Ancestry and Pathology in King Tutankhamun's Family

Hawass, Zahi; Gad, Yehia Z.; Ismail, Somaia; Khairat, Rabab; Fathalla, Dina; Hasan, Naglaa; Ahmed, Amal; Elleithy, Hisham; Ball, Markus; Gaballah, Fawzi; Wasef, Sally; Fateen, Mohamed; Amer, Hamada H.; Gostner, Paul; Selim, Ashraf; Zink, Albert; Pusch, Carsten M.

doi:10.1001/jama.2010.121

Cited by 245 publications

(185 citation statements)

References 32 publications

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“…Aqueous solutions of PCR components were screened for purity with a highly sensitive contamination monitoring protocol (intra Alu-PCR) reported elsewhere 39,40 .…”

Section: Methodsmentioning

confidence: 99%

New insights into the Tyrolean Iceman's origin and phenotype as inferred by whole-genome sequencing

et al. 2012

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The Tyrolean Iceman, a 5,300-year-old Copper age individual, was discovered in 1991 on the Tisenjoch Pass in the Italian part of the Ötztal Alps. Here we report the complete genome sequence of the Iceman and show 100% concordance between the previously reported mitochondrial genome sequence and the consensus sequence generated from our genomic data. We present indications for recent common ancestry between the Iceman and presentday inhabitants of the Tyrrhenian sea, that the Iceman probably had brown eyes, belonged to blood group o and was lactose intolerant. His genetic predisposition shows an increased risk for coronary heart disease and may have contributed to the development of previously reported vascular calcifications. sequences corresponding to ~60% of the genome of Borrelia burgdorferi are indicative of the earliest human case of infection with the pathogen for Lyme borreliosis.

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“…Aqueous solutions of PCR components were screened for purity with a highly sensitive contamination monitoring protocol (intra Alu-PCR) reported elsewhere 39,40 .…”

Section: Methodsmentioning

confidence: 99%

New insights into the Tyrolean Iceman's origin and phenotype as inferred by whole-genome sequencing

et al. 2012

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“…Secondly, the adverse effects of consanguineous marriage on fitness traits such as survival and fertility cannot be easily investigated in those dynasties because information on such characters is hardly available from the ancient record. A way to circumvent some of the limitations in the study of inbreeding from ancient dynasties is exemplified in an analysis of microsatellite loci of a number of royal mummies of the 18th Egyptian dynasty (Hawass et al, 2010). The analysis of genetic relationships among individuals from those molecular markers allowed the identification of close relatives in such a way that a five-generation pedigree that included Akhenaton and Tutankhamun pharaohs was inferred.…”

Section: Introductionmentioning

confidence: 99%

Royal dynasties as human inbreeding laboratories: the Habsburgs

Ceballos

Álvarez

2013

Heredity

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The European royal dynasties of the Early Modern Age provide a useful framework for human inbreeding research. In this article, consanguineous marriage, inbreeding depression and the purging of deleterious alleles within a consanguineous population are investigated in the Habsburgs, a royal dynasty with a long history of consanguinity over generations. Genealogical information from a number of historical sources was used to compute kinship and inbreeding coefficients for the Habsburgs. The marriages contracted by the Habsburgs from 1450 to 1750 presented an extremely high mean kinship (0.0628±0.009), which was the result of the matrimonial policy conducted by the dynasty to establish political alliances through marriage. A strong inbreeding depression for both infant and child survival was detected in the progeny of 71 Habsburg marriages in the period 1450-1800. The inbreeding load for child survival experienced a pronounced decrease from 3.98±0.87 in the period 1450-1600 to 0.93±0.62 in the period 1600-1800, but temporal changes in the inbreeding depression for infant survival were not detected. Such a reduction of inbreeding depression for child survival in a relatively small number of generations could be caused by elimination of deleterious alleles of a large effect according with predictions from purging models. The differential purging of the infant and child inbreeding loads suggest that the genetic basis of inbreeding depression was probably very different for infant and child survival in the Habsburg lineage. Our findings provide empirical support that human inbreeding depression for some fitness components might be purged by selection within consanguineous populations.

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“…The first DNA sequences thought to be from a mummy 2 were probably the result of modern contamination, and many scientists are sceptical 3 of purported genetic information acquired from the mummy of King Tutankhamun 4 .…”

Section: By T R Ac I Wats O Nmentioning

confidence: 99%

UK election: science spending pledges overshadowed by Brexit

Cressey¹

2017

Nature

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Ancestry and Pathology in King Tutankhamun's Family

Cited by 245 publications

References 32 publications

New insights into the Tyrolean Iceman's origin and phenotype as inferred by whole-genome sequencing

New insights into the Tyrolean Iceman's origin and phenotype as inferred by whole-genome sequencing

Royal dynasties as human inbreeding laboratories: the Habsburgs

UK election: science spending pledges overshadowed by Brexit

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