Ancestral structure prediction reveals the conformational impact of the RuBisCO small subunit across time
Kaustubh Amritkar,
Bruno Cuevas,
Betul Kacar
Abstract:Ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) is an ancient protein critical for CO2-fixation and global biogeochemistry. Form-I RuBisCO complexes uniquely harbor small subunits that form a hexadecameric complex together with their large subunits. The small subunit protein is thought to have significantly contributed to RuBisCO s response to the atmospheric rise of O2 ~2.5 billion years ago, marking a pivotal point in the enzyme s evolutionary history. Here, we performed a comprehensive evolutionar… Show more
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