Anchoring Junctions in the Oral Mucosa: Adherens Junctions and Desmosomes

Wan, Hong; Gadmor, Hanan; Brown, Louise

doi:10.1007/978-3-319-56065-6_3

Cited by 4 publications

(6 citation statements)

References 132 publications

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“…Oral epithelium integrity is maintained through highly specific junctional complexes between epithelial cells. Three types of epithelial cell junctions have been described: tight junctions (TJs), gap junctions (GJs), and anchoring junctions [ 10 , 11 , 12 , 13 ]. Tight junctions form the closest cell–cell interactions in the apical area of oral epithelial cells, working as a restrictive gate for the passage of water, electrolytes, and other small molecules.…”

Section: Oral Mucosamentioning

confidence: 99%

“…Thus, they provide direct communication between adjacent cells and the exchange of small molecules and ions. Anchoring junctions are classified as adherens junctions (AJs), desmosomes, and hemi-desmosomes [ 12 ]. Adherens juntions are protein complexes situated below TJs that strongly hold cells.…”

Section: Oral Mucosamentioning

confidence: 99%

“…Moreover, desmosomes act as surface receptors that mediate cellular differentiation and proliferation. Adhesion between the epithelium and connective tissue is provided by hemidesmosomes (half of a desmosome), which link the intermediate filament network of epithelial cells to the underlying basement membrane [ 11 , 12 ]. Since the structure and functions of all of the abovementioned cell–cell junctions are key to preserve epithelial barrier integrity, their disruption has been linked to infections, autoimmune diseases, allergies, and cancer disorders [ 11 , 14 , 15 , 16 , 17 , 18 , 19 ].…”

Section: Oral Mucosamentioning

confidence: 99%

See 2 more Smart Citations

Oral Mucosa as a Potential Site for Diagnosis and Treatment of Allergic and Autoimmune Diseases

Gómez‐Casado

Sánchez-Solares

Izquierdo

et al. 2021

Foods

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Most prevalent food allergies during early childhood are caused by foods with a high allergenic protein content, such as milk, egg, nuts, or fish. In older subjects, some respiratory allergies progressively lead to food-induced allergic reactions, which can be severe, such as urticaria or asthma. Oral mucosa remodeling has been recently proven to be a feature of severe allergic phenotypes and autoimmune diseases. This remodeling process includes epithelial barrier disruption and the release of inflammatory signals. Although little is known about the immune processes taking place in the oral mucosa, there are a few reports describing the oral mucosa-associated immune system. In this review, we will provide an overview of the recent knowledge about the role of the oral mucosa in food-induced allergic reactions, as well as in severe respiratory allergies or food-induced autoimmune diseases, such as celiac disease.

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Section: Oral Mucosamentioning

confidence: 99%

Section: Oral Mucosamentioning

confidence: 99%

Section: Oral Mucosamentioning

confidence: 99%

See 1 more Smart Citation

Oral Mucosa as a Potential Site for Diagnosis and Treatment of Allergic and Autoimmune Diseases

Gómez‐Casado

Sánchez-Solares

Izquierdo

et al. 2021

Foods

View full text Add to dashboard Cite

show abstract

“…The binding of calcium in the hinge juxtaposition prevents its flexing. Thus, a rigid and curved shape is formed in the extracellular domain (Wan et al, 2018[ 77 ]). The link between the N-terminal domains of cadherins from 2 opposing cells generates cell adhesion.…”

Section: Anchoring Junctionsmentioning

confidence: 99%

“…The presence of auto-antibodies directed against Dsg1 causes the generation of blisters in the upper granular layers of the epidermis in pemphigus foliaceus . Pemphigus vulgaris is associated with oral lesions and is accompanied by the production of Dsg3 auto-antibodies (Wan et al, 2018[ 77 ]).…”

Section: Anchoring Junctionsmentioning

confidence: 99%