values and evolutionary distances showed that ubiquitin from baculovirus and insect hosts have been under purifying selection during evolution and are thus evolutionarily conserved. Moreover, genes from insect hosts were more conserved than those in baculovirus. Analysis of the non-synonymous to synonymous substitution rates at each site and entropy calculations revealed the evolutionary status of every site in the ubiquitin genes of baculovirus and their hosts. Genome locations and phylogenetic trees indicated that granuloviruses and non-photosynthetic vegetation evolved, and granulovirus evolution was more similar to that of insect hosts. Our results suggest that the ubiquitin gene in baculovirus may have been acquired through horizontal transfer from the host.

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Section: Discussionsupporting

confidence: 59%

Evolutionary analysis of the ubiquitin gene of baculovirus and insect hosts

Ma¹,

Zhang²,

Xia³

et al. 2015

Genet. Mol. Res.

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“…The Aquarium Control and DOC samples contained a large fraction of sequences similar to ssDNA viruses from plants (white bars) such as geminiviruses and nanoviruses (39). Invertebrate infecting viruses (black bars) were also abundant (Ͼ60%) within the time zero library and were mostly similar to the baculoviruses and polydnaviruses, 2 viral families that predominantly infect arthropods (40)(41)(42). However, a caveat to this analysis is that the predicted host range is biased by the larger number of completed vertebrateassociated viral genomes.…”

Section: Coral-associated Viruses Infect a Range Of Hostsmentioning

confidence: 99%

Metagenomic analysis indicates that stressors induce production of herpes-like viruses in the coral Porites compressa

Thurber

Barott²,

Hall³

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

196

231

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During the last several decades corals have been in decline and at least one-third of all coral species are now threatened with extinction. Coral disease has been a major contributor to this threat, but little is known about the responsible pathogens. To date most research has focused on bacterial and fungal diseases; however, viruses may also be important for coral health. Using a combination of empirical viral metagenomics and real-time PCR, we show that Porites compressa corals contain a suite of eukaryotic viruses, many related to the Herpesviridae. This coral-associated viral consortium was found to shift in response to abiotic stressors. In particular, when exposed to reduced pH, elevated nutrients, and thermal stress, the abundance of herpes-like viral sequences rapidly increased in 2 separate experiments. Herpes-like viral sequences were rarely detected in apparently healthy corals, but were abundant in a majority of stressed samples. In addition, surveys of the Nematostella and Hydra genomic projects demonstrate that even distantly related Cnidarians contain numerous herpes-like viral genes, likely as a result of latent or endogenous viral infection. These data support the hypotheses that corals experience viral infections, which are exacerbated by stress, and that herpes-like viruses are common in Cnidarians.coral reefs ͉ disease ͉ Herpesviridae ͉ viral-like particles ͉ virome

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“…For horses A1 and A2 ∼0.01% of sequence reads (2,954 and 3,522 reads, respectively) mapped to members of the Flaviviridae; 0.06% (9,116) of antitoxin 2 reads mapped to the same virus family. In addition to the abundance of Flaviviridae reads in each sample, horse A1 had a single read pair mapping to the Baculoviridae, a family of insect viruses (10), and another read pair derived from the Adenoviridae family, mapping to the region found in laboratory recombination vectors (11)(12)(13); horse A2 contained 80 read pairs deriving from a 298-nt contiguous region in pepper mild mottle virus, a plant virus from the Virgaviridae family. These reads likely represent artifactual contamination introduced during sample collection and library preparation.…”

Section: Viral Sequence Detection Leads To Assembly Of a Highly Divermentioning

confidence: 99%

Identification of a previously undescribed divergent virus from the Flaviviridae family in an outbreak of equine serum hepatitis

Chandriani

Skewes-Cox

Zhong

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

142

182

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Theiler's disease is an acute hepatitis in horses that is associated with the administration of equine blood products; its etiologic agent has remained unknown for nearly a century. Here, we used massively parallel sequencing to explore samples from a recent Theiler's disease outbreak. Metatranscriptomic analysis of the short sequence reads identified a 10.5-kb sequence from a previously undescribed virus of the Flaviviridae family, which we designate "Theiler's disease-associated virus" (TDAV). Phylogenetic analysis clusters TDAV with GB viruses of the recently proposed Pegivirus genus, although it shares only 35.3% amino acid identity with its closest relative, GB virus D. An epidemiological survey of additional horses from three separate locations supports an association between TDAV infection and acute serum hepatitis. Experimental inoculation of horses with TDAV-positive plasma provides evidence that several weeks of viremia preceded liver injury and that liver disease may not be directly related to the level of viremia. Like hepatitis C virus, the best characterized Flaviviridae species known to cause hepatitis, we find TDAV is capable of efficient parenteral transmission, engendering acute and chronic infections associated with a diversity of clinical presentations ranging from subclinical infection to clinical hepatitis.epidemiology | veterinary virology | metagenomics | deep sequencing | pathogen discovery

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Ancient Coevolution of Baculoviruses and Their Insect Hosts

Cited by 146 publications

References 51 publications

Evolutionary analysis of the ubiquitin gene of baculovirus and insect hosts

Evolutionary analysis of the ubiquitin gene of baculovirus and insect hosts

Metagenomic analysis indicates that stressors induce production of herpes-like viruses in the coral Porites compressa

Identification of a previously undescribed divergent virus from the Flaviviridae family in an outbreak of equine serum hepatitis

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