Ancestry evaluation in a population sample of the Tunja city, Department of Boyacá - Colombia

Sanchez, Izquel; Mendoza, L.; Rincón, A.L.; Aguirre, D.; Builes, J.J.

doi:10.1016/j.fsigss.2019.10.142

Cited by 3 publications

(3 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The predominant phototypes in the population analyzed were phototype III and IV and light to dark brown hair and eye color. According to genetic ancestry studies of this population (Cundi-boyacense), it has been determined that the genetic background is represented by 0.51% to 4.2% African, 55% European and 36% to 40.8% Native American [29,30]. It is possible that in this population the enrichment of African ancestral alleles (G; 374L) that participate in a higher production of eumelanin are related to the protection for melanoma and that together with other genetic and environmental factors determine the incidence of this disease.…”

Section: Discussionmentioning

confidence: 99%

SLC45A2 Germilne Variants in Colombian Population with Melanoma

Garcia-Garay,

Parra-Tovar,

Gutierrez-Castañeda

2022

Preprint

View full text Add to dashboard Cite

The SLC45A2 gene, located at chromosome 5p13.2, is involved in melanin biosynthesis. Single Nucleotide Variant (SNVs) in this gene have been associated with normal variation of skin, eye and hair color in human population. Additionally, there are SNVs like L374F (C/T) and E272K (c/G) that are associated with protection against melanoma. In this project, in a survey of Bogota, Colombia people, both SNVs mentioned before were evaluated in a case and controls study. DNA samples were isolated with commercial kits, prior signing of the informed consent. The genotypification was done through RT-PCR HRM technique. We found that 19% of the individuals were classified as phototype II, 70% phototype III and 11% phototype IV. In addition, 80% of the subjects had brown eyes and dark-brown hair. Both SNVs were in Hardy-Weinberg equilibrium. Allelic frequencies were C=0.644, T=0.356 and C=0.756, G=0.244 for E272K and L374F, respectively. None of the variants analyzed had association with melanoma developing. Haplotype analysis adjusted by sex and phototype shown a higher risk of having melanoma with individuals having CG genotype, OR:2.75 (IC 95% 1.22-6.22 p=0.021). The frequencies found for the variants of SLC45A2 gene in this project is accord with many other studies done with Latin-American population, were phototype II and III are the prevalent in people.

show abstract

Section: Discussionmentioning

confidence: 99%

SLC45A2 Germilne Variants in Colombian Population with Melanoma

Garcia-Garay,

Parra-Tovar,

Gutierrez-Castañeda

2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Analysis was carried out using the "Use Population Information" option, and allele frequencies were correlated and updated using only individuals with POPFLAG = 1. A gradient map based on the proportions of European ancestry in admixed South American populations [14,24,25,[27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43] was designed in the Surfer software v.16.0.330 (Golden Software, LLC, Golden, CO, USA), using the Kriging method for interpolating frequency values.…”

Section: Discussionmentioning

confidence: 99%

The Ancestry of Eastern Paraguay: A Typical South American Profile with a Unique Pattern of Admixture

Simão¹,

Ribeiro²,

Vullo³

et al. 2021

Genes

View full text Add to dashboard Cite

Immigrants from diverse origins have arrived in Paraguay and produced important demographic changes in a territory initially inhabited by indigenous Guarani. Few studies have been performed to estimate the proportion of Native ancestry that is still preserved in Paraguay and the role of females and males in admixture processes. Therefore, 548 individuals from eastern Paraguay were genotyped for three marker sets: mtDNA, Y-SNPs and autosomal AIM-InDels. A genetic homogeneity was found between departments for each set of markers, supported by the demographic data collected, which showed that only 43% of the individuals have the same birthplace as their parents. The results show a sex-biased intermarriage, with higher maternal than paternal Native American ancestry. Within the native mtDNA lineages in Paraguay (87.2% of the total), most haplogroups have a broad distribution across the subcontinent, and only few are concentrated around the Paraná River basin. The frequency distribution of the European paternal lineages in Paraguay (92.2% of the total) showed a major contribution from the Iberian region. In addition to the remaining legacy of the colonial period, the joint analysis of the different types of markers included in this study revealed the impact of post-war migrations on the current genetic background of Paraguay.

show abstract

“…[34] and I. Sanchez et al [35], respectively; with around 300 beds to care for patients with multiple diseases, from the simplest to the most difficult to treat. In addition to the above, and taking into account that hospitals represent one of the most complex types of organization, whether for its critical service or for the many highly qualified people, materials, suppliers and skills required to provide that service, such as described by R. Rijo et al [36], it follows that the institution evaluated is highly complex, but medium capacity by Colombian standards, according to the classification shown by J. D. Moreno R. [37].…”

Section: Initial Sanitary Environmental and Biosafety Diagnosismentioning

confidence: 99%

Diagnosis Of Hospital, Hazardous and Similar Waste Management of an Institution Providing Health Services – IPHS

et al. 2020

View full text Add to dashboard Cite

Introduction: This article presents the results of the research carried out from January 2018 to December 2019, in an institution providing third-level health services (IPHS), located in Tunja (Boyacá), in eastern central Colombia. Problem: There are various difficulties related to the management of waste produced by the IPHS; Irresponsible practices cause the spread of infections, which have repercussions in critical situations locally, regionally and internationally. Objective: To evaluate the management of hospital, hazardous and similar waste (HCWM), carried out by an IPHS, and to formulate strategies for its improvement. Methodology: The research was carried out in three (3) stages: data collection (through inspections and weighing of waste), data analysis (for the qualification and quantification of the waste), and finally, some guidelines for its proper management were proposed, based on the context of the organization. Results: The IPHS generated 397.6 tonnes of hospital, hazardous and similar waste (MW). Biohazard waste (BW) predominated over the others (54.11%), followed by usable non-hazardous waste - UNHW (41.53%) and chemical and pharmaceutical waste - CPW (4, 37%). Conclusion: The entity complies with the main requirements of the national government, identifying good utilization and biosecurity practices; however, under diagnosis and with the implementation of guidelines emanating from research, it is possible to optimize procedures. Originality: The guidelines and activities for the separation, use and internal collection of waste within an IPHS were observed and then interrelated with the services provided and their resources. This work could be a guideline for related institutions. Limitations: The article focuses on the internal and non-external management of MW.

show abstract

Ancestry evaluation in a population sample of the Tunja city, Department of Boyacá - Colombia

Cited by 3 publications

References 5 publications

SLC45A2 Germilne Variants in Colombian Population with Melanoma

SLC45A2 Germilne Variants in Colombian Population with Melanoma

The Ancestry of Eastern Paraguay: A Typical South American Profile with a Unique Pattern of Admixture

Diagnosis Of Hospital, Hazardous and Similar Waste Management of an Institution Providing Health Services – IPHS

Contact Info

Product

Resources

About