Ancestral lipid biosynthesis and early membrane evolution

Peretó, Juli; López‐García, Purificación; Moreira, David

doi:10.1016/j.tibs.2004.07.002

Cited by 248 publications

(241 citation statements)

References 36 publications

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Section: The Independent Transformation Of Three Lineages Of Rna Cellmentioning

confidence: 99%

“…Archaeal and bacterial (eukaryal) lipids have opposite chirality, because the formation of the covalent linkages between the glycerol and the acyl chains are formed by nonhomologous enzymes with different stereochemistry (34). These enzymes were recruited from two different dehydrogenase superfamilies that were likely both present in LUCA (34). Although the nature of the lipids present in LUCA cannot be inferred from comparative genomic analysis, it is reasonable to suggest that during the diversification of RNA cells from LUCA, some cellular lineages ended up by using specifically one of the two types of lipids.…”

Section: The Independent Transformation Of Three Lineages Of Rna Cellmentioning

confidence: 99%

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Three RNA cells for ribosomal lineages and three DNA viruses to replicate their genomes: A hypothesis for the origin of cellular domain

Forterre

2006

Proc. Natl. Acad. Sci. U.S.A.

213

174

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The division of the living world into three cellular domains, Archaea, Bacteria, and Eukarya, is now generally accepted. However, there is no consensus about the evolutionary relationships among these domains, because all of the proposed models have a number of more or less severe pitfalls. Another drawback of current models for the universal tree of life is the exclusion of viruses, otherwise a major component of the biosphere. Recently, it was suggested that the transition from RNA to DNA genomes occurred in the viral world, and that cellular DNA and its replication machineries originated via transfers from DNA viruses to RNA cells. Here, I explore the possibility that three such independent transfers were at the origin of Archaea, Bacteria, and Eukarya, respectively. The reduction of evolutionary rates following the transition from RNA to DNA genomes would have stabilized the three canonical versions of proteins involved in translation, whereas the existence of three different founder DNA viruses explains why each domain has its specific DNA replication apparatus. In that model, plasmids can be viewed as transitional forms between DNA viruses and cellular chromosomes, and the formation of different levels of cellular organization (prokaryote or eukaryote) could be traced back to the nature of the founder DNA viruses and RNA cells.

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Section: The Independent Transformation Of Three Lineages Of Rna Cellmentioning

confidence: 99%

Section: The Independent Transformation Of Three Lineages Of Rna Cellmentioning

confidence: 99%

Three RNA cells for ribosomal lineages and three DNA viruses to replicate their genomes: A hypothesis for the origin of cellular domain

Forterre

2006

Proc. Natl. Acad. Sci. U.S.A.

213

174

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“…The biosynthetic pathways to produce the two types of homochiral membranes would have evolved as archaea and bacteria diverged. This is supported by recent phylogenetic analyses of the enzymes involved suggesting that the cenancestor synthesized phospholipids via a non-stereospecific pathway (Pereto´et al, 2004). In addition, the occurrence of universally conserved membrane-bound proteins, such as the protonpump ATPases (Gogarten et al, 1989) and the signal recognition particle, SRP (Gribaldo and Cammarano 1998) fully supports the hypothesis of a cenancestor endowed with lipid membranes.…”

Section: The Membrane Of the Cenancestormentioning

confidence: 59%

5. Prebiotic Chemistry – Biochemistry – Emergence of Life (4.4–2 Ga)

et al. 2006

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Abstract. This chapter is devoted to a discussion about the difficulties and even the impossibility to date the events that occurred during the transition from non-living matter to the first living cells. Nevertheless, the attempts to devise plausible scenarios accounting for the emergence of the main molecular devices and processes found in biology are presented including the role of nucleotides at early stages (RNA world). On the other hand, hypotheses on the development of early metabolisms, comEarth, Moon, and Planets (2006) 98: 153-203 Ó Springer 2006

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“…The other important feature of living beings, explored by Eörs Szathmáry and present in Mirkin's reconstruction, was metabolism. The dispute over the nature of the genome of the last common ancestor and the nature of its membranes is still open in the scientific community (Peretó, López García, & Moreira, 2004;Poole et al, 2014).…”

Section: N New Genes Lost Genes and The Cenancestormentioning

confidence: 99%

The universal ancestor: An unfinished reconstruction

Becerra

Delaye

2015

Mètode

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The cenancestor is defined as the last common ancestor of every currently living being. Its nature has been inferred from the identification of homologous genes between archaea, bacteria, and eukaryotic lineages. These inferences indicate that the cenancestor had a relatively modern protein translation system, similar in complexity to that of a current cell. However, the key enzymes for the replication of genetic material and for cell membrane biosynthesis are not homologous in bacteria, archaea, and eukaryotes. Here, we briefly review the history of the concept of the last universal common ancestor and the different hypotheses proposed for its biology.

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Ancestral lipid biosynthesis and early membrane evolution

Cited by 248 publications

References 36 publications

Three RNA cells for ribosomal lineages and three DNA viruses to replicate their genomes: A hypothesis for the origin of cellular domain

Three RNA cells for ribosomal lineages and three DNA viruses to replicate their genomes: A hypothesis for the origin of cellular domain

5. Prebiotic Chemistry – Biochemistry – Emergence of Life (4.4–2 Ga)

The universal ancestor: An unfinished reconstruction

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