ANCA‐positive periaortic vasculitis: does it fall within the spectrum of vasculitis?

Vaglio, Augusto; Manenti, Lucio; Allegri, Landino; Ferrozzi, F; Corradi, Domenico; Buzio, Carlo

doi:10.1046/j.1365-2796.2002.00948.x

Cited by 49 publications

(35 citation statements)

References 11 publications

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“…Likewise, in a recent study, we found that in 7 (44%) of 16 cases CP was associated with other autoimmune conditions, namely ANCA-positive renal disease and autoimmune tyroiditis (7). Finally, various case reports have described an association between CP and numerous autoimmune diseases including well-defined small-and medium-vessel vasculitis (Wegener's granulomatosis, polyarteritis nodosa, Henoch-Schoenlein purpura) (9 -11), unclassifiable "systemic vasculitis" (8,12), aortitis (13), or different types of immune-mediated glomerulonephritis (membranous, membrano-proliferative, and rapidly progressive glomerulonephritis) (18,19). Ankylosing spondylitis, a condition sometimes linked to ascending aortitis, has also been reported to be associated with CP (12,20,21), whereas the association with rheumatoid arthritis and systemic lupus erythematosus is uncommon (7,22).…”

Section: Discussionmentioning

confidence: 99%

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Positron emission tomography (PET): Evaluation of chronic periaortitis

Salvarani¹,

Pipitone²,

Versari³

et al. 2005

Arthritis & Rheumatism

131

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Objective. To evaluate the presence and extent of large-vessel inflammation in patients with chronic periaortitis (CP) using 18 F-fluorodeoxyglucose-positron emission tomography (FDG-PET). Methods. A consecutive case series consisting of 7 patients with CP seen over a 3-year period and a control group of 14 patients with malignancy were evaluated with FDG-PET. For every case we selected 2 age-and sex-matched controls who underwent PET imaging for malignancy. The diagnosis of CP was made by means of computed tomography. PET imaging was performed at diagnosis before therapy was started. Measurement of vascular uptake was graded using a 4-point semiquantitative scale. Results. All patients had evidence of grade 2؉ or 3؉ vascular uptake in the abdominal aorta and/or iliac artery. No controls showed vascular uptake greater than 1؉. Vascular uptake in the thoracic aorta and/or in its branches was seen in 3 (43%) of 7 patients. Vascular uptake in abdominal aorta and/or iliac artery was observed in patients with CP but not in controls (100% versus 0%). There was also a significantly more frequent FDG uptake in the large thoracic arteries in case-patients compared with controls (43% versus 0%; P ‫؍‬ 0.03). Conclusion. FDG-PET scan shows in patients with CP the presence of a large-vessel vasculitis involving abdominal aorta and common iliac arteries, which in some patients is also extended to thoracic aorta and/or its branches.

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Section: Discussionmentioning

confidence: 99%

“…Recently, 18 F-fluorodeoxyglucose-positron emission tomography (FDG-PET) has been proposed as a potentially useful tool for detection of inflammatory changes in largevessel vasculitis (14,15). FDG is a deoxyglucose labeled with fluorine-18 ( 18 F), a positron-emitting radionuclide that identifies areas of high glucose metabolic activity.…”

Section: Introductionmentioning

confidence: 99%

Positron emission tomography (PET): Evaluation of chronic periaortitis

Salvarani¹,

Pipitone²,

Versari³

et al. 2005

Arthritis & Rheumatism

131

View full text Add to dashboard Cite

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“…In most cases it is idiopathic, but it may also be secondary to infections, malignancies, or drugs or it may be associated with systemic autoimmune diseases (2,3).…”

Section: Introductionmentioning

confidence: 99%

¹⁸F‐fluorodeoxyglucose positron emission tomography in the diagnosis and followup of idiopathic retroperitoneal fibrosis

Vaglio¹,

Versari²,

Fraternali³

et al. 2005

Arthritis & Rheumatism

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“…An extensive review of the literature revealed eight cases including the present case with PR3-ANCA positive retroperitoneal fibrosis (27)(28)(29)(30)(31)(32)(33). Two cases showed signs of Wegener's granulomatosis, and one had Riedel's disease, an IgG4-related disease.…”

Section: Discussionmentioning

confidence: 70%

Proteinase 3 Anti-Neutrophil Cytoplasmic Antibody (PR3-ANCA) Positive IgG4-Related Retroperitoneal Fibrosis: Utility of PET-CT with <sup>18</sup>F-Fluorodeoxy Glucose (FDG)

et al. 2012

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A 55-year-old man showed a serum creatinine level of 1.51 mg/dL, CRP of 0.79 mg/dL, and proteinase 3 anti-neutrophil cytoplasmic antibody (PR3-ANCA) of 43.9 EU (normal range: below 10). The serum levels and ratios of IgG1, IgG2, IgG3, and IgG4 to total IgG were 1,570 mg/dL (49%), 1,190 mg/dL (37%), 82 mg/dL (3%), and 351 mg/dL (11%), respectively. Positron emission tomography and CT with 18 Ffluorodeoxyglucose (PET-CT) demonstrated retroperitoneal fibrosis. After a diagnosis of IgG4-related retroperitoneal fibrosis with PR3-ANCA was made, oral prednisolone improved serum creatinine and the titer of PR3-ANCA to normal levels, with no abnormal findings on PET-CT.

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ANCA‐positive periaortic vasculitis: does it fall within the spectrum of vasculitis?

Cited by 49 publications

References 11 publications

Positron emission tomography (PET): Evaluation of chronic periaortitis

Positron emission tomography (PET): Evaluation of chronic periaortitis

¹⁸F‐fluorodeoxyglucose positron emission tomography in the diagnosis and followup of idiopathic retroperitoneal fibrosis

Proteinase 3 Anti-Neutrophil Cytoplasmic Antibody (PR3-ANCA) Positive IgG4-Related Retroperitoneal Fibrosis: Utility of PET-CT with <sup>18</sup>F-Fluorodeoxy Glucose (FDG)

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ANCA‐positive periaortic vasculitis: does it fall within the spectrum of vasculitis?

Cited by 49 publications

References 11 publications

Positron emission tomography (PET): Evaluation of chronic periaortitis

Positron emission tomography (PET): Evaluation of chronic periaortitis

18F‐fluorodeoxyglucose positron emission tomography in the diagnosis and followup of idiopathic retroperitoneal fibrosis

Proteinase 3 Anti-Neutrophil Cytoplasmic Antibody (PR3-ANCA) Positive IgG4-Related Retroperitoneal Fibrosis: Utility of PET-CT with <sup>18</sup>F-Fluorodeoxy Glucose (FDG)

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¹⁸F‐fluorodeoxyglucose positron emission tomography in the diagnosis and followup of idiopathic retroperitoneal fibrosis