Ancestral genetic components are consistently associated with the complex trait landscape in European biobanks
Vasili Pankratov,
Massimo Mezzavilla,
Serena Aneli
et al.
Abstract:The genetic structure in Europe was mostly shaped by admixture between the Western Hunter-Gatherer, Anatolian Neolithic and Steppe’s Yamnaya ancestral components. Such structure is regarded as a confounder in GWAS and follow-up studies, and gold-standard methods exist to correct for it. However, it is still poorly understood to which extent these ancestral components contribute to complex trait variation in present-day Europe.In this work we harness the UK Biobank to address this question. By extensive demogra… Show more
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