Ancestry-related assortative mating in Latino populations

Risch, Neil; Choudhry, Shweta; Via, Marc; Basu, Analabha; Sebro, Ronnie; Eng, Celeste; Beckman, Kenneth B.; Thyne, Shannon; Chapela, Rocío; Rodríguez‐Santana, José; Rodríguez-Cintrón, William; Avila, Pedro C.; Ziv, Elad; Burchard, Esteban G.

doi:10.1186/gb-2009-10-11-r132

Cited by 93 publications

(131 citation statements)

References 32 publications

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“…assortative mating | genomic ancestry | homogamy M ate selection in human populations is a topic of broad general and academic interest, with important implications for economics (1), sociology (2), psychology (3), and genetics (4,5). Studies from all of these fields have uncovered myriad genetic and socioeconomic factors that are correlated between partners.…”

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confidence: 99%

“…Recent work from several groups suggests that genetic factors contribute to human mating preferences (5,(7)(8)(9)(10). In European populations, there is evidence that individuals tend to be attracted to people with major histocompatibility complex (MHC) regions that are distinct from their own (7,8).…”

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confidence: 99%

“…In European populations, there is evidence that individuals tend to be attracted to people with major histocompatibility complex (MHC) regions that are distinct from their own (7,8). In Latinos, genotypes of ancestryinformative markers were shown to be positively correlated in partners (5). A recent study of non-Hispanic whites in the United States found that spouses were more genetically similar than random pairs of individuals; however, genetic assortment was substantially smaller than educational assortment in the same couples (11).…”

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Genetic and socioeconomic study of mate choice in Latinos reveals novel assortment patterns

Zou

Park

Burchard

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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Nonrandom mating in human populations has important implications for genetics and medicine as well as for economics and sociology. In this study, we performed an integrative analysis of a large cohort of Mexican and Puerto Rican couples using detailed socioeconomic attributes and genotypes. We found that in ethnically homogeneous Latino communities, partners are significantly more similar in their genomic ancestries than expected by chance. Consistent with this, we also found that partners are more closely related—equivalent to between third and fourth cousins in Mexicans and Puerto Ricans—than matched random male–female pairs. Our analysis showed that this genomic ancestry similarity cannot be explained by the standard socioeconomic measurables alone. Strikingly, the assortment of genomic ancestry in couples was consistently stronger than even the assortment of education. We found enriched correlation of partners’ genotypes at genes known to be involved in facial development. We replicated our results across multiple geographic locations. We discuss the implications of assortment and assortment-specific loci on disease dynamics and disease mapping methods in Latinos.

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Genetic and socioeconomic study of mate choice in Latinos reveals novel assortment patterns

Zou

Park

Burchard

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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“…This panel of markers has been used to characterize admixture proportions in previous studies (Pereira et al, 2012; Risch et al, 2009). Briefly, Yaeger's panel includes biallelic single nucleotide polymorphisms (SNPs) that were selected from the Affymetrix Human 100K SNP chip, based on their information content to infer Native American, European, and African ancestry.…”

Section: Methodsmentioning

confidence: 99%

Analysis of admixture proportions in seven geographical regions of the state of Guerrero, Mexico

Cahua-Pablo

Cruz

Almaguer

et al. 2017

American J Hum Biol

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ObjectiveMexico's current population structure has been defined by admixture between European, Native American, and to some extent African, groups that started in the sixteenth century. The aim of this research was to analyze the relative contributions of these continental population groups to the seven regions of the state of Guerrero, Mexico.MethodsA total of 104 ancestry informative markers were analyzed in 480 unrelated women from the seven regions of the state of Guerrero. The individual ancestry proportions were estimated using the software ADMIXMAP v3.2.ResultsThe relative Native American, European and African ancestral contributions to the whole sample were estimated to be 69%, 27%, and 1.9%, respectively. We observed significant differences in admixture proportions across the regions. The highest average Native American ancestry was found in the Montaña region and the lowest in Costa Grande. Conversely, the highest European contribution was observed in Costa Grande. The highest African contributions were observed in the regions of Costa Chica and Costa Grande.ConclusionsThe genetic structure of the population of Guerrero reflects quite well the historical processes that have occurred in this state. Native American population settlements were mainly in the regions of Montaña, Norte, and Centro, where the highest indigenous genetic contribution is observed today. European settlers came from the center of the state to regions with significant agricultural and mining activities. The highest African contributions are observed in coastal regions, in agreement with historical evidence about slave trade routes in the Americas.

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“…also showed that this increase is directly proportional to the variance of the genotype frequency between sub-populations when the same genotypes comprise the mating types. Sub-population or ancestry-related positive assortative mating (Risch et al, 2009; results in population stratification, and is seen at all loci where the allele frequency differs between sub-populations.…”

Section: Introductionmentioning

confidence: 99%

A brief note on the resemblance between relatives in the presence of population stratification

Sebro

Risch

2012

Heredity

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Population stratification occurs when a study population is comprised of several sub-populations, and can result in increased false positive findings in genomewide-association studies. Recently published work shows that sub-population-specific positive assortative mating at the genotypic level results in population stratification. We show that if the allele frequency of a single nucleotide polymorphism responsible for a trait varies between sub-populations and there is no dominance variance, then the heritability of the trait increases, primarily due to an increase in the additive genetic variance of the trait.

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Ancestry-related assortative mating in Latino populations

Abstract: Examination of ancestry-informative genetic markers shows that Puerto Rican and Mexican populations have shown strong assortative mating that continues to this day.

Cited by 93 publications

References 32 publications

Genetic and socioeconomic study of mate choice in Latinos reveals novel assortment patterns

Genetic and socioeconomic study of mate choice in Latinos reveals novel assortment patterns

Analysis of admixture proportions in seven geographical regions of the state of Guerrero, Mexico

A brief note on the resemblance between relatives in the presence of population stratification

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