ANCA-positive and ANCA-negative phenotypes of eosinophilic granulamatosis and polyangiitis (EGPA): Outcome and long-term follow-up of 46 patients from a single Polish centre

Szczeklik, Wojciech; Sokołowska, Barbara; Kuczia, Pawel; Gąsior, Jolanta; Maga, Mikołaj; Bartyzel, S.; Musiał, Jacek

doi:10.1016/j.lpm.2013.02.112

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Поражения внутренних органов при ЭГПА могут наблюдаться на стадиях эозинофильной инфильтрации и васкулита, при этом отмечается связь между выявлением АНЦА в крови и клинической картиной: поражение легких и миокарда более характерно для стадии эозинофильных инфильтратов, а вовлечение почек, кожных покровов, периферической нервной системы (ПНС) -для стадии васкулита [30,31]. АНЦА выявляются на стадии как эозинофильной инфильтрации (30-35% пациентов), так и васкулита (~70%).…”

Section: клинические проявленияunclassified

Neurological disorders in eosinophilic granulomatosis with polyangiitis (Churg—Strauss syndrome)

Gilyarov

Belikova

et al. 2016

Z. nevrol. psikhiatr. im. S.S. Korsakova

View full text Add to dashboard Cite

Eosinophilic granulomatosis with polyangiitis - EGPA (Churg-Strauss syndrome) is a rare autoimmune disorder. The pathogenesis of the disease includes production of anti-neutrophil cytoplasmic antibodies directed against myeloperoxidase with the development of small-vessel necrotizing vasculitis and eosinophilic infiltration of organs. The involvement of peripheral and central nervous system is observed in more than 3/4 of cases. The authors describe three patients with EGPA. In a 53-year-old male patient, EGPA manifested with multiple neuropathies, which regressed after treatment with corticosteroids and cytostatics. In a 34-year-old woman, cerebral sinus thrombosis and cerebral infarction developed in the non-active period of long-term EGPA. The patient was treated with anticoagulants. A 77-year-old woman with a newly diagnosed EGPA, confirmed by bone marrow examination for eosinophilia, developed ischemic stroke and polyneuropathy. The causes and mechanisms of development as well as dynamics and outcomes of neurological disorders, differential diagnosis, treatment and prognosis of eosinophilic granulomatosis with polyangiitis are discussed.

show abstract

Section: клинические проявленияunclassified

Neurological disorders in eosinophilic granulomatosis with polyangiitis (Churg—Strauss syndrome)

Gilyarov

Belikova

et al. 2016

Z. nevrol. psikhiatr. im. S.S. Korsakova

View full text Add to dashboard Cite

show abstract

“…Regarding the prostate biopsy, there was no neutrophilic infiltration, granulomatous formation, necrotizing vasculitis, or multinucleated giant cells. ANCA testing was negative; however, it should be noted that many patients with ANCA-associated vasculitides actually do not test positive for P-ANCA and C-ANCA 6. Although IgG4-RD and ANCA-associated vasculitides can overlap in clinical presentations, we further believe it is unlikely that the patient had an ANCA-associated vasculitis such as EGPA because dupilumab can actually raise eosinophil levels due to changes in VCAM-1 expression and eosinophilia is central to the pathophysiology of EGPA 7.…”

mentioning

confidence: 97%

Response to : ‘Interleukin-4 as a emerging target for IgG4-related disease’ by Akiyama et al

Simpson¹,

Lee²

2020

Ann Rheum Dis

View full text Add to dashboard Cite

ANCA-positive and ANCA-negative phenotypes of eosinophilic granulamatosis and polyangiitis (EGPA): Outcome and long-term follow-up of 46 patients from a single Polish centre

Cited by 2 publications

References 0 publications

Neurological disorders in eosinophilic granulomatosis with polyangiitis (Churg—Strauss syndrome)

Neurological disorders in eosinophilic granulomatosis with polyangiitis (Churg—Strauss syndrome)

Response to : ‘Interleukin-4 as a emerging target for IgG4-related disease’ by Akiyama et al

Contact Info

Product

Resources

About